Published in PLoS Negl Trop Dis on December 07, 2010
Identification of new antileishmanial leads from hits obtained by high-throughput screening. Antimicrob Agents Chemother (2011) 1.00
Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model. Lipids Health Dis (2011) 0.81
Investigational drugs for visceral leishmaniasis. Expert Opin Investig Drugs (2014) 0.79
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Efficacy of an oral and tropically stable lipid-based formulation of Amphotericin B (iCo-010) in an experimental mouse model of systemic candidiasis. Lipids Health Dis (2013) 0.75
Synergistic enhancement of parasiticidal activity of amphotericin B using copaiba oil in nanoemulsified carrier for oral delivery: an approach for non-toxic chemotherapy. Br J Pharmacol (2015) 0.75
In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines. Lipids Health Dis (2011) 0.75
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Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. J Infect Dis (2009) 1.13
Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. Int J Pharm (2009) 1.10
Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation. J Antimicrob Chemother (2009) 1.07
Pathophysiology of visceral leishmaniasis - some recent concepts. Indian J Med Res (2006) 0.89
Kupffer cells do not play a role in governing the efficacy of liposomal mitoxantrone used to treat a tumor model designed to assess drug delivery to liver. Clin Cancer Res (2000) 0.81
Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet (2005) 5.09
Generalized T2 test for genome association studies. Am J Hum Genet (2002) 4.55
Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet (2010) 3.03
Collagen turnover in the adult femoral mid-shaft: modeled from anthropogenic radiocarbon tracer measurements. Am J Phys Anthropol (2007) 2.28
The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J (2010) 2.04
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (2005) 1.94
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrob Agents Chemother (2009) 1.73
Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci (2003) 1.67
Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate (2010) 1.59
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrob Agents Chemother (2006) 1.57
Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases. Pharm Res (2008) 1.54
Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res (2004) 1.47
Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrob Agents Chemother (2010) 1.45
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob Agents Chemother (2007) 1.44
A large case-control study reveals a positive association between bisphosphonate use and delayed dental healing and osteonecrosis of the jaw. J Bone Miner Res (2014) 1.42
Diamidines for human African trypanosomiasis. Curr Opin Investig Drugs (2010) 1.42
Is bisphosphonate therapy for benign bone disease associated with impaired dental healing? A case-controlled study. BMC Musculoskelet Disord (2011) 1.37
Which new approaches to tackling neglected tropical diseases show promise? PLoS Med (2010) 1.34
CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metab Dispos (2006) 1.30
Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Mol Pharmacol (2006) 1.25
The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world. J Pharm Sci (2009) 1.23
The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. Antimicrob Agents Chemother (2007) 1.22
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat Rev Drug Discov (2008) 1.17
Structure-activity study of pentamidine analogues as antiprotozoal agents. J Med Chem (2009) 1.16
Femoral neck trabecular bone: loss with aging and role in preventing fracture. J Bone Miner Res (2009) 1.16
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metab Dispos (2007) 1.14
Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. J Infect Dis (2009) 1.13
Cyclosporine A: a review of current oral and intravenous delivery systems. Drug Dev Ind Pharm (2007) 1.11
Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. Int J Pharm (2009) 1.10
Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging. Sci Rep (2013) 1.10
Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Acta Trop (2004) 1.08
Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase. Drug Metab Dispos (2005) 1.08
High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 1.07
Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation. J Antimicrob Chemother (2009) 1.07
DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob Agents Chemother (2004) 1.05
Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry. J Mass Spectrom (2004) 1.05
Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. PLoS Negl Trop Dis (2012) 1.04
Antileishmanial activities of several classes of aromatic dications. Antimicrob Agents Chemother (2002) 1.02
Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies. J Pharm Sci (2007) 1.02
A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol Sci (2012) 1.02
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorg Med Chem Lett (2005) 1.02
Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake. Adv Drug Deliv Rev (2004) 1.02
The pharmacokinetics of amprenavir, zidovudine, and lamivudine in the genital tracts of men infected with human immunodeficiency virus type 1 (AIDS clinical trials group study 850). J Infect Dis (2002) 1.01
Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences. J Anat (2005) 1.01
Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Bioorg Med Chem (2008) 1.01
Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metab Dispos (2008) 1.01
Designed compounds for recognition of 10 base pairs of DNA with two at binding sites. J Am Chem Soc (2012) 1.00
Identification of new antileishmanial leads from hits obtained by high-throughput screening. Antimicrob Agents Chemother (2011) 1.00
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. J Med Chem (2010) 1.00
Effects of lipid-based oral formulations on plasma and tissue amphotericin B concentrations and renal toxicity in male rats. Antimicrob Agents Chemother (2003) 1.00
A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine. J Am Chem Soc (2006) 1.00
Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis (2008) 0.99
Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment. J Psychiatry Neurosci (2007) 0.99
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles. J Med Chem (2007) 0.98
Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. Pharm Res (2002) 0.98
Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis. J Parasitol (2008) 0.98
MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1. J Dermatol Sci (2012) 0.96
The diamidine DB75 targets the nucleus of Plasmodium falciparum. Malar J (2009) 0.96
Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft. Bone (2007) 0.96
Knockdown of scavenger receptor class B type I reduces prostate specific antigen secretion and viability of prostate cancer cells. Prostate (2011) 0.95
Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone. J Anat (2006) 0.95
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs. Pharm Res (2005) 0.94
Postnatal manipulation of Pax6 dosage reverses congenital tissue malformation defects. J Clin Invest (2013) 0.94
The relation of femoral osteon geometry to age, sex, height and weight. Bone (2009) 0.94
Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers. Antimicrob Agents Chemother (2004) 0.93
The inhibition of collagenase induced degradation of collagen by the galloyl-containing polyphenols tannic acid, epigallocatechin gallate and epicatechin gallate. J Mater Sci Mater Med (2010) 0.93
Major depression and coronary flow reserve detected by positron emission tomography. Arch Intern Med (2009) 0.93
Serotonin transporter gene, depressive symptoms, and interleukin-6. Circ Cardiovasc Genet (2009) 0.93
The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model. Eur J Pharm Biopharm (2007) 0.92
Preferred collagen fiber orientation in the human mid-shaft femur. Anat Rec A Discov Mol Cell Evol Biol (2003) 0.92
Variation in osteocyte lacunar morphology and density in the human femur--a synchrotron radiation micro-CT study. Bone (2012) 0.92
Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint. J Pharm Sci (2004) 0.91
The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis. Expert Opin Drug Deliv (2009) 0.91
Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice. Metabolism (2003) 0.91
Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance. Prostate (2010) 0.91
A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities. Mol Cancer Ther (2006) 0.91
Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany NY) (2014) 0.91
Cholesterol as a potential target for castration-resistant prostate cancer. Pharm Res (2010) 0.90
Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.90
QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study. Aging (Albany NY) (2013) 0.89
In vitro human plasma distribution of nanoparticulate paclitaxel is dependent on the physicochemical properties of poly(ethylene glycol)-block-poly(caprolactone) nanoparticles. Eur J Pharm Biopharm (2008) 0.89
Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma. Lipids Health Dis (2009) 0.89
Network-based regulatory pathways analysis. Bioinformatics (2004) 0.89
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. J Med Chem (2008) 0.89
Three-dimensional microcomputed tomography imaging of basic multicellular unit-related resorption spaces in human cortical bone. Anat Rec A Discov Mol Cell Evol Biol (2006) 0.89
Femoral osteocyte lacunar density, volume and morphology in women across the lifespan. J Struct Biol (2013) 0.88
Detecting hemifacial asymmetries in emotional expression with three-dimensional computerized image analysis. Proc Biol Sci (2004) 0.88
Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT). Prostate (2008) 0.88
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. J Med Chem (2013) 0.88
Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models. J Pharmacol Exp Ther (2011) 0.88
Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes. Biomaterials (2009) 0.87