Published in PLoS One on March 09, 2011
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nat Cell Biol (2015) 2.53
VEGF regulates local inhibitory complement proteins in the eye and kidney. J Clin Invest (2016) 1.39
Review series: The cell biology of renal filtration. J Cell Biol (2015) 1.25
Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis. Am J Physiol Renal Physiol (2015) 0.92
Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int (2015) 0.91
The role of the glomerular endothelium in albumin handling. Nat Rev Nephrol (2013) 0.90
EHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology. Circ Res (2014) 0.88
Differential expression of Vegfr-2 and its soluble form in preeclampsia. PLoS One (2012) 0.82
Eps homology domain endosomal transport proteins differentially localize to the neuromuscular junction. Skelet Muscle (2012) 0.81
Scratching the surface: actin' and other roles for the C-terminal Eps15 homology domain protein, EHD2. Histol Histopathol (2013) 0.80
PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes. Mol Biol Cell (2016) 0.79
Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. Sci Rep (2016) 0.77
Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria. J Biol Chem (2015) 0.76
The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Dev Biol (2015) 0.76
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda) (2016) 0.75
CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface. Cell Signal (2016) 0.75
Glomerular involvement in the arthrogryposis, renal dysfunction and cholestasis syndrome. Clin Kidney J (2013) 0.75
VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med (2008) 9.87
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Mol Cell (1998) 9.85
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet (2000) 7.98
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest (2003) 6.44
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res (1997) 6.24
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet (2001) 4.00
Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev (2008) 3.49
Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol (2001) 3.03
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol (2010) 2.52
Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport. Mol Biol Cell (2005) 2.40
Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest (2001) 2.36
Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development (1998) 2.31
Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. J Clin Invest (2001) 2.26
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol (2006) 2.10
Mechanisms of EHD/RME-1 protein function in endocytic transport. Traffic (2008) 1.94
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood (2006) 1.87
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Role of the VEGF--a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol (2007) 1.80
Development of the renal glomerulus: good neighbors and good fences. Development (2008) 1.79
New insights into the role of podocytes in proteinuria. Nat Rev Nephrol (2009) 1.77
Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. BMC Cell Biol (2007) 1.58
Contribution of the endothelium to the glomerular permselectivity barrier in health and disease. Nephron Physiol (2007) 1.52
The glomerular injury of preeclampsia. J Am Soc Nephrol (2007) 1.50
ATP binding regulates oligomerization and endosome association of RME-1 family proteins. J Biol Chem (2005) 1.49
The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion. J Biol Chem (2008) 1.45
Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem (2004) 1.38
EHD proteins are associated with tubular and vesicular compartments and interact with specific phospholipids. Exp Cell Res (2006) 1.34
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. J Am Soc Nephrol (2007) 1.33
EHD1 and Eps15 interact with phosphatidylinositols via their Eps15 homology domains. J Biol Chem (2007) 1.28
Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun (2010) 1.23
EH domain proteins regulate cardiac membrane protein targeting. Circ Res (2010) 1.15
Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting. J Neurosci (2010) 1.11
Update on the glomerular filtration barrier. Curr Opin Nephrol Hypertens (2009) 1.06
Blockade of platelet-derived growth factor receptor-beta pathway induces apoptosis of vascular endothelial cells and disrupts glomerular capillary formation in neonatal mice. Am J Pathol (2002) 1.05
Differential binding of the lectins Griffonia simplicifolia I and Lycopersicon esculentum to microvascular endothelium: organ-specific localization and partial glycoprotein characterization. Eur J Cell Biol (1990) 1.03
The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC Dev Biol (2010) 1.03
EHD4 and CDH23 are interacting partners in cochlear hair cells. J Biol Chem (2009) 1.00
VEGF receptor trafficking in angiogenesis. Biochem Soc Trans (2009) 0.98
Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. Genesis (2010) 0.92
The importance of cellular VEGF bioactivity in the development of glomerular disease. Nephron Exp Nephrol (2009) 0.90
Gene expression programs of mouse endothelial cells in kidney development and disease. PLoS One (2010) 0.90
Identification of proteins differentially expressed between capillary endothelial cells of hepatocellular carcinoma and normal liver in an orthotopic rat tumor model using 2-D DIGE. Proteomics (2010) 0.84
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol (2003) 3.69
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res (2002) 3.16
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res (2006) 3.12
Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab (2010) 3.05
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome. Blood (2009) 2.33
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem (2003) 2.23
Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol (2003) 2.00
Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene (2004) 1.83
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. J Cell Biol (2005) 1.73
Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res (2007) 1.70
ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem (2003) 1.70
Glomerular endothelial glycocalyx constitutes a barrier to protein permeability. J Am Soc Nephrol (2007) 1.69
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell (2006) 1.67
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity (2004) 1.65
Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. BMC Cell Biol (2007) 1.58
The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity (2004) 1.58
Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res (2007) 1.56
Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior. Cancer Res (2007) 1.51
Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade. Crit Care Med (2011) 1.48
Phosphodiesterase-5 inhibition prevents postcardiopulmonary bypass acute kidney injury in swine. Ann Thorac Surg (2011) 1.46
Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability. J Pathol (2012) 1.45
Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.40
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39
VEGF regulates local inhibitory complement proteins in the eye and kidney. J Clin Invest (2016) 1.39
Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol (2002) 1.38
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol Biol Cell (2005) 1.36
Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol (2005) 1.35
The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem (2007) 1.33
Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem (2002) 1.32
Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptide. Cancer Res (2010) 1.32
The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol (2002) 1.32
The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells. Am J Physiol Renal Physiol (2008) 1.31
Histological, molecular and functional subtypes of breast cancers. Cancer Biol Ther (2010) 1.30
TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene (2004) 1.30
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood (2012) 1.28
Mammary epithelial cell transformation: insights from cell culture and mouse models. Breast Cancer Res (2005) 1.26
The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development. Nephron Physiol (2008) 1.24
Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol Biol Cell (2004) 1.24
A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell (2007) 1.22
Negative regulation of EphA2 receptor by Cbl. Biochem Biophys Res Commun (2002) 1.21
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts. Cancer Res (2008) 1.20
CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Hum Mol Genet (2007) 1.16
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias. J Exp Med (2014) 1.16
Telomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiate. Proc Natl Acad Sci U S A (2010) 1.15
EH domain proteins regulate cardiac membrane protein targeting. Circ Res (2010) 1.15
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem (2006) 1.12
Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J (2006) 1.12
Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J (2010) 1.11
Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. J Immunol (2007) 1.09
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A (2007) 1.08
Properties and regulation of a transiently assembled ERK2.Ets-1 signaling complex. Biochemistry (2006) 1.07
An essential role of human Ada3 in p53 acetylation. J Biol Chem (2007) 1.07
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A (2010) 1.07
Shiga toxin 2 targets the murine renal collecting duct epithelium. Infect Immun (2009) 1.07
Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res (2009) 1.06
Microalbuminuria: causes and implications. Pediatr Nephrol (2011) 1.05
Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. J Biol Chem (2010) 1.05
Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med (2002) 1.05
Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function. Am J Physiol Renal Physiol (2009) 1.04
A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells. Cancer Biol Ther (2008) 1.04
Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression. J Biol Chem (2012) 1.03
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability. Cell Cycle (2012) 1.03
The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC Dev Biol (2010) 1.03
Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src. BMC Cell Biol (2009) 1.03