Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability.

PubWeight™: 1.67‹?› | Rank: Top 3%

🔗 View Article (PMID 21551173)

Published in J Neurol Neurosurg Psychiatry on June 01, 2011

Authors

Umesh Vivekananda1, Zita-Rose Manjalay, Jeban Ganesalingam, Jacqueline Simms, Christopher E Shaw, P Nigel Leigh, Martin R Turner, Ammar Al-Chalabi

Author Affiliations

1: King's College London School of Medicine, London, UK.

Articles citing this

Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol (2013) 2.52

The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol (2013) 1.61

The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS. Neurology (2015) 1.40

General health status and incidence of first-onset temporomandibular disorder: the OPPERA prospective cohort study. J Pain (2013) 1.11

Age-period-cohort analysis of trends in amyotrophic lateral sclerosis in Denmark, 1970-2009. Am J Epidemiol (2013) 0.96

Amyotrophic lateral sclerosis: update and new developments. Degener Neurol Neuromuscul Dis (2012) 0.91

Potential Environmental Factors in Amyotrophic Lateral Sclerosis. Neurol Clin (2015) 0.84

Hypothesis: higher prenatal testosterone predisposes ALS patients to improved athletic performance and manual professions. Amyotroph Lateral Scler (2011) 0.83

Psychiatric disorders prior to amyotrophic lateral sclerosis. Ann Neurol (2016) 0.77

Early-onset alopecia and amyotrophic lateral sclerosis: a cohort study. Am J Epidemiol (2013) 0.77

Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord. J Neuroendocrinol (2016) 0.76

Soma size and Cav1.3 channel expression in vulnerable and resistant motoneuron populations of the SOD1G93A mouse model of ALS. Physiol Rep (2014) 0.76

Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis. Neuroimage Clin (2015) 0.76

FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Sci Rep (2016) 0.75

The real onset of amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry (2011) 0.75

Designing an Internationally Accessible Web-Based Questionnaire to Discover Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study. JMIR Res Protoc (2015) 0.75

Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb. Amyotroph Lateral Scler Frontotemporal Degener (2016) 0.75

Articles by these authors

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science (2008) 14.09

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23

Amyotrophic lateral sclerosis. Lancet (2011) 5.86

Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. Brain (2006) 5.36

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci (2011) 5.24

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet (2003) 4.19

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature (2013) 4.03

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS. Acta Neuropathol (2011) 3.73

Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. PLoS Genet (2008) 3.66

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol (2010) 3.61

Chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiol Aging (2011) 3.27

Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study. Lancet Neurol (2012) 3.04

Two cases of sudden unexpected death in epilepsy in a GEFS+ family with an SCN1A mutation. Epilepsia (2008) 2.81

Amyotrophic lateral sclerosis. Orphanet J Rare Dis (2009) 2.76

Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2009) 2.76

Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nat Genet (2004) 2.75

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med (2012) 2.65

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57

Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat Rev Neurol (2011) 2.55

Biomarkers in amyotrophic lateral sclerosis. Lancet Neurol (2009) 2.20

Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. Neurology (2013) 2.18

An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline. Neuropathology (2011) 2.16

Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits. Behav Genet (2004) 2.14

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14

Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson's disease: record linkage studies. J Neurol Neurosurg Psychiatry (2009) 2.14

Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis? J Neurol Neurosurg Psychiatry (2012) 2.07

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03

ALSOD: the Amyotrophic Lateral Sclerosis Online Database. Amyotroph Lateral Scler (2008) 1.89

Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner. Neuroimage (2011) 1.88

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain (2008) 1.72

A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic Acids Res (2005) 1.71

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder. Eur J Hum Genet (2012) 1.71

Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics (2005) 1.68

Meta-analysis of linkage studies for Alzheimer's disease--a web resource. Neurobiol Aging (2009) 1.65

Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London. J Neurol (2006) 1.61

Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis. Brain (2011) 1.57

Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet (2013) 1.57

Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain. Sci Rep (2012) 1.54

Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain (2010) 1.51

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep (2012) 1.50

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2013) 1.49

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A (2013) 1.48

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet (2008) 1.46

ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics. Hum Mutat (2012) 1.45

What is the place of thrombolysis in acute stroke? A review of the literature and a current perspective. Clin Med (2008) 1.42

Motor neurone disease is a clinical diagnosis. Pract Neurol (2012) 1.40

Epilepsy and the subsequent risk of cerebral tumour: record linkage retrospective cohort study. J Neurol Neurosurg Psychiatry (2011) 1.40

Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses. Hum Brain Mapp (2003) 1.38

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion. Acta Neuropathol (2012) 1.36

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain. Genome Res (2011) 1.35

Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases. Amyotroph Lateral Scler (2011) 1.34

Clinical care of patients with amyotrophic lateral sclerosis. Lancet Neurol (2007) 1.30

Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q. Am J Hum Genet (2003) 1.29

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments. J Cell Biol (2003) 1.24

Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration. Brain (2010) 1.24

A common founder for amyotrophic lateral sclerosis type 8 (ALS8) in the Brazilian population. Hum Genet (2005) 1.20

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules. Hum Mol Genet (2013) 1.20

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci. PLoS One (2009) 1.19

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet (2011) 1.19

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One (2009) 1.19

Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport. Hum Mol Genet (2002) 1.16

Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials. Amyotroph Lateral Scler Other Motor Neuron Disord (2004) 1.15

RNA metabolism and the pathogenesis of motor neuron diseases. Trends Neurosci (2010) 1.15

A longitudinal study of diffusion tensor MRI in ALS. Amyotroph Lateral Scler (2007) 1.15

Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes. Biol Psychiatry (2012) 1.15

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets. Neurotherapeutics (2015) 1.15

Oculomotor dysfunction in amyotrophic lateral sclerosis: a comprehensive review. Arch Neurol (2011) 1.15

Amyotrophic lateral sclerosis as a complex genetic disease. Biochim Biophys Acta (2006) 1.13

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med (2013) 1.11