Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 1917647)

Published in Br J Pharmacol on September 01, 1990

Authors

I J Reynolds1, E A Rush, E Aizenman

Author Affiliations

1: Department of Pharmacology, University of Pittsburgh, School of Medicine, PA 15261.

Articles cited by this

A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature (1986) 4.88

Ionic dependence of glutamate neurotoxicity. J Neurosci (1987) 3.01

Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev (1989) 2.82

3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. Proc Natl Acad Sci U S A (1987) 1.79

Selective modulation of NMDA responses by reduction and oxidation. Neuron (1989) 1.64

The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain. Br J Pharmacol (1987) 1.62

Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J Neurochem (1988) 1.51

Selective neuronal vulnerability: morphological and molecular characteristics. Prog Brain Res (1985) 1.43

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro. J Neurosci (1987) 1.34

Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol Pharmacol (1989) 1.26

Multiple sites for the regulation of the N-methyl-D-aspartate receptor. Mol Pharmacol (1988) 1.08

Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol Pharmacol (1989) 0.96

Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neurosci Lett (1990) 0.94

Neurochemical correlates to selective neuronal vulnerability. Prog Brain Res (1985) 0.92

Muscarinic agonists cause calcium influx and calcium mobilization in forebrain neurons in vitro. J Neurochem (1989) 0.87

Effects of dithiothreitol, a sulfhydryl reducing agent, on CA1 pyramidal cells of the guinea pig hippocampus in vitro. Brain Res (1988) 0.83

Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. Eur J Pharmacol (1990) 0.81

Dithiothreitol elicits epileptiform activity in CA1 of the guinea pig hippocampal slice. Brain Res (1987) 0.80

Articles by these authors

Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli. J Biol Chem (1989) 2.46

The nucleotide sequence and characterization of the relA gene of Escherichia coli. J Biol Chem (1988) 2.45

Overexpression of the relA gene in Escherichia coli. J Biol Chem (1991) 2.33

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood (1996) 1.98

rexB of bacteriophage lambda is an anti-cell death gene. Proc Natl Acad Sci U S A (1998) 1.95

p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. J Neurosci (2001) 1.74

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci Lett (1989) 1.46

Trapping channel block of NMDA-activated responses by amantadine and memantine. J Neurophysiol (1997) 1.46

The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. J Biol Chem (2000) 1.37

Apoptotic surface delivery of K+ channels. Cell Death Differ (2006) 1.31

NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro. J Neurochem (1997) 1.21

Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits. J Pharmacol Exp Ther (1996) 1.13

The indirect incorporation of pyrrolidone carboxylic acid into transfer ribonucleic acid. Biochim Biophys Acta (1970) 1.12

The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro. J Physiol (1993) 1.08

Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis. Hum Reprod (2007) 1.06

Preimplantation genetic diagnosis for BRCA1/2--a novel clinical experience. Prenat Diagn (2009) 1.05

Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflugers Arch (1987) 1.04

Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (1997) 1.02

Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons. Mol Pharmacol (1998) 1.01

The essentiality of decyclization of pyrrolidonecarboxylic acid prior to utilization in protein biosynthesis. Cancer Res (1971) 0.98

NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. J Neurosci (2000) 0.97

The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. J Neurosci (1988) 0.97

Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid. Leukemia (1997) 0.96

The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties. Blood (2000) 0.95

Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro. J Physiol (2000) 0.93

The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury. Neuroscience (1994) 0.92

Botulinum toxin prevents stimulus-induced backfiring produced by neostigmine in the mouse phrenic nerve-diaphragm. J Physiol (1986) 0.89

Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures. J Neurosci (2000) 0.88

Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons. Brain Res (1992) 0.87

Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science (1988) 0.87

Functional expression of muscle-type nicotinic acetylcholine receptors in rat forebrain neurons in vitro. Methods Find Exp Clin Pharmacol (2002) 0.87

Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. J Neurosci (1989) 0.87

A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience (2006) 0.87

Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate. Eur J Neurosci (1998) 0.86

Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons. Eur J Pharmacol (1997) 0.86

A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors. J Pharmacol Exp Ther (1999) 0.86

Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro. Neuron (1993) 0.85

N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci (1991) 0.85

The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site. J Neurochem (2001) 0.85

Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proc Natl Acad Sci U S A (1988) 0.84

Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J Neurosci (1992) 0.83

Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons. Neurosci Lett (1991) 0.82

Intrinsic redox properties of N-methyl-D-aspartate receptor can determine the developmental expression of excitotoxicity in rat cortical neurons in vitro. Brain Res (1997) 0.81

Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-D-aspartate receptor. Neurosci Lett (1994) 0.81

Autoradiographic localization of putative nicotinic receptors in the rat brain using 125I-neuronal bungarotoxin. J Neurosci (1991) 0.81

Subunit-specific interactions of cyanide with the N-methyl-D-aspartate receptor. J Biol Chem (1998) 0.81

Cholinergic agonist and antagonist interactions on the putative nicotinic cholinoceptor of motor neurons. Proc West Pharmacol Soc (1984) 0.80

Long-lasting modification of the N-methyl-D-aspartate receptor channel by a voltage-dependent sulfhydryl redox process. Mol Pharmacol (1993) 0.80

Inhibition by intracellular Mg(2+) of recombinant N-methyl-D-aspartate receptors expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther (2000) 0.79

SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro. Neuroscience (2012) 0.79

Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin. J Neurochem (1995) 0.79

Studies on the effects of several pentamidine analogues on the NMDA receptor. Eur J Pharmacol (1993) 0.78

Depression in family practice patients. South Med J (1980) 0.78

Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. J Neurochem (1994) 0.78

Lipid embolism to the brain after lymphography. N Engl J Med (1965) 0.78

Axonal transport of alpha-bungarotoxin binding sites in rat sciatic nerve. Brain Res (1985) 0.77

An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors. J Pharmacol Exp Ther (1998) 0.77

2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin. Proc Natl Acad Sci U S A (1991) 0.76

Role of lipid solubility in the interaction of drugs with the N-methyl-D-aspartate receptor. Synapse (1990) 0.75

TOPA quinone, a kainate-like agonist and excitotoxin is generated by a catecholaminergic cell line. J Neurosci (1995) 0.75

Neuromuscular function and organotin compounds. Neurotoxicology (1984) 0.75

Pulmonary function loss in patients on long-term anticonvulsive therapy. J Tenn Med Assoc (1988) 0.75

Selective retrograde axonal transport of free glycine in identified neurons of Aplysia. Cell Mol Neurobiol (1984) 0.75

Axonally transported alpha-bungarotoxin binding sites as a putative mechanism for motor nerve backfiring. Proc West Pharmacol Soc (1985) 0.75

Preimplantation exclusion of embryos at risk for prion diseases. Neurology (2006) 0.75

Nonenzymatic conversion of 3,4-dihydroxyphenylalanine to 2,4,5-trihydroxyphenylalanine and 2,4,5-trihydroxyphenylalanine quinone in physiological solutions. J Neurochem (1993) 0.75