PubRank

Johan Weigelt

Author PubWeight™ 27.29‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A 2006 4.45
2 Protein production and purification. Nat Methods 2008 3.97
3 In situ proteolysis for protein crystallization and structure determination. Nat Methods 2007 3.05
4 Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nat Biotechnol 2012 2.58
5 The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins. Protein Expr Purif 2007 2.10
6 The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch. J Biol Chem 2009 1.39
7 Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor. J Med Chem 2010 1.33
8 Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem 2009 1.31
9 Zinc binding catalytic domain of human tankyrase 1. J Mol Biol 2008 1.09
10 Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B). Bioorg Med Chem Lett 2004 0.91
11 A secretory system for bacterial production of high-profile protein targets. Protein Sci 2011 0.87
12 Structure-based screening and design in drug discovery. Drug Discov Today 2002 0.86
13 Open-access public-private partnerships to enable drug discovery--new approaches. IDrugs 2010 0.83
14 PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol 2013 0.83
15 Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening. J Med Chem 2012 0.81
16 A software tool to accelerate design of protein constructs for recombinant expression. Protein Expr Purif 2010 0.80
17 Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem 2013 0.76
18 Backbone 1H, 13C and 15N resonance assignment of the N-terminal 24 kDa fragment of the gyrase B subunit from E. coli. J Biomol NMR 2002 0.75