Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 3029903)

Published in J Am Soc Nephrol on December 16, 2010

Authors

Katharina Hochheiser1, Daniel R Engel, Linda Hammerich, Felix Heymann, Percy A Knolle, Ulf Panzer, Christian Kurts

Author Affiliations

1: Institute of Experimental Immunology (IMMEI), Friedrich-Wilhelms-Universität, 53105 Bonn, Germany. ckurts@web.de

Articles citing this

Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol (2011) 3.68

The renal mononuclear phagocytic system. J Am Soc Nephrol (2011) 1.84

The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol (2013) 1.76

Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. J Am Soc Nephrol (2013) 1.54

Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis. Front Endocrinol (Lausanne) (2013) 1.34

Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol (2011) 1.02

IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN. J Am Soc Nephrol (2012) 0.99

Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression. J Clin Invest (2013) 0.98

Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN. J Am Soc Nephrol (2012) 0.95

Epithelial cell TGFβ signaling induces acute tubular injury and interstitial inflammation. J Am Soc Nephrol (2013) 0.94

Dendritic cells and macrophages in the kidney: a spectrum of good and evil. Nat Rev Nephrol (2014) 0.86

The loss of renal dendritic cells and activation of host adaptive immunity are long-term effects of ischemia/reperfusion injury following syngeneic kidney transplantation. Kidney Int (2012) 0.83

Update on crescentic glomerulonephritis. Semin Immunopathol (2014) 0.82

Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN. J Am Soc Nephrol (2014) 0.82

IL-6 Trans-Signaling Drives Murine Crescentic GN. J Am Soc Nephrol (2015) 0.82

Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity. Am J Physiol Renal Physiol (2013) 0.81

Innate and adaptive immunity in experimental glomerulonephritis: a pathfinder tale. Pediatr Nephrol (2016) 0.79

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy. J Am Soc Nephrol (2016) 0.77

CD103+ Dendritic Cells Elicit CD8+ T Cell Responses to Accelerate Kidney Injury in Adriamycin Nephropathy. J Am Soc Nephrol (2015) 0.76

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells. J Am Soc Nephrol (2016) 0.75

Articles cited by this

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

A theory of self-nonself discrimination. Science (1970) 7.99

Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol (2006) 6.62

Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med (1997) 5.72

Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46

Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol (2007) 5.31

Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science (2008) 3.97

CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int (2006) 3.53

How does proteinuria cause progressive renal damage? J Am Soc Nephrol (2006) 3.46

Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol (1999) 3.10

Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int (2007) 2.98

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J Exp Med (1994) 2.71

Compartment specific expression of dendritic cell markers in human glomerulonephritis. Kidney Int (2008) 2.21

Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol (2004) 2.18

The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 2.06

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest (2009) 2.01

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol (2004) 1.94

Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides. J Am Soc Nephrol (2008) 1.89

IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J Am Soc Nephrol (2009) 1.62

Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions. Kidney Int (2007) 1.52

T cells in crescentic glomerulonephritis. J Am Soc Nephrol (2006) 1.45

Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol (2009) 1.39

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol (2008) 1.38

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol (2009) 1.29

Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction. Kidney Int (2008) 1.27

Characterization and distribution of interstitial cell types in the renal cortex of rats. Kidney Int (1994) 1.22

IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. J Am Soc Nephrol (2005) 1.20

Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. J Am Soc Nephrol (2003) 1.19

The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol (2008) 1.12

Anti-GBM nephritis in the mouse: severe proteinuria in the heterologous phase. Virchows Arch A Pathol Anat Histopathol (1985) 1.09

Role of T cells and dendritic cells in glomerular immunopathology. Semin Immunopathol (2007) 1.08

Kidney dendritic cells in acute and chronic renal disease. Int J Exp Pathol (2010) 1.06

The innate functions of dendritic cells in peripheral lymphoid tissues. Adv Exp Med Biol (2005) 1.06

IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol (2002) 1.02

Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis. Mol Ther (2002) 1.01

IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. Eur J Immunol (1999) 1.01

In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival. Transplantation (2004) 0.98

Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice. Kidney Int (1997) 0.98

Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. J Am Soc Nephrol (2005) 0.94

An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. J Immunol (2004) 0.94

Review article: Kidney dendritic cells: their role in homeostasis, inflammation and transplantation. Nephrology (Carlton) (2009) 0.89

Effect of interleukin-10 treatment on crescentic glomerulonephritis in rats. Kidney Int (1997) 0.89

Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. J Am Soc Nephrol (2006) 0.87

Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis. J Am Soc Nephrol (2001) 0.87

Dendritic cells contribute to autoimmune kidney injury in MRL-Faslpr mice. J Rheumatol (2009) 0.86

Articles by these authors

Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med (2015) 4.78

An immunofluorescence test for phospholipase-A₂-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transplant (2011) 4.19

Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science (2007) 3.27

TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell (2010) 3.25

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol (2008) 3.08

Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood (2005) 2.81

Cross-priming in health and disease. Nat Rev Immunol (2010) 2.51

The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain (2012) 2.49

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice. Hepatology (2014) 2.45

Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol (2010) 2.38

The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo. Blood (2013) 2.34

Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology (2011) 2.14

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J Immunol (2006) 2.09

The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 2.06

Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int (2012) 2.06

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut (2011) 2.06

Living in the liver: hepatic infections. Nat Rev Immunol (2012) 2.03

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest (2009) 2.01

The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med (2009) 1.95

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol (2004) 1.94

In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma. Blood (2006) 1.92

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med (2002) 1.89

The renal mononuclear phagocytic system. J Am Soc Nephrol (2011) 1.84

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol (2010) 1.81

The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol (2013) 1.76

IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med (2013) 1.75

Endocytosis mechanisms and the cell biology of antigen presentation. Curr Opin Immunol (2008) 1.70

Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet (2012) 1.69

Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J Immunol (2013) 1.67

Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol (2010) 1.63

Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis. Nephrol Dial Transplant (2004) 1.61

Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells. J Immunol (2010) 1.59

Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. J Am Soc Nephrol (2013) 1.54

Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology (2008) 1.49

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol (2011) 1.49

Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur J Immunol (2006) 1.45

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods (2012) 1.40

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol (2008) 1.38

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol (2013) 1.37

NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol (2012) 1.35

CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J Am Soc Nephrol (2010) 1.34

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol (2009) 1.29

Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry. Nephrol Dial Transplant (2012) 1.29

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures. Nat Protoc (2010) 1.28

CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J Immunol (2008) 1.28

Origin of regenerating tubular cells after acute kidney injury. Proc Natl Acad Sci U S A (2014) 1.27

Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur J Immunol (2005) 1.27

Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis. Kidney Int (2008) 1.25

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology (2012) 1.25

CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis. J Immunol (2011) 1.25

Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver. J Leukoc Biol (2005) 1.24

The Th17 immune response in renal inflammation. Kidney Int (2010) 1.24

Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun (2006) 1.23

In vivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye. Invest Ophthalmol Vis Sci (2008) 1.22

Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness. J Biol Chem (2003) 1.19

BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. Kidney Int (2005) 1.16

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology (2013) 1.15

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J (2012) 1.14

Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis. Kidney Int (2012) 1.13

T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med (2010) 1.13

The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol (2008) 1.12

Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice. J Am Soc Nephrol (2007) 1.11

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. Eur J Immunol (2008) 1.11

Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology (2012) 1.11

Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization. J Immunol (2002) 1.10

Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells. Eur J Immunol (2009) 1.09

Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens. J Immunol (2005) 1.08

Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res (2012) 1.08

Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int (2012) 1.08

RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. Cell Rep (2013) 1.08

Role of T cells and dendritic cells in glomerular immunopathology. Semin Immunopathol (2007) 1.08

Podocytes are nonhematopoietic professional antigen-presenting cells. J Am Soc Nephrol (2013) 1.07

Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol (2007) 1.07

Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal. J Am Soc Nephrol (2004) 1.07

Kidney dendritic cells in acute and chronic renal disease. Int J Exp Pathol (2010) 1.06

Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II. J Allergy Clin Immunol (2009) 1.05

Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. J Immunol (2008) 1.05

The role of chemokines and their receptors in dendritic cell biology. Front Biosci (2008) 1.03

Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol (2011) 1.02