Published in Trials on April 01, 2011
General practice-based clinical trials in Germany - a problem analysis. Trials (2012) 0.84
Gaining information about home visits in primary care: methodological issues from a feasibility study. BMC Fam Pract (2014) 0.79
Clinical drug trials in general practice: a 10-year overview of protocols. Trials (2013) 0.77
Quantity, topics, methods and findings of randomised controlled trials published by German university departments of general practice - systematic review. Trials (2016) 0.75
Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet (2005) 6.86
A randomised controlled trial of management strategies for acute infective conjunctivitis in general practice. BMJ (2006) 4.27
Regulation--the real threat to clinical research. BMJ (2008) 3.95
Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial. Lancet (2008) 3.59
Specific barriers to the conduct of randomized trials. Clin Trials (2008) 2.68
Damage to important clinical trials by over-regulation. Clin Trials (2010) 1.94
Reducing antibiotic prescriptions for acute cough by motivating GPs to change their attitudes to communication and empowering patients: a cluster-randomized intervention study. J Antimicrob Chemother (2007) 1.91
The unintended consequences of clinical trials regulations. PLoS Med (2009) 1.91
Short report: how often do UK primary care trials face recruitment delays? Fam Pract (2007) 1.90
Survey among 78 studies showed that Lasagna's law holds in Dutch primary care research. J Clin Epidemiol (2007) 1.87
Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial. BMC Med (2010) 1.77
Clinical relevance of laboratory-reported antibiotic resistance in acute uncomplicated urinary tract infection in primary care. J Antimicrob Chemother (2006) 1.64
Five next steps for a new national program for comparative-effectiveness research. N Engl J Med (2010) 1.60
Series: The research agenda for general practice/family medicine and primary health care in Europe. Part 4. Results: specific problem solving skills. Eur J Gen Pract (2010) 1.56
Recruitment and retention in a multicentre randomised controlled trial in Bell's palsy: a case study. BMC Med Res Methodol (2007) 1.34
Effects of two guideline implementation strategies on patient outcomes in primary care: a cluster randomized controlled trial. Spine (Phila Pa 1976) (2008) 1.32
Risk analysis and risk adapted on-site monitoring in noncommercial clinical trials. Clin Trials (2009) 1.22
Improved guideline adherence to pharmacotherapy of chronic systolic heart failure in general practice--results from a cluster-randomized controlled trial of implementation of a clinical practice guideline. J Eval Clin Pract (2008) 1.20
Sensible guidelines for the conduct of large randomized trials. Clin Trials (2008) 1.07
The Clinical Trials Transformation Initiative (CTTI). Ann Ist Super Sanita (2011) 0.95
[Documentation of electronic patient records (EPRS) in German general practices: a telephone survey]. Z Arztl Fortbild Qualitatssich (2005) 0.80
Strengthen clinical trials driven by investigators, Europe research councils say. BMJ (2009) 0.78
Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med (2015) 8.61
Defibrillator implantation early after myocardial infarction. N Engl J Med (2009) 5.25
Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation (2003) 3.04
The diagnosis of urinary tract infection: a systematic review. Dtsch Arztebl Int (2010) 3.01
Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Public Health (2011) 2.83
Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS One (2010) 2.80
Absolute cardiovascular disease risk and shared decision making in primary care: a randomized controlled trial. Ann Fam Med (2008) 2.59
Prevalence of thyroid disorders in the working population of Germany: ultrasonography screening in 96,278 unselected employees. Thyroid (2004) 2.50
The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain (2012) 2.49
Rapid identification of bacteria from positive blood culture bottles by use of matrix-assisted laser desorption-ionization time of flight mass spectrometry fingerprinting. J Clin Microbiol (2010) 2.47
Pragmatic randomized trial evaluating the clinical and economic effectiveness of acupuncture for chronic low back pain. Am J Epidemiol (2006) 2.31
Acupuncture in patients with osteoarthritis of the knee or hip: a randomized, controlled trial with an additional nonrandomized arm. Arthritis Rheum (2006) 2.20
Chronic atrial fibrillation is a biatrial arrhythmia: data from catheter ablation of chronic atrial fibrillation aiming arrhythmia termination using a sequential ablation approach. Circ Arrhythm Electrophysiol (2008) 2.13
Simply no time? Barriers to GPs' participation in primary health care research. Fam Pract (2008) 2.12
The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study. BMC Health Serv Res (2012) 2.11
Urinary tract infections in adult general practice patients. Br J Gen Pract (2002) 2.10
Fundoplication versus medical management of gastroesophageal reflux disease: systematic review and meta-analysis. Surg Endosc (2013) 2.07
Health service use among patients with chronic or multiple illnesses, and frequent attenders: secondary analysis of routine primary care data from 1996 to 2006. Dtsch Arztebl Int (2012) 1.95
Reducing antibiotic prescriptions for acute cough by motivating GPs to change their attitudes to communication and empowering patients: a cluster-randomized intervention study. J Antimicrob Chemother (2007) 1.91
Antibiotic resistance of urinary pathogens in female general practice patients. Scand J Infect Dis (2005) 1.83
Noise burden and the risk of myocardial infarction. Eur Heart J (2005) 1.80
Determination of interobserver variability for identifying inducible left ventricular wall motion abnormalities during dobutamine stress magnetic resonance imaging. Eur Heart J (2006) 1.79
Comparison of two self-rating instruments for medication adherence assessment in hypertension revealed insufficient psychometric properties. J Clin Epidemiol (2009) 1.78
Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial. BMC Med (2010) 1.77
Acupuncture in patients with seasonal allergic rhinitis: a randomized trial. Ann Intern Med (2013) 1.76
Implementing an advance care planning program in German nursing homes: results of an inter-regionally controlled intervention trial. Dtsch Arztebl Int (2014) 1.72
Long-term single- and multiple-procedure outcome and predictors of success after catheter ablation for persistent atrial fibrillation. Heart Rhythm (2011) 1.71
Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study. Arch Surg (2007) 1.69
The research agenda for general practice/family medicine and primary health care in Europe. Part 3. Results: person centred care, comprehensive and holistic approach. Eur J Gen Pract (2010) 1.67
Annual distribution of ventricular tachycardias and ventricular fibrillation. Am Heart J (2003) 1.56
Elevated risk profile of women in secondary prevention of coronary artery disease: a 6-year survey of 117,913 patients. J Womens Health (Larchmt) (2009) 1.53
Series: The research agenda for general practice/family medicine and primary health care in Europe. Part 5: Needs and implications for future research and policy. Eur J Gen Pract (2010) 1.51
Resistance profiles of urinary tract infections in general practice--an observational study. BMC Urol (2012) 1.50
Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure. Eur J Heart Fail (2013) 1.47
Clinical practice of defibrillator implantation after myocardial infarction: impact of implant time: results from the PreSCD II registry. Europace (2010) 1.45
German multicenter real-world registry of stenting for superficial femoral artery disease: clinical results and predictive factors for revascularization. J Endovasc Ther (2014) 1.43
The German MultiCare-study: Patterns of multimorbidity in primary health care - protocol of a prospective cohort study. BMC Health Serv Res (2009) 1.43
Patterns of ambulatory medical care utilization in elderly patients with special reference to chronic diseases and multimorbidity--results from a claims data based observational study in Germany. BMC Geriatr (2011) 1.41
Acupuncture for patients with chronic neck pain. Pain (2006) 1.41
Intracoronary beta-brachytherapy in chronic total occlusions: a subgroup analysis from the RENO registry. Catheter Cardiovasc Interv (2003) 1.41
Influence of patient symptoms and physical findings on general practitioners' treatment of respiratory tract infections: a direct observation study. BMC Fam Pract (2005) 1.41
Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation. Intensive Care Med (2012) 1.41
Clinical outcome following combination of cutting balloon angioplasty and coronary beta-radiation for in-stent restenosis: a report from the RENO registry. J Invasive Cardiol (2003) 1.39
Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients. J Hypertens (2010) 1.39
Series: The research agenda for general practice/family medicine and primary health care in Europe. Part 6: reaction on commentaries - how to continue with the Research Agenda? Eur J Gen Pract (2011) 1.39
Job satisfaction among primary care physicians: results of a survey. Dtsch Arztebl Int (2012) 1.32
Effects of two guideline implementation strategies on patient outcomes in primary care: a cluster randomized controlled trial. Spine (Phila Pa 1976) (2008) 1.32
Out-of-hospital delays in patients with acute stroke. Ann Emerg Med (2004) 1.32
Outcome and costs of homoeopathic and conventional treatment strategies: a comparative cohort study in patients with chronic disorders. Complement Ther Med (2005) 1.31
Participation in a quality of care study and consequences for generalizability of general practice research. Fam Pract (2005) 1.29
Shock efficacy of subcutaneous implantable cardioverter-defibrillator for prevention of sudden cardiac death: initial multicenter experience. Circ Arrhythm Electrophysiol (2012) 1.26
A comparative study demonstrated that prevalence figures on multimorbidity require cautious interpretation when drawn from a single database. J Clin Epidemiol (2013) 1.23
Low back pain in primary care: costs of care and prediction of future health care utilization. Spine (Phila Pa 1976) (2010) 1.21
Acceptance and perceived barriers of implementing a guideline for managing low back in general practice. Implement Sci (2008) 1.19
Management of urinary tract infections in female general practice patients. Fam Pract (2005) 1.16
Fluorescent cardiac imaging: a novel intraoperative method for quantitative assessment of myocardial perfusion during graded coronary artery stenosis. Circulation (2007) 1.16
Utilization patterns of ambulatory medical care before and after the diagnosis of dementia in Germany--results of a case-control study. Dement Geriatr Cogn Disord (2010) 1.14
Information needs and visitors' experience of an Internet expert forum on infertility. J Med Internet Res (2005) 1.13
Immediate versus conditional treatment of uncomplicated urinary tract infection - a randomized-controlled comparative effectiveness study in general practices. BMC Infect Dis (2012) 1.12
Acupuncture in patients with allergic rhinitis: a pragmatic randomized trial. Ann Allergy Asthma Immunol (2008) 1.11
Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study. Ann Surg (2007) 1.09
Persistence of pulmonary vein isolation after robotic remote-navigated ablation for atrial fibrillation and its relation to clinical outcome. J Cardiovasc Electrophysiol (2010) 1.08
Attitudes of medical students towards general practice: Effects of gender, a general practice clerkship and a modern curriculum. GMS Z Med Ausbild (2011) 1.08
Psychometric properties of a German version of the neck pain and disability scale. Eur Spine J (2008) 1.08
Selection effects may account for better outcomes of the German Disease Management Program for type 2 diabetes. BMC Health Serv Res (2010) 1.07
Advance directives in nursing homes: prevalence, validity, significance, and nursing staff adherence. Dtsch Arztebl Int (2012) 1.05
The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. J Neurosci (2013) 1.04
A complex regional intervention to implement advance care planning in one town's nursing homes: Protocol of a controlled inter-regional study. BMC Health Serv Res (2011) 1.03
Patient characteristics and variation in treatment outcomes: which patients benefit most from acupuncture for chronic pain? Clin J Pain (2011) 1.03
Home visits - central to primary care, tradition or an obligation? A qualitative study. BMC Fam Pract (2011) 1.03
Improvement of hypertension management by structured physician education and feedback system: cluster randomized trial. Eur J Cardiovasc Prev Rehabil (2010) 1.02
Procalcitonin-guided algorithm to reduce length of antibiotic therapy in patients with severe sepsis and septic shock. BMC Infect Dis (2013) 1.01
Sex differences in presentation, course, and management of low back pain in primary care. Clin J Pain (2008) 1.00
Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J (2009) 1.00
The impact of specialist care for low back pain on health service utilization in primary care patients: a prospective cohort study. Eur J Pain (2007) 0.99
Rationale and content of psychenet: the Hamburg Network for Mental Health. Eur Arch Psychiatry Clin Neurosci (2012) 0.99
Use of procalcitonin-guided decision-making to shorten antibiotic therapy in suspected neonatal early-onset sepsis: prospective randomized intervention trial. Neonatology (2009) 0.98
Determinants of knowledge gain in evidence-based medicine short courses: an international assessment. Open Med (2010) 0.98
Age- and sex-related changes of humeral head microarchitecture: histomorphometric analysis of 60 human specimens. J Orthop Res (2010) 0.98
Is patient self-report an adequate tool for monitoring cardiovascular conditions in patients with hypercholesterolemia? J Public Health (Oxf) (2010) 0.97
Themes and methods of research presented at European General Practice Research Network conferences. Fam Pract (2010) 0.97
Depression and anxiety as major determinants of neck pain: a cross-sectional study in general practice. BMC Musculoskelet Disord (2009) 0.97
Angiotensin II-antagonist in paroxysmal atrial fibrillation (ANTIPAF) trial. Circ Arrhythm Electrophysiol (2011) 0.96
Rationale and Design of FIRE AND ICE: A multicenter randomized trial comparing efficacy and safety of pulmonary vein isolation using a cryoballoon versus radiofrequency ablation with 3D-reconstruction. J Cardiovasc Electrophysiol (2014) 0.96
Student evaluation of a primary care clerkship: quality assurance and identification of potential for improvement. BMC Med Educ (2009) 0.96
Learning core clinical skills--a survey at 3 time points during medical education. Med Teach (2007) 0.96