Effects of the adenosine A1 receptor antagonist rolofylline on renal function in patients with acute heart failure and renal dysfunction: results from PROTECT (Placebo-Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function).

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🔗 View Article (PMID 21545947)

Published in J Am Coll Cardiol on May 10, 2011

Authors

Adriaan A Voors1, Howard C Dittrich, Barry M Massie, Paul DeLucca, George A Mansoor, Marco Metra, Gad Cotter, Beth D Weatherley, Piotr Ponikowski, John R Teerlink, John G F Cleland, Christopher M O'Connor, Michael M Givertz

Author Affiliations

1: University of Groningen, Groningen, the Netherlands.

Associated clinical trials:

PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function | NCT00354458

PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function | NCT00328692

Pharmacology of Aminophylline for Acute Kidney Injury in Neonates (PAANS) | NCT02276170

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