Published in J Pharm Sci on February 01, 2011
Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies. MAbs (2012) 1.07
Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes. MAbs (2014) 0.93
In vitro and in vivo modifications of recombinant and human IgG antibodies. MAbs (2014) 0.88
A chemical and computational approach to comprehensive glycation characterization on antibodies. MAbs (2015) 0.79
Impact of glycation on antibody clearance. AAPS J (2014) 0.76
Biophysical comparability of the same protein from different manufacturers: a case study using Epoetin alfa from Epogen and Eprex. J Pharm Sci (2006) 1.60
Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies. Anal Chem (2006) 1.15
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses. J Biol Chem (2012) 1.09
ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module. J Mol Biol (2004) 1.09
Glutamine-linked and non-consensus asparagine-linked oligosaccharides present in human recombinant antibodies define novel protein glycosylation motifs. J Biol Chem (2010) 1.04
Peptide cysteine thiyl radicals abstract hydrogen atoms from surrounding amino acids: the photolysis of a cystine containing model peptide. J Phys Chem B (2008) 1.04
Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis. Anal Biochem (2006) 1.03
An improved trypsin digestion method minimizes digestion-induced modifications on proteins. Anal Biochem (2009) 0.99
Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and alpha C-H bonds in insulin: control of selectivity by secondary structure. J Phys Chem B (2008) 0.97
Asparagine-linked oligosaccharides present on a non-consensus amino acid sequence in the CH1 domain of human antibodies. J Biol Chem (2009) 0.97
Biochemical assessment of erythropoietin products from Asia versus US Epoetin alfa manufactured by Amgen. J Pharm Sci (2009) 0.96
Aggregation of granulocyte-colony stimulating factor in vitro involves a conformationally altered monomeric state. Protein Sci (2005) 0.96
Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs. J Am Soc Mass Spectrom (2008) 0.95
Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution. J Pharm Sci (2004) 0.95
Removal of cysteinylation from an unpaired sulfhydryl in the variable region of a recombinant monoclonal IgG1 antibody improves homogeneity, stability, and biological activity. J Pharm Sci (2008) 0.94
Small-angle neutron scattering study of a monoclonal antibody using free-energy constraints. J Phys Chem B (2013) 0.93
Exposure of a monoclonal antibody, IgG1, to UV-light leads to protein dithiohemiacetal and thioether cross-links: a role for thiyl radicals? Chem Res Toxicol (2010) 0.91
Photolysis of an intrachain peptide disulfide bond: primary and secondary processes, formation of H2S, and hydrogen transfer reactions. J Phys Chem B (2010) 0.91
Anion binding and controlled aggregation of human interleukin-1 receptor antagonist. Biochemistry (2005) 0.91
Reversible hydrogen transfer between cysteine thiyl radical and glycine and alanine in model peptides: covalent H/D exchange, radical-radical reactions, and L- to D-Ala conversion. J Phys Chem B (2010) 0.90
Paraffin-wax-coated plates as matrix-assisted laser desorption/ionization sample support for high-throughput identification of proteins by peptide mass fingerprinting. Anal Biochem (2004) 0.89
Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine. J Phys Chem B (2011) 0.89
Screening and sequencing of glycated proteins by neutral loss scan LC/MS/MS method. Anal Chem (2007) 0.88
Secondary structures of proteins adsorbed onto aluminum hydroxide: infrared spectroscopic analysis of proteins from low solution concentrations. Anal Biochem (2006) 0.87
Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements. J Pharm Sci (2012) 0.87
Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist. Biochemistry (2006) 0.86
Reversed-phase liquid chromatography-mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments. J Chromatogr A (2007) 0.86
The triplet-state lifetime of indole derivatives in aqueous solution. Photochem Photobiol (2004) 0.85
Detection and quantitation of IgG 1 hinge aspartate isomerization: a rapid degradation in stressed stability studies. Anal Chem (2009) 0.85
The effect of sucrose hydrolysis on the stability of protein therapeutics during accelerated formulation studies. J Pharm Sci (2009) 0.85
Entanglement model of antibody viscosity. J Phys Chem B (2014) 0.85
O-fucosylation of an antibody light chain: characterization of a modification occurring on an IgG1 molecule. Glycobiology (2008) 0.84
Screening of monoclonal antibody formulations based on high-throughput thermostability and viscosity measurements: design of experiment and statistical analysis. J Pharm Sci (2010) 0.84
LC/MS analysis of complex multiglycosylated human alpha(1)-acid glycoprotein as a model for developing identification and quantitation methods for intact glycopeptide analysis. Anal Biochem (2010) 0.84
Physical and biophysical effects of polysorbate 20 and 80 on darbepoetin alfa. J Pharm Sci (2009) 0.84
Effect of sugar molecules on the viscosity of high concentration monoclonal antibody solutions. Pharm Res (2011) 0.83
Formulation of Neulasta (pegfilgrastim). Adv Drug Deliv Rev (2007) 0.83
Development of a human antibody tolerant mouse model to assess the immunogenicity risk due to aggregated biotherapeutics. J Pharm Sci (2013) 0.82
Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations. J Pharm Sci (2005) 0.82
The photolysis of disulfide bonds in IgG1 and IgG2 leads to selective intramolecular hydrogen transfer reactions of cysteine Thiyl radicals, probed by covalent H/D exchange and RPLC-MS/MS analysis. Pharm Res (2013) 0.82
Effect of pH and light on aggregation and conformation of an IgG1 mAb. Mol Pharm (2012) 0.81
Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation. Mol Pharm (2014) 0.81
Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry. Anal Biochem (2008) 0.81
Optimization and applications of CDAP labeling for the assignment of cysteines. Pharm Res (2005) 0.81
Methods of high throughput biophysical characterization in biopharmaceutical development. Curr Drug Discov Technol (2013) 0.81
Reversed-phase liquid chromatography of immunoglobulin G molecules and their fragments with the diphenyl column. J Chromatogr A (2007) 0.81
Viscoelastic characterization of high concentration antibody formulations using quartz crystal microbalance with dissipation monitoring. J Pharm Sci (2009) 0.81
Characterization of the binding site for inhibitors of the HPV11 E1-E2 protein interaction on the E2 transactivation domain by photoaffinity labeling and mass spectrometry. Anal Chem (2004) 0.80
Automated tryptic digestion procedure for HPLC/MS/MS peptide mapping of immunoglobulin gamma antibodies in pharmaceutics. J Pharm Biomed Anal (2008) 0.80
Light-induced aggregation of type I soluble tumor necrosis factor receptor. J Pharm Sci (2009) 0.79
A quantitative kinetic study of polysorbate autoxidation: the role of unsaturated fatty acid ester substituents. Pharm Res (2009) 0.79
Structural features responsible for the biological stability of Histoplasma's virulence factor CBP. Biochemistry (2008) 0.79
Improving mass accuracy of high performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry of intact antibodies. J Am Soc Mass Spectrom (2006) 0.78
Light-induced conversion of Trp to Gly and Gly hydroperoxide in IgG1. Mol Pharm (2013) 0.78
Middle-down fragmentation for the identification and quantitation of site-specific methionine oxidation in an IgG1 molecule. J Pharm Sci (2010) 0.77
Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. J Pharm Sci (2011) 0.77
Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature. J Pharm Sci (2013) 0.77
Fluorogenic tagging methodology applied to characterize oxidized tyrosine and phenylalanine in an immunoglobulin monoclonal antibody. Pharm Res (2013) 0.76
Characterization of an oncolytic herpes simplex virus drug candidate. J Pharm Sci (2014) 0.76
Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics. Protein Sci (2010) 0.76
Degradation products analysis of an Fc fusion protein using LC/MS methods. Int J Biol Macromol (2008) 0.76
A high-throughput UPLC method for the characterization of chemical modifications in monoclonal antibody molecules. J Pharm Sci (2011) 0.76
Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies. Protein Sci (2013) 0.75
Oxidation of free L-histidine by tert-Butylhydroperoxide. Pharm Res (2010) 0.75
A deoxygenation system for measuring protein phosphorescence. Anal Biochem (2004) 0.75
Optimized UV detection of high-concentration antibody formulations using high-throughput SE-HPLC. J Pharm Sci (2014) 0.75
Designed experiments with binary responses. J Pharm Sci (2011) 0.75
Effects of sucrose and benzyl alcohol on GCSF conformational dynamics revealed by hydrogen deuterium exchange mass spectrometry. J Pharm Sci (2015) 0.75