Published in Mol Vis on December 17, 2010
The mutation V42M distorts the compact packing of the human gamma-S-crystallin molecule, resulting in congenital cataract. PLoS One (2012) 0.87
Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparency. PLoS One (2013) 0.86
Structural analysis of the mutant protein D26G of human γS-crystallin, associated with Coppock cataract. Mol Vis (2013) 0.80
Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses. Hum Genomics (2012) 0.77
Association properties and unfolding of a βγ-crystallin domain of a Vibrio-specific protein. PLoS One (2013) 0.76
In vitro unfolding, refolding, and polymerization of human gammaD crystallin, a protein involved in cataract formation. Protein Sci (2003) 1.76
Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin. Biochemistry (2005) 1.50
His-tag impact on structure. Acta Crystallogr D Biol Crystallogr (2007) 1.43
Altered phase diagram due to a single point mutation in human gammaD-crystallin. Proc Natl Acad Sci U S A (2007) 1.32
Folding and stability of the isolated Greek key domains of the long-lived human lens proteins gammaD-crystallin and gammaS-crystallin. Protein Sci (2007) 1.30
The structure of the cataract-causing P23T mutant of human gammaD-crystallin exhibits distinctive local conformational and dynamic changes. Biochemistry (2009) 1.25
Two affected siblings with nuclear cataract associated with a novel missense mutation in the CRYGD gene. Mol Vis (2006) 1.20
Increase in surface hydrophobicity of the cataract-associated P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility. Biochemistry (2010) 1.15
Detection and characterization of protein aggregates by fluorescence microscopy. Int J Pharm (2006) 1.09
GammaD-crystallin associated protein aggregation and lens fiber cell denucleation. Invest Ophthalmol Vis Sci (2007) 1.06
Novel mutation in the gamma-S crystallin gene causing autosomal dominant cataract. Mol Vis (2009) 1.05
Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS). PLoS One (2010) 1.05
NMR study of the cataract-linked P23T mutant of human gammaD-crystallin shows minor changes in hydrophobic patches that reflect its retrograde solubility. Biochem Biophys Res Commun (2009) 1.03
beta-Strand interactions at the domain interface critical for the stability of human lens gammaD-crystallin. Protein Sci (2010) 1.03
Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red. J Fluoresc (2007) 1.02
Visualization of in situ intracellular aggregation of two cataract-associated human gamma-crystallin mutants: lose a tail, lose transparency. Invest Ophthalmol Vis Sci (2008) 0.90
A novel human CRYGD mutation in a juvenile autosomal dominant cataract. Mol Vis (2010) 0.90
Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P gamma C-crystallin. Exp Cell Res (2006) 0.89
Protein-protein interactions involving congenital cataract T5P gammaC-crystallin mutant: a confocal fluorescence microscopy study. Exp Eye Res (2008) 0.88
Structure and stability of gamma-crystallins--IV. Aggregation and structural destabilization in photosensitized reactions. Photochem Photobiol (1988) 0.81
Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency. Br J Ophthalmol (2012) 1.73
Clinical outcomes of xeno-free autologous cultivated limbal epithelial transplantation: a 10-year study. Br J Ophthalmol (2011) 1.66
Molecular and cellular assessment of ginkgo biloba extract as a possible ophthalmic drug. Exp Eye Res (2002) 1.48
Smoking and its association with cataract: results of the Andhra Pradesh eye disease study from India. Invest Ophthalmol Vis Sci (2005) 1.24
Mutation spectrum of the CYP1B1 gene in Indian primary congenital glaucoma patients. Mol Vis (2004) 1.19
Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees. Invest Ophthalmol Vis Sci (2002) 1.18
Mutation spectrum of FOXC1 and clinical genetic heterogeneity of Axenfeld-Rieger anomaly in India. Mol Vis (2003) 1.10
A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Invest Ophthalmol Vis Sci (2007) 1.02
In vitro culture and expansion of human limbal epithelial cells. Nat Protoc (2010) 1.02
Mie light scattering calculations for an Indian age-related nuclear cataract with a high density of multilamellar bodies. Mol Vis (2008) 0.99
Identification of R368H as a predominant CYP1B1 allele causing primary congenital glaucoma in Indian patients. Invest Ophthalmol Vis Sci (2003) 0.98
Focus on molecules: optineurin. Exp Eye Res (2007) 0.96
Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans. Biophys J (2006) 0.95
Mutation causing self-aggregation in human gammaC-crystallin leading to congenital cataract. Invest Ophthalmol Vis Sci (2006) 0.95
Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. BMC Cell Biol (2010) 0.93
Ultrastructural analysis of damage to nuclear fiber cell membranes in advanced age-related cataracts from India. Exp Eye Res (2008) 0.92
Microsporidial keratitis in India: 16S rRNA gene-based PCR assay for diagnosis and species identification of microsporidia in clinical samples. Invest Ophthalmol Vis Sci (2006) 0.92
Visualization of in situ intracellular aggregation of two cataract-associated human gamma-crystallin mutants: lose a tail, lose transparency. Invest Ophthalmol Vis Sci (2008) 0.90
Optineurin and its mutants: molecules associated with some forms of glaucoma. Ophthalmic Res (2009) 0.89
The mutation V42M distorts the compact packing of the human gamma-S-crystallin molecule, resulting in congenital cataract. PLoS One (2012) 0.87
Multilamellar spherical particles as potential sources of excessive light scattering in human age-related nuclear cataracts. Exp Eye Res (2010) 0.86
Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparency. PLoS One (2013) 0.86
Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India. Mol Vis (2003) 0.85
Peroxynitrite reaction with eye lens proteins: alpha-crystallin retains its activity despite modification. Invest Ophthalmol Vis Sci (2004) 0.84
Structural analysis of the mutant protein D26G of human γS-crystallin, associated with Coppock cataract. Mol Vis (2013) 0.80
Oral epithelial cells transplanted on to corneal surface tend to adapt to the ocular phenotype. Indian J Ophthalmol (2014) 0.79
Role of xanthurenic acid 8-O-beta-D-glucoside, a novel fluorophore that accumulates in the brunescent human eye lens. Photochem Photobiol (2002) 0.76
Gene symbol: CYP1B1. Disease: glaucoma, primary congenital. Hum Genet (2003) 0.76
Functional analysis of optineurin and some of its disease-associated mutants. IUBMB Life (2015) 0.76
Gene symbol: MY0C (GLC1A). Disease: glaucoma 1, open angle. Hum Genet (2003) 0.75
Corneal chalcosis following blast injury. Br J Ophthalmol (2012) 0.75