Published in J Med Chem on February 16, 2011
Novel human mPGES-1 inhibitors identified through structure-based virtual screening. Bioorg Med Chem (2011) 1.05
Identification and development of mPGES-1 inhibitors: where we are at? Future Med Chem (2011) 1.04
Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis. PLoS One (2012) 0.77
E- or Z-Selective synthesis of 4-fluorovinyl-1,2,3-triazoles with fluorinated second-generation Julia-Kocienski reagents. Org Biomol Chem (2015) 0.77
Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors. ACS Med Chem Lett (2015) 0.76
Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and evaluation for antibacterial/antifungal activity. Arch Pharm (Weinheim) (2014) 0.75
Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Bioorg Med Chem Lett (2012) 0.75
Computational models for the classification of mPGES-1 inhibitors with fingerprint descriptors. Mol Divers (2017) 0.75
5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci (2007) 2.53
Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods. Chem Rev (2007) 1.81
A prospective study of laparoscopy versus minilaparotomy in the treatment of uterine myomas. J Minim Invasive Gynecol (2005) 1.48
Effects of estrogen-progestin therapy on serum levels of RANKL, osteoprotegerin, osteocalcin, leptin, and ghrelin in postmenopausal women. Menopause (2007) 1.47
Hysteroscopic transcervical endometrial resection versus thermal destruction for menorrhagia: a prospective randomized trial on satisfaction rate. Am J Obstet Gynecol (2002) 1.46
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. Hum Mol Genet (2008) 1.43
ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Proc Natl Acad Sci U S A (2008) 1.28
Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). J Med Chem (2009) 1.23
The 5-lipoxygenase promoter is regulated by DNA methylation. J Biol Chem (2001) 1.22
Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity. J Med Chem (2010) 1.18
Comparison of different theory models and basis sets in the calculation of 13C NMR chemical shifts of natural products. Magn Reson Chem (2004) 1.18
Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol (2008) 1.14
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol (2002) 1.13
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet (2011) 1.12
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci U S A (2006) 1.12
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS One (2011) 1.11
Effects of hormone replacement therapy on ocular function in postmenopause. Menopause (2003) 1.11
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1. J Pharmacol Exp Ther (2008) 1.09
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. J Nat Prod (2011) 1.08
Hysteroscopic myomectomy: a comprehensive review of surgical techniques. Hum Reprod Update (2007) 1.07
Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry. J Org Chem (2009) 1.05
Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4. J Am Chem Soc (2007) 1.05
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol (2011) 1.05
Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer: a pilot study. Gynecol Oncol (2005) 1.04
Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors. J Med Chem (2011) 1.04
Boswellic acids: biological actions and molecular targets. Curr Med Chem (2006) 1.04
Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei. Org Lett (2011) 1.04
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds. J Nat Prod (2011) 1.03
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX. J Med Chem (2012) 1.03
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. J Med Chem (2008) 1.03
Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ. J Am Chem Soc (2010) 1.01
Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. J Pharmacol Exp Ther (2008) 1.01
5-Lipoxygenase inhibitors: a review of recent developments and patents. Expert Opin Ther Pat (2010) 0.99
Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. Mol Cancer Ther (2009) 0.99
Celecoxib inhibits 5-lipoxygenase. Biochem Pharmacol (2008) 0.99
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochem Pharmacol (2009) 0.98
A prospective randomized study of laparoscopy and minilaparotomy in the management of benign adnexal masses. Hum Reprod (2004) 0.96
Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes. FASEB J (2011) 0.96
Chemistry and biology of chromatin remodeling agents: state of art and future perspectives of HDAC inhibitors. Curr Med Chem (2006) 0.95
Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach. J Med Chem (2009) 0.95
Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. Org Biomol Chem (2011) 0.95
Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors. FASEB J (2003) 0.95
Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. PLoS One (2012) 0.95
Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species. J Org Chem (2010) 0.95
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9. Apoptosis (2008) 0.94
Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. AIDS (2006) 0.93
Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod (2004) 0.93
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. Biochem Biophys Res Commun (2002) 0.93
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem (2010) 0.93
New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component. Food Funct (2011) 0.92
Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids. Biochem Pharmacol (2007) 0.92
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase. J Pharmacol Exp Ther (2011) 0.92
Hysteroscopic treatment of atypical polypoid adenomyoma diagnosed incidentally in a young infertile woman. Fertil Steril (2007) 0.92
Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1. Biochem Biophys Res Commun (2009) 0.91
Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei. J Med Chem (2011) 0.91
Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter". Org Lett (2012) 0.91
Marine sponge steroids as nuclear receptor ligands. Trends Pharmacol Sci (2012) 0.90
Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. Proc Natl Acad Sci U S A (2013) 0.90
Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide. Bioorg Med Chem (2008) 0.90
Design and synthesis of cyclopeptide analogues of the potent histone deacetylase inhibitor FR235222. ChemMedChem (2007) 0.90
Structure validation of natural products by quantum-mechanical GIAO calculations of 13C NMR chemical shifts. Chemistry (2002) 0.90
Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidism. Maturitas (2004) 0.89
Quantum mechanical calculations of NMR J coupling values in the determination of relative configuration in organic compounds. Org Lett (2004) 0.89
Extension of the J-based configuration analysis to multiple conformer equilibria: an application to sapinofuranone A. Org Lett (2002) 0.89
Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: a prospective, randomized, controlled study. Fertil Steril (2003) 0.89
Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes. J Biol Chem (2013) 0.88
Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor. J Med Chem (2011) 0.88
Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. Biochem Pharmacol (2013) 0.87
Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C. Mol Biosyst (2012) 0.87
Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide. Bioorg Med Chem (2005) 0.87
Hormonal contraception and bone metabolism: a systematic review. Contraception (2012) 0.87
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1). J Med Chem (2011) 0.87
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid. J Leukoc Biol (2003) 0.87
Molecular insights into azumamide e histone deacetylases inhibitory activity. J Am Chem Soc (2007) 0.87
Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization. Cancer Biol Ther (2011) 0.87
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. Biochim Biophys Acta (2006) 0.87
4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity. Steroids (2012) 0.87
Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo. Front Pharmacol (2011) 0.87
Modulation of tau protein fibrillization by oleocanthal. J Nat Prod (2012) 0.86
Total synthesis of azumamides A and E. Angew Chem Int Ed Engl (2006) 0.86
Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochem Pharmacol (2010) 0.86