Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor.

PubWeight™: 3.35‹?› | Rank: Top 1%

🔗 View Article (PMC 258872)

Published in Infect Immun on August 01, 1990

Authors

I E Flesch1, S H Kaufmann

Author Affiliations

1: Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.

Articles citing this

Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med (1993) 17.01

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med (1995) 3.86

CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect Immun (1995) 3.45

Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity (2008) 3.24

Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol (2008) 3.19

Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe (2007) 3.09

Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice. Infect Immun (1992) 2.50

Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am J Pathol (2004) 2.27

Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells. Eur J Immunol (2010) 2.25

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. J Infect Dis (2008) 2.05

Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection. J Exp Med (2001) 1.74

Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages. Infect Immun (1997) 1.73

Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection. J Immunol (2009) 1.66

Interleukin-12 in infectious diseases. Clin Microbiol Rev (1997) 1.63

HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria. Am J Respir Crit Care Med (2009) 1.54

Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells. Clin Exp Immunol (1993) 1.43

Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages. Infect Immun (1999) 1.43

Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis. Infect Immun (1994) 1.40

Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection. Infect Immun (2007) 1.40

Heterogeneity of the repertoire of T cells of tuberculosis patients and healthy contacts to Mycobacterium tuberculosis antigens separated by high-resolution techniques. Infect Immun (1992) 1.34

Immunological control of tuberculosis: role of tumour necrosis factor and more. Ann Rheum Dis (2005) 1.31

The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response. Infect Immun (2006) 1.30

Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect Immun (2000) 1.29

Granuloma formation in severe combined immunodeficient (SCID) mice in response to progressive BCG infection. Tendency not to form granulomas in the lung is associated with faster bacterial growth in this organ. Am J Pathol (1993) 1.24

CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infect Immun (1999) 1.23

A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Eur J Immunol (2010) 1.22

Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect Immun (1996) 1.20

Recombinant guinea pig tumor necrosis factor alpha stimulates the expression of interleukin-12 and the inhibition of Mycobacterium tuberculosis growth in macrophages. Infect Immun (2005) 1.17

In vitro characterization of T cells from Mycobacterium w-vaccinated mice. Infect Immun (1992) 1.16

Inhibition of ex vivo proinflammatory cytokine secretion in fatal Mycobacterium tuberculosis infection. Clin Exp Immunol (1995) 1.16

Fish monocytes as a model for mycobacterial host-pathogen interactions. Infect Immun (2001) 1.11

Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep (2013) 1.10

Pneumocystis carinii induces an oxidative burst in alveolar macrophages. Infect Immun (1992) 1.09

Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation. Infect Immun (2006) 1.07

Diagnostic implications of antigen-induced gamma interferon, nitric oxide, and tumor necrosis factor alpha production by peripheral blood mononuclear cells from Mycobacterium bovis-infected cattle. Clin Diagn Lab Immunol (2003) 1.04

Opsonizing antibodies (IgG1) up-regulate monocyte proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-6 but not anti-inflammatory cytokine IL-10 in mycobacterial antigen-stimulated monocytes-implications for pathogenesis. Clin Exp Immunol (2001) 1.02

A tumor necrosis factor mimetic peptide activates a murine macrophage cell line to inhibit mycobacterial growth in a nitric oxide-dependent fashion. Infect Immun (1998) 1.02

Roles for tumor necrosis factor alpha and nitric oxide in resistance of rat alveolar macrophages to Legionella pneumophila. Infect Immun (1996) 1.00

Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination. Infect Immun (2009) 1.00

Early clearance of Mycobacterium tuberculosis: a new frontier in prevention. Immunology (2014) 0.98

Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence. Microbes Infect (2010) 0.96

Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection. Infect Immun (2014) 0.96

Immunohistochemical analysis of cytokines and apoptosis in tuberculous lymphadenitis. Immunology (2006) 0.95

Macrophage response to Mycobacterium tuberculosis infection. J Math Biol (2003) 0.95

Effect of lipoarabinomannan and mycobacteria on tumour necrosis factor production by different populations of murine macrophages. Clin Exp Immunol (1993) 0.94

Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. Clin Exp Immunol (2007) 0.93

Comparison of gamma interferon, tumor necrosis factor, and direct cell contact in activation of antimycobacterial defense in murine macrophages. Infect Immun (1993) 0.92

Effect of Mycobacterium bovis BCG vaccination on Mycobacterium-specific cellular proliferation and tumor necrosis factor alpha production from distinct guinea pig leukocyte populations. Infect Immun (2003) 0.92

Differential cytokine gene expression and secretion after phagocytosis by a human monocytic cell line of Toxoplasma gondii compared with Mycobacterium tuberculosis. Clin Exp Immunol (1993) 0.91

Dual role of interleukin-4 (IL-4) in pulmonary paracoccidioidomycosis: endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern. Infect Immun (2004) 0.90

Activation of human Vgamma9Vdelta2 T cells by a Brucella suis non-peptidic fraction impairs bacterial intracellular multiplication in monocytic infected cells. Immunology (2000) 0.89

Follow-up results of 702 patients receiving tumor necrosis factor-α antagonists and evaluation of risk of tuberculosis. Rheumatol Int (2009) 0.89

Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo. Infect Immun (1999) 0.88

Intracerebral Mycobacterium bovis bacilli Calmette-Guerin infection-induced immune responses in the CNS. J Neuroimmunol (2009) 0.85

Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Arch (2008) 0.85

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression. BMC Microbiol (2006) 0.85

Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis. J Clin Invest (2014) 0.84

Differential effects of Radix Paeoniae Rubra (Chishao) on cytokine and chemokine expression inducible by mycobacteria. Chin Med (2011) 0.84

Assessment of in vitro immunity to Mycobacterium tuberculosis in a human peripheral blood infection model using a luciferase reporter construct of M. tuberculosis H37Rv. Clin Exp Immunol (2006) 0.83

Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy. J Immunol (2012) 0.83

In vitro T-cell activation of monocyte-derived macrophages by soluble messengers or cell-to-cell contact in bovine tuberculosis. Immunology (2000) 0.82

Lung macrophages from bacille Calmette-Guérin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth of M. tuberculosis after recombinant guinea pig interferon-gamma activation. Clin Exp Immunol (2007) 0.82

Cellular interactions in bovine tuberculosis: release of active mycobacteria from infected macrophages by antigen-stimulated T cells. Immunology (2000) 0.81

Interleukin-4 inhibits secretion of interleukin-1beta in the response of human cells to mycobacterial heat shock proteins. Clin Diagn Lab Immunol (1997) 0.81

Striking the right balance; the role of cytokines in mycobacterial disease. Clin Exp Immunol (1993) 0.80

Identification of a predominant isolate of Mycobacterium tuberculosis using molecular and clinical epidemiology tools and in vitro cytokine responses. BMC Infect Dis (2003) 0.80

Inhibition of Mycobacterium bovis BCG-induced tumor necrosis factor alpha secretion in human cells by transforming growth factor beta. Clin Diagn Lab Immunol (1998) 0.78

TNF-alpha antagonist therapy modify the tuberculin skin test response. Rheumatol Int (2010) 0.77

A role for interleukin-17A in modulating intracellular survival of Mycobacterium bovis bacillus Calmette-Guérin in murine macrophages. Immunology (2013) 0.77

Ecto-5'-Nucleotidase (CD73) Deficiency in Mycobacterium tuberculosis-Infected Mice Enhances Neutrophil Recruitment. Infect Immun (2015) 0.76

Bayesian approach to model CD137 signaling in human M. tuberculosis in vitro responses. PLoS One (2013) 0.75

Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation. Sci Rep (2016) 0.75

SP110b Controls Host Immunity and Susceptibility to Tuberculosis. Am J Respir Crit Care Med (2016) 0.75

The Wnt Blows: On the Functional Role of Wnt Signaling in Mycobacterium tuberculosis Infection and Beyond. Front Immunol (2016) 0.75

Cytokine signature and antibody-mediated response against fresh and attenuated Anisakis simplex (L3) administration into Wistar rats: implication for anti-allergic reaction. Parasitol Res (2015) 0.75

Articles cited by this

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08

Activation of mononuclear phagocytes: fact, fancy, and future. J Immunol (1978) 6.22

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun (1985) 4.56

Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J Immunol (1987) 3.68

B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol (1987) 3.18

Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. J Exp Med (1988) 2.89

Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection. J Immunol (1988) 2.82

Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun (1987) 2.42

Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages. J Immunol (1987) 1.62

Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6). Infect Immun (1990) 1.57

Growth requirements of murine bone marrow macrophages in serum-free cell culture. Immunobiology (1986) 1.19

Articles by these authors

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (1994) 10.22

The role of cell-mediated immunity in bacterial infections. Rev Infect Dis (1982) 9.26

Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem (1999) 8.16

Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science (1989) 4.19

CD8+ T lymphocytes in intracellular microbial infections. Immunol Today (1988) 4.12

Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon. Eur J Immunol (1984) 4.00

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. J Exp Med (1986) 3.92

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. Infect Immun (1987) 3.87

Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J Immunol (1987) 3.68

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest (2000) 3.58

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. Infect Immun (1991) 3.54

Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo. J Exp Med (1982) 3.52

Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. Nature (1993) 3.47

Mycobacterial protein antigens: a compilation. Mol Microbiol (1992) 3.35

Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens. J Exp Med (1979) 3.31

Immune response to infection with Salmonella typhimurium in mice. J Leukoc Biol (2000) 2.99

Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J Immunol (1996) 2.97

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A (1995) 2.89

Mycobacteria-reactive Lyt-2+ T cell lines. Eur J Immunol (1988) 2.88

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J Exp Med (1995) 2.80

T cells against a bacterial heat shock protein recognize stressed macrophages. Science (1989) 2.79

Assessment of aldehyde dehydrogenase in viable cells. Blood (1995) 2.77

Effective protection against Listeria monocytogenes and delayed-type hypersensitivity to listerial antigens depend on cooperation between specific L3T4+ and Lyt 2+ T cells. Infect Immun (1985) 2.70

Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev (1999) 2.69

T- and B-lymphocyte-independent formation of alveolar macrophage-derived multinucleated giant cells in murine Pneumocystis carinii pneumonia. Infect Immun (1996) 2.55

Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance. Eur J Immunol (1995) 2.48

The role of T-cell subsets and cytokines in the regulation of infection. Immunol Today (1991) 2.48

Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect Immun (1994) 2.45

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur J Immunol (1987) 2.45

Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells. J Exp Med (1986) 2.42

Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection. J Immunol (1994) 2.39

A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein. J Exp Med (1990) 2.37

Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors. Eur J Immunol (1998) 2.35

The role of proteases during apoptosis. FASEB J (1996) 2.35

Protective role of gamma/delta T cells and alpha/beta T cells in tuberculosis. Eur J Immunol (1995) 2.34

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest (1999) 2.32

Lethal tuberculosis in interleukin-6-deficient mutant mice. Infect Immun (1997) 2.31

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31

Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens. Mol Microbiol (1999) 2.28

Primary responses of human T cells to mycobacteria: a frequent set of gamma/delta T cells are stimulated by protease-resistant ligands. Eur J Immunol (1990) 2.25

Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes. Nat Biotechnol (1998) 2.25

Caspases and caspase inhibitors. Trends Biochem Sci (1997) 2.17

Interferon-gamma production by Listeria monocytogenes-specific T cells active in cellular antibacterial immunity. Eur J Immunol (1983) 2.06

Antigen-specific Lyt-2+ cytolytic T lymphocytes from mice infected with the intracellular bacterium Listeria monocytogenes. J Immunol (1986) 2.04

Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (1977) 2.01

Considerations in the isolation of rat liver nuclear matrix, nuclear envelope, and pore complex lamina. Exp Cell Res (1981) 1.99

Fungicidal activity of IFN-gamma-activated macrophages. Extracellular killing of Cryptococcus neoformans. J Immunol (1989) 1.97

Acquired resistance to facultative intracellular bacteria: relationship between persistence, cross-reactivity at the T-cell level, and capacity to stimulate cellular immunity of different Listeria strains. Infect Immun (1984) 1.96

Absolute lymphocyte count recovery after induction chemotherapy predicts superior survival in acute myelogenous leukemia. Leukemia (2006) 1.95

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein. J Immunol (1989) 1.94

The current status of camptothecin analogues as antitumor agents. J Natl Cancer Inst (1993) 1.84

Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages. Infect Immun (1988) 1.80

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood (2001) 1.78

Characterization of the major polypeptides of the rat liver nuclear envelope. J Biol Chem (1983) 1.75

Immune responses to intracellular bacteria. Curr Opin Immunol (2001) 1.75

Target cell lysis and IL-2 secretion by gamma/delta T lymphocytes after activation with bacteria. J Immunol (1990) 1.71

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood (1996) 1.70

Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium tuberculosis. J Infect Dis (2000) 1.68

Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10. Int Immunol (1994) 1.68

Effective antibacterial protection induced by a Listeria monocytogenes-specific T cell clone and its lymphokines. Infect Immun (1983) 1.68

Iron overload in beta 2-microglobulin-deficient mice. Immunol Lett (1994) 1.67

Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection. Infect Immun (2000) 1.67

Immunity against intracellular bacteria: biological effector functions and antigen specificity of T lymphocytes. Curr Top Microbiol Immunol (1988) 1.65

Mycobacterium bovis Bacille Calmette-Guérin strains secreting listeriolysin of Listeria monocytogenes. Proc Natl Acad Sci U S A (1998) 1.63

Specific lysis of Listeria monocytogenes-infected macrophages by class II-restricted L3T4+ T cells. Eur J Immunol (1987) 1.62

Function and antigen recognition pattern of L3T4+ T-cell clones from Mycobacterium tuberculosis-immune mice. Infect Immun (1986) 1.61

Confrontation between intracellular bacteria and the immune system. Adv Immunol (1999) 1.61

Severe graft-versus-host disease in a liver-transplant recipient. N Engl J Med (1988) 1.59

Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb (1992) 1.59

Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6). Infect Immun (1990) 1.57

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms. Cancer Res (1996) 1.56

Contribution of alpha/beta and gamma/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guérin: studies with T cell receptor-deficient mutant mice. Eur J Immunol (1995) 1.55

CD1 and CD1-restricted T cells in infections with intracellular bacteria. Trends Microbiol (2000) 1.55

Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection. J Immunol (2000) 1.54

Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis. Proc Natl Acad Sci U S A (1996) 1.52

JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia (2006) 1.51

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. Chromosoma (2001) 1.50

Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage. J Biol Chem (2000) 1.50

From evil to good: a cytolysin in vaccine development. Trends Microbiol (2001) 1.50

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res (1996) 1.50

Interleukin 2 induction in Lyt 1+ 23- T cells from Listeria monocytogenes-immune mice. Infect Immun (1982) 1.49

Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan. Infect Immun (1997) 1.47

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor. J Clin Oncol (1992) 1.46

Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem (1997) 1.46

T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis. Eur J Immunol (1988) 1.46

The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. Cancer Res (2001) 1.45

Role of cytokines in tuberculosis. Immunobiology (1993) 1.44

Regulatory interactions between macrophages and T-cell subsets in Listeria monocytogenes-specific T-cell activation. Infect Immun (1982) 1.43

A phase II "window" study of topotecan in untreated patients with high risk adult acute lymphoblastic leukemia. Clin Cancer Res (1998) 1.42

The erasable Western blot. Anal Biochem (1987) 1.41

Pneumocystis carinii and the immune response in disease. Trends Microbiol (1998) 1.41

Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes. Infect Immun (1993) 1.40

Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy. Leuk Res (2002) 1.38

Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent. Proc Natl Acad Sci U S A (1993) 1.38

Heterogeneity of the repertoire of T cells of tuberculosis patients and healthy contacts to Mycobacterium tuberculosis antigens separated by high-resolution techniques. Infect Immun (1992) 1.34

Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics. Infect Immun (2001) 1.34

Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration. Cancer Res (1997) 1.33

Comparison of potential markers of farnesyltransferase inhibition. Clin Cancer Res (2000) 1.32

The many faces of host responses to tuberculosis. Immunology (2001) 1.30