| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.
|
J Med Chem
|
2007
|
1.06
|
|
2
|
Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides.
|
Bioorg Med Chem
|
2008
|
0.91
|
|
3
|
Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.
|
Antimicrob Agents Chemother
|
2008
|
0.91
|
|
4
|
In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.
|
J Antimicrob Chemother
|
2008
|
0.89
|
|
5
|
Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships.
|
Exp Parasitol
|
2011
|
0.86
|
|
6
|
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.
|
Bioorg Med Chem
|
2008
|
0.84
|
|
7
|
Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives.
|
Eur J Med Chem
|
2010
|
0.84
|
|
8
|
Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.
|
J Med Chem
|
2002
|
0.83
|
|
9
|
Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.
|
Bioorg Med Chem Lett
|
2007
|
0.83
|
|
10
|
3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.
|
J Med Chem
|
2011
|
0.81
|
|
11
|
New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.
|
Bioorg Med Chem
|
2010
|
0.81
|
|
12
|
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents.
|
Bioorg Med Chem Lett
|
2011
|
0.80
|
|
13
|
Quinoxaline 1,4-di-N-oxide and the potential for treating tuberculosis.
|
Infect Disord Drug Targets
|
2011
|
0.79
|
|
14
|
Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.
|
Molecules
|
2009
|
0.79
|
|
15
|
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities.
|
Molecules
|
2013
|
0.78
|
|
16
|
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities.
|
Bioorg Med Chem Lett
|
2011
|
0.78
|
|
17
|
Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives.
|
Exp Parasitol
|
2011
|
0.78
|
|
18
|
Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents.
|
Bioorg Med Chem
|
2010
|
0.78
|
|
19
|
Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents.
|
Eur J Med Chem
|
2013
|
0.77
|
|
20
|
Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives.
|
Molecules
|
2012
|
0.76
|
|
21
|
Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.
|
Molecules
|
2008
|
0.75
|
|
22
|
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies.
|
Eur J Med Chem
|
2012
|
0.75
|
|
23
|
Studies on log Po/w of quinoxaline di-N-oxides: a comparison of RP-HPLC experimental and predictive approaches.
|
Molecules
|
2011
|
0.75
|
|
24
|
New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
|
Arzneimittelforschung
|
2008
|
0.75
|
|
25
|
Challenges in Chagas Disease Drug Discovery: A Review.
|
Curr Med Chem
|
2016
|
0.75
|
|
26
|
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands.
|
Molecules
|
2012
|
0.75
|
|
27
|
Unexpected reduction of ethyl 3-phenylquinoxaline-2- carboxylate 1,4-di-N-oxide derivatives by amines.
|
Molecules
|
2008
|
0.75
|
|
28
|
Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives.
|
Molecules
|
2008
|
0.75
|
|
29
|
Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
|
J Med Chem
|
2017
|
0.75
|