Highly effective gene transfection in vivo by alkylated polyethylenimine.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMC 3065804)

Published in J Drug Deliv on March 21, 2011

Authors

Jennifer A Fortune1, Tatiana I Novobrantseva, Alexander M Klibanov

Author Affiliations

1: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Articles cited by this

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A (1995) 18.16

A new solid-state reagent to iodinate proteins. I. Conditions for the efficient labeling of antiserum. Anal Biochem (1982) 6.53

Gene therapy -- promises, problems and prospects. Nature (1997) 6.02

Gene therapy death prompts review of adenovirus vector. Science (1999) 4.33

Poly(ethylenimine) and its role in gene delivery. J Control Release (1999) 3.78

Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med (2005) 2.71

The future of gene therapy. Nature (2004) 2.65

Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A (2003) 2.37

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A (2005) 2.23

Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release (2003) 2.18

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A (2002) 2.00

Non-viral gene delivery systems. Curr Opin Biotechnol (2002) 2.00

Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med (2001) 1.78

An overview of current delivery systems in cancer gene therapy. J Control Release (2004) 1.77

Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res (2009) 1.64

Characterization of commercially available and synthesized polyethylenimines for gene delivery. J Control Release (2000) 1.59

Biophysical characterization of PEI/DNA complexes. J Pharm Sci (2003) 1.44

Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. J Biotechnol (2006) 1.37

Gene delivery with low molecular weight linear polyethylenimines. J Gene Med (2005) 1.07

Influence of acyl chain length on transfection mediated by acylated PEI nanoparticles. Int J Pharm (2006) 0.98

Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library. Pharm Res (2007) 0.89

Novel chitosan-derived nanomaterials and their micelle-forming properties. J Agric Food Chem (2006) 0.87

Iodo-Gen-mediated radioiodination of nucleic acids. Anal Biochem (1988) 0.87

Effects of alkylated polyethylenimines on the formation of gold nanoplates. Langmuir (2007) 0.83

Quaternized poly(4-vinylpyridine)s as model gene delivery polycations: structure-function study by modification of side chain hydrophobicity and degree of alkylation. Bioconjug Chem (2007) 0.78

Articles by these authors

Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med (2005) 4.04

Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc Natl Acad Sci U S A (2010) 3.72

Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A (2012) 2.42

Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A (2003) 2.37

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A (2005) 2.23

Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A (2002) 2.00

Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. J Biol Chem (2012) 1.75

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol (2007) 1.68

Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res (2009) 1.64

Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm Res (2005) 1.46

Surpassing nature: rational design of sterile-surface materials. Trends Biotechnol (2005) 1.46

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Natl Acad Sci U S A (2014) 1.30

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A (2012) 1.26

Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Immunity (2002) 1.25

Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display. Chem Biol (2007) 1.23

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther (2011) 1.23

Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity (2006) 1.21

Immobilized N-alkylated polyethylenimine avidly kills bacteria by rupturing cell membranes with no resistance developed. Biotechnol Bioeng (2005) 1.19

Polymeric coatings that inactivate both influenza virus and pathogenic bacteria. Proc Natl Acad Sci U S A (2006) 1.19

Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria. Biotechnol Bioeng (2002) 1.14

Computational prediction of native protein ligand-binding and enzyme active site sequences. Proc Natl Acad Sci U S A (2005) 1.14

A potential approach for decreasing the burst effect of protein from PLGA microspheres. J Pharm Sci (2003) 1.12

Mechanistic studies on aggregation of polyethylenimine-DNA complexes and its prevention. Biotechnol Bioeng (2005) 1.12

One-step, painting-like coating procedures to make surfaces highly and permanently bactericidal. Biotechnol Prog (2006) 1.12

Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines. Biotechnol Prog (2002) 1.12

Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1. Am J Physiol Lung Cell Mol Physiol (2010) 1.10

Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine. Biotechnol Bioeng (2003) 1.09

Preparation, application and testing of permanent antibacterial and antiviral coatings. Nat Protoc (2007) 1.07

Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med (2005) 1.05

Highly L and D enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method. Proc Natl Acad Sci U S A (2008) 1.04

Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements. J Exp Med (2003) 1.02

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation. Cancer Immunol Immunother (2012) 1.01

Non-viral siRNA delivery to the lung. Adv Drug Deliv Rev (2007) 1.01

Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells. J Immunol (2003) 0.98

Nanocrystals modified with peptide nucleic acids (PNAs) for selective self-assembly and DNA detection. J Am Chem Soc (2003) 0.95

Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection. Biomaterials (2011) 0.95

BMP7 gene transfer via gold nanoparticles into stroma inhibits corneal fibrosis in vivo. PLoS One (2013) 0.92

Sequence optimization and designability of enzyme active sites. Proc Natl Acad Sci U S A (2005) 0.91

Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea. Nanomedicine (2011) 0.91

Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses. Biotechnol Lett (2007) 0.90

Specificity of a DNA-based (DNAzyme) peroxidative biocatalyst. Biotechnol Lett (2006) 0.90

Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library. Pharm Res (2007) 0.89

Hydrophobic salts markedly diminish viscosity of concentrated protein solutions. Biotechnol Bioeng (2010) 0.88

Bifunctional polymeric inhibitors of human influenza A viruses. Pharm Res (2009) 0.88

RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma. PLoS One (2012) 0.86

Optimized protocol for the large scale production of HIV pseudovirions by transient transfection of HEK293T cells with linear fully deacylated polyethylenimine. J Virol Methods (2007) 0.85

Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus. J Pharm Sci (2010) 0.85

Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials. Biomaterials (2011) 0.84

Reducing infectivity of HIV upon exposure to surfaces coated with N,N-dodecyl, methyl-polyethylenimine. Biotechnol Bioeng (2013) 0.83

Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity. Mol Ther Nucleic Acids (2013) 0.82

Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection. Proc Natl Acad Sci U S A (2012) 0.82

Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions. Biomaterials (2010) 0.82

Dual functional polyelectrolyte multilayer coatings for implants: permanent microbicidal base with controlled release of therapeutic agents. J Am Chem Soc (2010) 0.80

Drastically lowered protein adsorption on microbicidal hydrophobic/hydrophilic polyelectrolyte multilayers. Biomacromolecules (2012) 0.80

Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-β type II receptor (sTGFβRII) gene transfer. Mol Vis (2012) 0.80

Making thin polymeric materials, including fabrics, microbicidal and also water-repellent. Biotechnol Lett (2003) 0.80

Structure-activity relationship for hydrophobic salts as viscosity-lowering excipients for concentrated solutions of monoclonal antibodies. Pharm Res (2012) 0.80

Enhancement of plasmid DNA immunogenicity with linear polyethylenimine. Eur J Immunol (2012) 0.79

Practical aspects of hydrophobic polycationic bactericidal "paints". Appl Biochem Biotechnol (2008) 0.79

Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection. Expert Opin Biol Ther (2005) 0.79

Why inhaling salt water changes what we exhale. J Colloid Interface Sci (2006) 0.79

On structural damage incurred by bacteria upon exposure to hydrophobic polycationic coatings. Biotechnol Lett (2010) 0.79

Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations. Proc Natl Acad Sci U S A (2010) 0.78

Non-aqueous suspensions of antibodies are much less viscous than equally concentrated aqueous solutions. Pharm Res (2013) 0.78

Controling the rate of protein release from polyelectrolyte complexes. Biotechnol Bioeng (2003) 0.78

Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity. J Pharm Sci (2012) 0.78

Moisture-induced aggregation of lyophilized DNA and its prevention. Pharm Res (2006) 0.78

Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions. Biotechnol Bioeng (2010) 0.77

Biocidal packaging for pharmaceuticals, foods, and other perishables. Annu Rev Chem Biomol Eng (2013) 0.76

Why do some immobilized N-alkylated polyethylenimines far surpass others in inactivating influenza viruses? Biomacromolecules (2014) 0.76

Radio frequency radiation causes no nonthermal damage in enzymes and living cells. Biotechnol Prog (2010) 0.76

Co-lyophilization with D-proline greatly enhances peroxidase's stereoselectivity in a non-aqueous medium. Biotechnol Lett (2006) 0.76

Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-dodecyl,methyl-polyethylenimine. Pharm Res (2012) 0.75

How a single-point mutation in horseradish peroxidase markedly enhances enantioselectivity. J Am Chem Soc (2009) 0.75

Binding of hydrophobic hydroxamic acids enhances peroxidase's stereoselectivity in nonaqueous sulfoxidations. J Am Chem Soc (2002) 0.75

Zanamivir conjugated to poly-L-glutamine is much more active against influenza viruses in mice and ferrets than the drug itself. Pharm Res (2013) 0.75

Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants. J Pharm Sci (2013) 0.75

Removing human immunodeficiency virus (HIV) from human blood using immobilized heparin. Biotechnol Lett (2011) 0.75

An antimicrobial polycationic sand filter for water disinfection. Water Sci Technol (2011) 0.75

Antiviral and antibacterial polyurethanes of various modalities. Appl Biochem Biotechnol (2013) 0.75

Aerosol-assisted plasma deposition of hydrophobic polycations makes surfaces highly antimicrobial. Appl Biochem Biotechnol (2013) 0.75

Light-activated covalent coating of cotton with bactericidal hydrophobic polycations. Biomacromolecules (2010) 0.75

Asymmetric thiosulfinations catalyzed by bovine serum albumin and horseradish peroxidase. Biotechnol Lett (2003) 0.75

Unexpectedly enhanced stereoselectivity of peroxidase-catalyzed sulfoxidation in branched alcohols. Biotechnol Bioeng (2002) 0.75

Asymmetric sulfoxidations mediated by alpha-chymotrypsin. Biotechnol Bioeng (2002) 0.75

A method to investigate non-thermal effects of radio frequency radiation on pharmaceuticals with relevance to RFID technology. Conf Proc IEEE Eng Med Biol Soc (2006) 0.75

Drastically lowering the titer of waterborne bacteriophage PRD1 by exposure to immobilized hydrophobic polycations. Biotechnol Lett (2004) 0.75

Inactivation of bacteria by electric current in the presence of carbon nanotubes embedded within a polymeric membrane. Appl Biochem Biotechnol (2014) 0.75