A SImplified method for Segregation Analysis (SISA) to determine penetrance and expression of a genetic variant in a family.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 21309035)

Published in Hum Mutat on February 22, 2011

Authors

Pål Møller1, Neal Clark, Lovise Mæhle

Author Affiliations

1: Section for Cancer Genetics, Department of Genetics, Radiumhosptialet, Oslo University Hospital, N-0310 Oslo, Norway. Moller.pal@gmail.com

Articles by these authors

Surveillance for familial breast cancer: Differences in outcome according to BRCA mutation status. Int J Cancer (2007) 1.84

Germ-line mutations in mismatch repair genes associated with prostate cancer. Cancer Epidemiol Biomarkers Prev (2009) 1.37

Genetic epidemiology of BRCA mutations--family history detects less than 50% of the mutation carriers. Eur J Cancer (2007) 1.32

High risk for ovarian cancer in a prospective series is restricted to BRCA1/2 mutation carriers. Clin Cancer Res (2008) 0.95

Germline PTEN mutations are rare and highly penetrant. Hered Cancer Clin Pract (2006) 0.94

Survival of patients with BRCA1-associated breast cancer diagnosed in an MRI-based surveillance program. Breast Cancer Res Treat (2013) 0.90

Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer. Scand J Gastroenterol (2007) 0.89

The clinical utility of genetic testing in breast cancer kindreds: a prospective study in families without a demonstrable BRCA mutation. Breast Cancer Res Treat (2014) 0.85

CGEN--a Clinical GENetics software application. Hum Mutat (2011) 0.84

Fanconi anaemia, BRCA2 and familial considerations - follow up on a previous case report. Acta Paediatr (2010) 0.78

No sib pair concordance for breast or ovarian cancer in BRCA1 mutation carriers. Hered Cancer Clin Pract (2007) 0.78

Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. BMC Med Genet (2012) 0.76

High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series. Hered Cancer Clin Pract (2010) 0.75

High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers. Fam Cancer (2008) 0.75