|
1
|
Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?
|
Stroke
|
2009
|
4.14
|
|
2
|
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
|
Ann Intern Med
|
2015
|
3.75
|
|
3
|
Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis.
|
Lancet
|
2009
|
2.81
|
|
4
|
Statins, low-density lipoprotein cholesterol, and risk of cancer.
|
J Am Coll Cardiol
|
2008
|
2.77
|
|
5
|
Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale: analysis of putative high-risk features from the risk of paradoxical embolism database.
|
Circ Cardiovasc Imaging
|
2013
|
2.56
|
|
6
|
Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis.
|
BMC Med Res Methodol
|
2006
|
2.27
|
|
7
|
Index event bias as an explanation for the paradoxes of recurrence risk research.
|
JAMA
|
2011
|
2.27
|
|
8
|
Predicting mortality in incident dialysis patients: an analysis of the United Kingdom Renal Registry.
|
Am J Kidney Dis
|
2011
|
2.01
|
|
9
|
Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach.
|
J Am Coll Cardiol
|
2010
|
1.93
|
|
10
|
Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study.
|
Stroke
|
2006
|
1.86
|
|
11
|
Predicting nursing home admission: estimates from a 7-year follow-up of a nationally representative sample of older Americans.
|
Alzheimer Dis Assoc Disord
|
2004
|
1.85
|
|
12
|
Potentially large yet uncertain benefits: a meta-analysis of patent foramen ovale closure trials.
|
Stroke
|
2013
|
1.81
|
|
13
|
Patent foramen ovale closure and medical treatments for secondary stroke prevention: a systematic review of observational and randomized evidence.
|
Stroke
|
2011
|
1.74
|
|
14
|
Elapsed time in emergency medical services for patients with cardiac complaints: are some patients at greater risk for delay?
|
Circ Cardiovasc Qual Outcomes
|
2009
|
1.71
|
|
15
|
Evidence of systematic duplication by new percutaneous coronary intervention programs.
|
Circ Cardiovasc Qual Outcomes
|
2013
|
1.66
|
|
16
|
Still no closure on the question of PFO closure.
|
N Engl J Med
|
2013
|
1.64
|
|
17
|
Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies.
|
Circ Cardiovasc Genet
|
2010
|
1.62
|
|
18
|
Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of Osteoarthritis Trials.
|
Ann Intern Med
|
2015
|
1.61
|
|
19
|
Reporting clinical trial results to inform providers, payers, and consumers.
|
Health Aff (Millwood)
|
2005
|
1.57
|
|
20
|
Personalised medicine: not just in our genes.
|
BMJ
|
2012
|
1.51
|
|
21
|
Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II.
|
Stroke
|
2006
|
1.47
|
|
22
|
Willingness-to-pay for predictive tests with no immediate treatment implications: a survey of US residents.
|
Health Econ
|
2010
|
1.43
|
|
23
|
Much cheaper, almost as good: decrementally cost-effective medical innovation.
|
Ann Intern Med
|
2009
|
1.40
|
|
24
|
Evidence-based medicine and the hard problem of multimorbidity.
|
J Gen Intern Med
|
2014
|
1.34
|
|
25
|
Risk prediction models for patients with chronic kidney disease: a systematic review.
|
Ann Intern Med
|
2013
|
1.33
|
|
26
|
The risk of paradoxical embolism (RoPE) study: initial description of the completed database.
|
Int J Stroke
|
2012
|
1.32
|
|
27
|
Comparative effectiveness of ST-segment-elevation myocardial infarction regionalization strategies.
|
Circ Cardiovasc Qual Outcomes
|
2010
|
1.28
|
|
28
|
Stroke--an equal opportunity for the initiation of statin therapy.
|
N Engl J Med
|
2006
|
1.22
|
|
29
|
A CTSA agenda to advance methods for comparative effectiveness research.
|
Clin Transl Sci
|
2011
|
1.21
|
|
30
|
Multimorbidity and evidence generation.
|
J Gen Intern Med
|
2014
|
1.17
|
|
31
|
Random treatment assignment using mathematical equipoise for comparative effectiveness trials.
|
Clin Transl Sci
|
2011
|
1.14
|
|
32
|
The empirical basis for determinations of medical futility.
|
J Gen Intern Med
|
2010
|
1.13
|
|
33
|
Using internally developed risk models to assess heterogeneity in treatment effects in clinical trials.
|
Circ Cardiovasc Qual Outcomes
|
2014
|
1.07
|
|
34
|
Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy.
|
Clin Infect Dis
|
2013
|
1.06
|
|
35
|
Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).
|
Heart Rhythm
|
2008
|
1.05
|
|
36
|
Benchmarks and determinants of adherence to stroke performance measures.
|
Stroke
|
2008
|
1.04
|
|
37
|
Patent foramen ovale and cryptogenic stroke.
|
N Engl J Med
|
2008
|
1.00
|
|
38
|
6 EZ steps to improving your performance: (or how to make P4P pay 4U!).
|
JAMA
|
2008
|
0.98
|
|
39
|
How to integrate multiple comorbidities in guideline development: article 10 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.
|
Proc Am Thorac Soc
|
2012
|
0.97
|
|
40
|
A geospatial analysis of emergency transport and inter-hospital transfer in ST-segment elevation myocardial infarction.
|
Am J Cardiol
|
2007
|
0.97
|
|
41
|
Are unadjusted analyses of clinical trials inappropriately biased toward the null?
|
Stroke
|
2009
|
0.95
|
|
42
|
Risk of arrhythmic and nonarrhythmic death in patients with heart failure and chronic kidney disease.
|
Am Heart J
|
2011
|
0.95
|
|
43
|
Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.
|
Genet Med
|
2010
|
0.94
|
|
44
|
Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.
|
Alzheimers Dement
|
2012
|
0.94
|
|
45
|
Out-of-hospital use of proton pump inhibitors and hypomagnesemia at hospital admission: a nested case-control study.
|
Am J Kidney Dis
|
2013
|
0.94
|
|
46
|
The Surgical Apgar Score in hip and knee arthroplasty.
|
Clin Orthop Relat Res
|
2010
|
0.94
|
|
47
|
Aggregating and disaggregating patients in clinical trials and their subgroup analyses.
|
Ann Intern Med
|
2010
|
0.90
|
|
48
|
Controversies in cardioembolic stroke.
|
Curr Treat Options Cardiovasc Med
|
2015
|
0.90
|
|
49
|
25-hydroxyvitamin D levels and juvenile idiopathic arthritis: is there an association with disease activity?
|
Rheumatol Int
|
2011
|
0.85
|
|
50
|
Effects of chemotherapy on survival of elderly patients with small-cell lung cancer: analysis of the SEER-medicare database.
|
J Thorac Oncol
|
2013
|
0.84
|
|
51
|
Rethinking trial strategies for stroke and patent foramen ovale.
|
Curr Opin Neurol
|
2010
|
0.84
|
|
52
|
Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale.
|
Stroke
|
2013
|
0.84
|
|
53
|
The potential of training to increase acceptance and use of computerized decision support systems for medical diagnosis.
|
Hum Factors
|
2006
|
0.82
|
|
54
|
Stroke prevention--insights from incoherence.
|
N Engl J Med
|
2008
|
0.82
|
|
55
|
Gender differences in tPA-related arterial recanalization.
|
Stroke
|
2005
|
0.82
|
|
56
|
The Stroke Practice Improvement Network: a quasiexperimental trial of a multifaceted intervention to improve quality.
|
J Stroke Cerebrovasc Dis
|
2010
|
0.82
|
|
57
|
Multiple chronic conditions in type 2 diabetes mellitus: prevalence and consequences.
|
Am J Manag Care
|
2015
|
0.79
|
|
58
|
Primary angioplasty or thrombolysis for acute myocardial infarction?
|
Lancet
|
2003
|
0.78
|
|
59
|
Detecting mood disorder in resource-limited primary care settings: comparison of a self-administered screening tool to general practitioner assessment.
|
J Med Screen
|
2013
|
0.78
|
|
60
|
The Lake Wobegon Effect: Why Most Patients Are at Below-Average Risk.
|
Ann Intern Med
|
2015
|
0.78
|
|
61
|
Accounting for center effects in multicenter trials.
|
Epidemiology
|
2010
|
0.77
|
|
62
|
Personalizing evidence-based primary prevention with aspirin: individualized risks and patient preference.
|
Circ Cardiovasc Qual Outcomes
|
2011
|
0.77
|
|
63
|
Improved perioperative outcomes from carotid endarterectomy: yet another statin side effect?
|
Stroke
|
2005
|
0.77
|
|
64
|
The RoPE Score and Right-to-Left Shunt Severity by Transcranial Doppler in the CODICIA Study.
|
Cerebrovasc Dis
|
2015
|
0.77
|
|
65
|
Drug and device effects on peak oxygen consumption, 6-minute walk distance, and natriuretic peptides as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction.
|
Circ Heart Fail
|
2011
|
0.77
|
|
66
|
Pharmacologic interventions for knee osteoarthritis.
|
Ann Intern Med
|
2015
|
0.75
|
|
67
|
Prognostic models for older adults.
|
JAMA
|
2012
|
0.75
|
|
68
|
Towards an epidemiology of the known unknowns in cryptogenic stroke.
|
Heart
|
2012
|
0.75
|
|
69
|
Patent foramen ovale and cryptogenic stroke.
|
N Engl J Med
|
2013
|
0.75
|
|
70
|
Baseline characteristics predict risk of progression and response to combined medical therapy for benign prostatic hyperplasia (BPH).
|
BJU Int
|
2014
|
0.75
|
|
71
|
Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eye.
|
J Investig Med
|
2006
|
0.75
|
|
72
|
Sex Versus Gender in Recurrent Events Following Acute Coronary Syndrome: A "Femininity Paradox?".
|
J Am Coll Cardiol
|
2016
|
0.75
|
|
73
|
Differences in response to reperfusion therapies in acute stroke between men and women: mediated by sex or by chance?
|
Stroke
|
2006
|
0.75
|
|
74
|
Implantable or external defibrillators for individuals at increased risk of cardiac arrest: where cost-effectiveness hits fiscal reality.
|
Value Health
|
2006
|
0.75
|