Published in Eur J Med Chem on November 24, 2010
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks. Neoplasia (2015) 0.79
A quantitative structure-activity relationship study of anti-HIV activity of substituted HEPT using nonlinear models. Med Chem Res (2013) 0.75
Curated human hyperbilirubinemia data and the respective OATP1B1 and 1B3 inhibition predictions. Data Brief (2017) 0.75
Predicting Drug-Induced Cholestasis with the Help of Hepatic Transporters-An in Silico Modeling Approach. J Chem Inf Model (2017) 0.75
Estimating sensory irritation potency of volatile organic chemicals using QSARs based on decision tree methods for regulatory purpose. Ecotoxicology (2015) 0.75
Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
A multidisciplinary decision support system for forest fire crisis management. Environ Manage (2004) 3.32
Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest (2002) 2.85
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem (2001) 2.76
Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol (2010) 2.70
Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab (2008) 2.44
The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest (2009) 2.42
Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Ann Rheum Dis (2013) 2.40
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol (2008) 2.32
HuR as a negative posttranscriptional modulator in inflammation. Mol Cell (2005) 2.27
Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol (2005) 2.19
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity (2006) 2.10
Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med (2008) 1.98
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci U S A (2011) 1.95
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med (2002) 1.94
Collaborative development of predictive toxicology applications. J Cheminform (2010) 1.91
Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. J Exp Med (2012) 1.76
Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources. Mamm Genome (2007) 1.75
Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum (2002) 1.72
Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity (2003) 1.72
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med (2004) 1.67
Models for financial sustainability of biological databases and resources. Database (Oxford) (2009) 1.64
Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med (2009) 1.49
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (2005) 1.34
Soluble TNF mediates the transition from pulmonary inflammation to fibrosis. PLoS One (2006) 1.32
Cellular mechanisms of TNF function in models of inflammation and autoimmunity. Curr Dir Autoimmun (2010) 1.29
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis. Am J Pathol (2004) 1.24
Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology (2008) 1.23
Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol (2006) 1.17
Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology. Proc Natl Acad Sci U S A (2011) 1.11
Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol (2009) 1.10
Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation. J Bone Miner Res (2004) 1.09
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. Cancer Cell (2012) 1.09
The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol (2009) 1.06
Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann Rheum Dis (2012) 1.06
Loss of downregulated in adenoma (DRA) impairs mucosal HCO3(-) secretion in murine ileocolonic inflammation. Inflamm Bowel Dis (2011) 1.05
Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study. Arthritis Res Ther (2004) 1.05
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest (2012) 1.05
A novel QSAR model for predicting induction of apoptosis by 4-aryl-4H-chromenes. Bioorg Med Chem (2006) 1.04
Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption. FASEB J (2005) 1.04
Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum (2010) 1.03
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity (2013) 1.03
Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo. Eur J Immunol (2002) 1.02
Functional analysis of an arthritogenic synovial fibroblast. Arthritis Res Ther (2003) 1.02
Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo. J Virol (2004) 1.01
Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters. Inflamm Bowel Dis (2008) 1.01
Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model. J Proteome Res (2011) 1.01
Multivesicular bodies in intestinal epithelial cells: responsible for MHC class II-restricted antigen processing and origin of exosomes. Immunology (2008) 1.00
Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity (2009) 0.99
The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis. Arthritis Rheum (2012) 0.99
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis. PLoS Genet (2005) 0.97
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest (2013) 0.96
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. Toxicol Appl Pharmacol (2013) 0.96
MK2 regulates the early stages of skin tumor promotion. Carcinogenesis (2009) 0.95
Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci U S A (2003) 0.94
Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia. PLoS One (2012) 0.92
Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice. J Neurosci Res (2003) 0.91
QSAR study on para-substituted aromatic sulfonamides as carbonic anhydrase II inhibitors using topological information indices. Bioorg Med Chem (2005) 0.89
Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules. PLoS One (2012) 0.88
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity. Toxicol Appl Pharmacol (2012) 0.88
Overexpression of tumor necrosis factor causes bilateral sacroiliitis. Arthritis Rheum (2004) 0.88
A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet (2011) 0.86
Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection. Immunology (2008) 0.86
In silico exploration for identifying structure-activity relationship of MEK inhibition and oral bioavailability for isothiazole derivatives. Chem Biol Drug Des (2010) 0.84
Identification of a series of novel derivatives as potent HCV inhibitors by a ligand-based virtual screening optimized procedure. Bioorg Med Chem (2007) 0.84
Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice. J Neurosci Res (2007) 0.84
Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols. Arthritis Res Ther (2003) 0.84
TNFR2 on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE. Eur J Immunol (2011) 0.83
Mouse Resource Browser--a database of mouse databases. Database (Oxford) (2010) 0.83
A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas. Eur J Med Chem (2008) 0.83
Investigation of substituent effect of 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides on CCR5 binding affinity using QSAR and virtual screening techniques. J Comput Aided Mol Des (2006) 0.82
Tumor necrosis factor biology in experimental and clinical arthritis. Curr Opin Rheumatol (2003) 0.82
Two-step total syntheses of canthin-6-one alkaloids: new one-pot sequential Pd-catalyzed Suzuki-Miyaura coupling and Cu-catalyzed amidation reaction. Org Lett (2010) 0.82
Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: potential importance for cartilage breakdown and synovial hypertrophy. Arthritis Rheum (2008) 0.82
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice. Arthritis Rheum (2008) 0.81
Functionalized 4-hydroxy coumarins: novel synthesis, crystal structure and DFT calculations. Molecules (2011) 0.81
A novel simple QSAR model for the prediction of anti-HIV activity using multiple linear regression analysis. Mol Divers (2006) 0.81
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur J Med Chem (2013) 0.81
Electrocardiographic and electrophysiologic characteristics of ventricular extrasystoles arising from the aortomitral continuity. Cardiol Res Pract (2011) 0.81
A new role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis. Adv Exp Med Biol (2011) 0.81
New regiospecific isothiazole C-C coupling chemistry. Org Biomol Chem (2006) 0.81
An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells. J Immunol (2007) 0.81
Predictive QSAR workflow for the in silico identification and screening of novel HDAC inhibitors. Mol Divers (2009) 0.80
Genetic engineering in the mouse: tuning TNF/TNFR expression. Methods Mol Med (2004) 0.80
Invariant natural killer T cells are natural regulators of murine spondylarthritis. Arthritis Rheum (2010) 0.80