Published in Anticancer Res on January 01, 2011
The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS One (2012) 1.26
TLR4 activates the β-catenin pathway to cause intestinal neoplasia. PLoS One (2013) 1.10
LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. Carcinogenesis (2013) 1.06
Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. World J Surg Oncol (2012) 1.06
DCLK1 immunoreactivity in colorectal neoplasia. Clin Exp Gastroenterol (2012) 0.99
Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. Int J Clin Exp Pathol (2011) 0.99
H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer. Dig Dis Sci (2012) 0.96
Characterization of LGR5 stem cells in colorectal adenomas and carcinomas. Sci Rep (2015) 0.95
Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer. Br J Cancer (2014) 0.88
Intestinal stem cell marker LGR5 expression during gastric carcinogenesis. World J Gastroenterol (2013) 0.88
Wnt signaling in cancer stem cells and colon cancer metastasis. F1000Res (2016) 0.84
LGR5 is a promising biomarker for patients with stage I and II gastric cancer. Chin J Cancer Res (2013) 0.84
Single nucleotide polymorphisms of the adult intestinal stem cell marker Lgr5 in primary and metastatic colorectal cancer. Am J Transl Res (2012) 0.84
Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells. PLoS One (2014) 0.83
Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche. Proc Natl Acad Sci U S A (2011) 0.82
The regulatory niche of intestinal stem cells. J Physiol (2016) 0.79
Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. BMC Cancer (2015) 0.78
PKH26 staining defines distinct subsets of normal human colon epithelial cells at different maturation stages. PLoS One (2012) 0.77
Lgr5 is a potential prognostic marker in patients with cervical carcinoma. Int J Clin Exp Pathol (2015) 0.77
Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. BMC Cancer (2016) 0.75
Lgr5-positive cells in the lung and their clinical significance in patients with lung adenocarcinoma. Mol Clin Oncol (2016) 0.75
LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy. Pharmacogenomics J (2015) 0.75
Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence. Oncotarget (2017) 0.75
Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors. Virchows Arch (2017) 0.75
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med (2010) 27.12
Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol (2005) 5.10
B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res (2004) 4.65
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol (2012) 3.57
Phase I/II study of concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: Japan Clinical Oncology Group Study JCOG0211. J Clin Oncol (2009) 3.12
Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. Clin Cancer Res (2005) 2.97
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet (2008) 2.89
Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade. Hum Pathol (2002) 2.45
Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer (2006) 2.11
Neuroendocrine neoplasms of the lung: a prognostic spectrum. J Clin Oncol (2006) 2.11
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci U S A (2011) 2.08
Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation. Blood (2010) 2.04
Feasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapy. Int J Radiat Oncol Biol Phys (2003) 2.00
Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg (2002) 1.91
Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer. BMC Cancer (2007) 1.85
Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results. Ann Surg (2007) 1.83
CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma. Cancer Res (2003) 1.83
CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers. Cancer Sci (2003) 1.78
Modified scar grade: a prognostic indicator in small peripheral lung adenocarcinoma. Cancer (2002) 1.66
Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers. Carcinogenesis (2004) 1.65
Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int J Radiat Oncol Biol Phys (2003) 1.63
Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg (2003) 1.55
The role of lymph-node dissection in the treatment of upper urinary tract cancer: a multi-institutional study. BJU Int (2008) 1.53
Oncological benefit of preoperative endoscopic biliary drainage in patients with hilar cholangiocarcinoma. J Hepatobiliary Pancreat Sci (2014) 1.49
Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung. Cancer Sci (2007) 1.47
Small cell carcinoma of the lung exclusively localized within the left descending pulmonary artery. Chest (2005) 1.42
Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortality. J Hepatobiliary Pancreat Sci (2009) 1.38
Suppressive effect of modified dominant negative RAS mutant on human cancer by gene transfer with non-viral vector. Cancer Biol Ther (2006) 1.38
ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting. J Thorac Oncol (2014) 1.37
Grade of stromal invasion in small adenocarcinoma of the lung: histopathological minimal invasion and prognosis. Am J Surg Pathol (2004) 1.36
Detection of EGFR mutations in archived cytologic specimens of non-small cell lung cancer using high-resolution melting analysis. Am J Clin Pathol (2006) 1.36
Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non small cell lung cancer treated with gefitinib. Clin Cancer Res (2007) 1.34
Lung adenocarcinoma presenting with enlarged and multiloculated cystic lesions over 2 years. Respir Care (2004) 1.31
Primary bone lymphoma: a new and detailed characterization of 28 patients in a single-institution study. Jpn J Clin Oncol (2007) 1.31
A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions. Ann Thorac Surg (2003) 1.29
Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. Am J Pathol (2002) 1.19
Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization. Am J Surg Pathol (2003) 1.19
Malignant glomus tumor of the lung. Pathol Int (2003) 1.18
A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology (2010) 1.17
Mediastinal lymph node staging by FDG-PET in patients with non-small cell lung cancer: analysis of false-positive FDG-PET findings. Respiration (2003) 1.17
HLA class I antigen expression is associated with a favorable prognosis in early stage non-small cell lung cancer. Cancer Sci (2007) 1.16
Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol (2002) 1.15
Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res (2005) 1.15
Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma. Cancer (2006) 1.15
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer (2012) 1.15
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers. Cancer Epidemiol Biomarkers Prev (2002) 1.14
Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma. Cancer Res (2004) 1.14
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L. Lung Cancer (2006) 1.13
Validity and reproducibility of histologic diagnosis and grading for adult soft-tissue sarcomas. Hum Pathol (2002) 1.13
Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol (2006) 1.12
Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma. Cancer Sci (2009) 1.12
Clinicopathological analysis of early-stage gastric cancers detected after successful eradication of Helicobacter pylori. Helicobacter (2011) 1.12
Minute pulmonary meningothelial-like nodules: clinicopathologic analysis of 121 patients. Hum Pathol (2009) 1.11
Multiple lung adenocarcinomas showing ground-glass opacities on thoracic computed tomography. Ann Thorac Surg (2006) 1.10
Primary mediastinal large B-cell lymphoma: a single-institution clinical study in Japan. Int J Hematol (2004) 1.10
Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer. Clin Cancer Res (2005) 1.08
CT-guided transbronchial biopsy using an ultrathin bronchoscope with virtual bronchoscopic navigation. Chest (2004) 1.08
Insertion and fixation of fiducial markers for setup and tracking of lung tumors in radiotherapy. Int J Radiat Oncol Biol Phys (2005) 1.08
Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors. Arch Pathol Lab Med (2008) 1.07
Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer (2002) 1.07
The effect of tumor location and respiratory function on tumor movement estimated by real-time tracking radiotherapy (RTRT) system. Int J Radiat Oncol Biol Phys (2005) 1.07
Co-expression of mesothelin and CA125 correlates with unfavorable patient outcome in pancreatic ductal adenocarcinoma. Pancreas (2011) 1.06
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung. Lung Cancer (2005) 1.06
Autoimmune pancreatitis associated with hemorrhagic pseudocysts: a case report and literature review. Intern Med (2008) 1.06
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. Chest (2005) 1.06
Clinical responses of large cell neuroendocrine carcinoma of the lung to cisplatin-based chemotherapy. Lung Cancer (2005) 1.06
Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice. Clin Cancer Res (2005) 1.04
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response. J Surg Oncol (2003) 1.03
Endobronchial ultrasonography with a guide sheath in the diagnosis of benign peripheral diseases. Ann Thorac Surg (2012) 1.03
Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. J Biol Chem (2005) 1.02
AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets. Oncogene (2003) 1.01
Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos. Dev Biol (2003) 1.00
Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma. Cancer Sci (2007) 1.00
Frequent EGFR mutations in noninvasive bronchioloalveolar carcinoma. Int J Cancer (2006) 0.99
Proteomic signature corresponding to the response to gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor in lung adenocarcinoma. Clin Cancer Res (2007) 0.99
Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma. Oncol Rep (2010) 0.99
Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: quality of life analysis of North East Japan Study Group 002 Trial. Oncologist (2012) 0.98
Beta-catenin mutations in pulmonary blastomas: association with morule formation. J Pathol (2003) 0.98
Development and validation of diagnostic prediction model for solitary pulmonary nodules. Respirology (2007) 0.98
Real-time tumor-tracking radiation therapy for lung carcinoma by the aid of insertion of a gold marker using bronchofiberscopy. Cancer (2002) 0.98
Esophageal delta-shaped anastomosis: a new method of stapled anastomosis for the cervical esophagus and digestive tract. Surg Today (2005) 0.97
CD133 expression: a potential prognostic marker for non-small cell lung cancers. Int J Clin Oncol (2013) 0.96
Impact of diagnostic ureteroscopy on intravesical recurrence and survival in patients with urothelial carcinoma of the upper urinary tract. J Urol (2010) 0.96
Gonadotropin-releasing hormone I analog acts as an antiapoptotic factor in mouse blastocysts. Endocrinology (2005) 0.96