Published in Br J Pharmacol on November 01, 2011
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br J Pharmacol (2013) 0.92
Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol (2013) 0.84
KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways. Am J Physiol Lung Cell Mol Physiol (2014) 0.82
The role of potassium channel activation in celecoxib-induced analgesic action. PLoS One (2013) 0.82
Activation of peripheral KCNQ channels relieves gout pain. Pain (2015) 0.80
The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br J Pharmacol (2013) 0.79
Selective activation of vascular Kv 7.4/Kv 7.5 K(+) channels by fasudil contributes to its vasorelaxant effect. Br J Pharmacol (2016) 0.77
Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol (2013) 0.77
Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca(2+) channels. BMC Res Notes (2015) 0.77
Influence of CYP2C9 and COX-2 Genetic Polymorphisms on Clinical Efficacy of Non-Steroidal Anti-Inflammatory Drugs in Treatment of Ankylosing Spondylitis. Med Sci Monit (2017) 0.75
COX-2-selective inhibitors celecoxib and deracoxib modulate TRPV3 channels. Br J Pharmacol (2017) 0.75
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics (2005) 34.83
The SWISS-MODEL Repository and associated resources. Nucleic Acids Res (2008) 11.61
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature (1996) 9.77
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature (1996) 8.63
Guide to Receptors and Channels (GRAC), 4th Edition. Br J Pharmacol (2009) 8.07
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone. Nature (1980) 7.35
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science (1998) 7.32
Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci (2000) 4.78
M-currents and other potassium currents in bullfrog sympathetic neurones. J Physiol (1982) 4.50
Neural KCNQ (Kv7) channels. Br J Pharmacol (2009) 3.20
KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther (2001) 2.78
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci (2001) 2.52
KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci (2003) 2.40
The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels. J Clin Invest (2010) 2.16
Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current. J Neurosci (2000) 2.15
The development of COX2 inhibitors. Nat Rev Drug Discov (2003) 2.14
Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles. Mol Pharmacol (2009) 2.00
The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol (2005) 1.95
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol (2000) 1.93
Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet (2000) 1.76
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. Br J Pharmacol (2007) 1.75
Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance. J Pharmacol Exp Ther (2008) 1.73
Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Arch Intern Med (2005) 1.49
Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol (2000) 1.46
Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter. J Physiol (2010) 1.43
Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials. Am J Cardiol (2006) 1.34
Cardiovascular KCNQ (Kv7) potassium channels: physiological regulators and new targets for therapeutic intervention. Mol Pharmacol (2008) 1.28
Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception. J Neurosci (2008) 1.28
Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol (2001) 1.23
Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opin Investig Drugs (2008) 1.15
Novel role of KCNQ2/3 channels in regulating neuronal cell viability. Cell Death Differ (2010) 0.89
A retrospective review of the effect of COX-2 inhibitors on blood pressure change. Am J Ther (2003) 0.85
Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. Neuropharmacology (2007) 0.79
An ion channel hypothesis to explain divergent cardiovascular safety of cyclooxygenase-2 inhibitors: the answer to a hotly debated puzzle? Mol Pharmacol (2009) 0.78
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
Prevalence of specific language impairment in kindergarten children. J Speech Lang Hear Res (1997) 6.37
Histone-like TAFs within the PCAF histone acetylase complex. Cell (1998) 5.26
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet (2001) 4.97
Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev (2001) 4.91
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature (1998) 4.47
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07
Crystal structure of four-stranded Oxytricha telomeric DNA. Nature (1992) 3.96
Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat Struct Biol (1996) 3.91
Effectiveness of community health workers in the care of persons with diabetes. Diabet Med (2006) 3.66
PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat Genet (1997) 3.58
A presynaptic inositol-5-phosphatase. Nature (1996) 3.54
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell (1999) 3.47
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell (2000) 3.44
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. J Neurosci (2000) 3.44
State estimates of Medicaid expenditures attributable to cigarette smoking, fiscal year 1993. Public Health Rep (1998) 3.41
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell (1998) 3.40
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron (1999) 3.33
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
Susceptibility testing of Cryptococcus neoformans: a microdilution technique. J Clin Microbiol (1992) 3.12
A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus. J Virol (1997) 3.10
Real time detection of DNA.RNA hybridization in living cells. Proc Natl Acad Sci U S A (1998) 3.10
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Nat Genet (1995) 3.05
Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology (1993) 3.00
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis. Proc Natl Acad Sci U S A (2006) 2.98
Human magnetic resonance imaging at 8 T. NMR Biomed (1998) 2.96
ORegAnno: an open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation. Bioinformatics (2006) 2.93
Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol (1998) 2.91
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med (2016) 2.89
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A (1998) 2.88
Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci (2001) 2.84
Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet (2000) 2.82
The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J Immunol (2000) 2.76
cisRED: a database system for genome-scale computational discovery of regulatory elements. Nucleic Acids Res (2006) 2.75
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71
An agent cleaving glucose-derived protein crosslinks in vitro and in vivo. Nature (1996) 2.71
New variants of a method of MRI scale standardization. IEEE Trans Med Imaging (2000) 2.69
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol (1999) 2.68
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem Biol (1998) 2.64
Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol (1999) 2.61
Postsynaptic membrane fusion and long-term potentiation. Science (1998) 2.59
Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain. J Bacteriol (2001) 2.59
Complete genome sequence of the shrimp white spot bacilliform virus. J Virol (2001) 2.58
Type I interferon-mediated stimulation of T cells by CpG DNA. J Exp Med (1998) 2.58
Cholesterol, coronary heart disease, and stroke in the Asia Pacific region. Int J Epidemiol (2003) 2.57
A system for the diagnosis of specific language impairment in kindergarten children. J Speech Hear Res (1996) 2.52
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron (2001) 2.52
Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005. J Virol (2006) 2.47
Messenger plasticity in primary sensory neurons following axotomy and its functional implications. Trends Neurosci (1994) 2.44
Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots. Am J Hum Genet (1999) 2.42
Large-scale psychological differences within China explained by rice versus wheat agriculture. Science (2014) 2.42
Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus. Nature (1998) 2.41
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nat Neurosci (1999) 2.40
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2. Mol Cell Biol (1998) 2.39
The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care (2003) 2.36
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? EMBO J (1998) 2.31
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A (1994) 2.29
Long-term non-pharmacological weight loss interventions for adults with prediabetes. Cochrane Database Syst Rev (2005) 2.26
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature (2001) 2.21
Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut (2005) 2.20
Multivariate matching and bias reduction in the surgical outcomes study. Med Care (2001) 2.19
State estimates of total medical expenditures attributable to cigarette smoking, 1993. Public Health Rep (1998) 2.18
Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem (1995) 2.17
Long-term non-pharmacologic weight loss interventions for adults with type 2 diabetes. Cochrane Database Syst Rev (2005) 2.17
In vivo transduction with shiga toxin 1-encoding phage. Infect Immun (1998) 2.16
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release (2001) 2.15
Components of the Arabidopsis C-repeat/dehydration-responsive element binding factor cold-response pathway are conserved in Brassica napus and other plant species. Plant Physiol (2001) 2.14
The use of Medpor coated tear drainage tube in conjunctivodacryocystorhinostomy. Eye (Lond) (2007) 2.13
Outdoor activity and myopia in Singapore teenage children. Br J Ophthalmol (2009) 2.13
Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol (1999) 2.12
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood (2000) 2.12
Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.11
Pretransplant IgG reactivity to apoptotic cells correlates with late kidney allograft loss. Am J Transplant (2014) 2.09
Identification of the activating region of catabolite gene activator protein (CAP): isolation and characterization of mutants of CAP specifically defective in transcription activation. Proc Natl Acad Sci U S A (1993) 2.08
PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int (2006) 2.05
Terahertz magnetic response from artificial materials. Science (2004) 2.05
The roaming atom: straying from the reaction path in formaldehyde decomposition. Science (2004) 2.02
PharmGED: pharmacogenetic effect database. Clin Pharmacol Ther (2007) 2.02
The challenges of genome sequence annotation or "the devil is in the details". Nat Biotechnol (1997) 2.01
Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8. J Natl Cancer Inst Monogr (1998) 2.01
Associations of IL6 polymorphisms with lung function decline and COPD. Thorax (2009) 2.00
Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol (1998) 2.00
Severe diffuse non-scarring hair loss in systemic lupus erythematosus - clinical and histopathological analysis of four cases. J Eur Acad Dermatol Venereol (2011) 1.99
Colour tuning in human visual cortex measured with functional magnetic resonance imaging. Nature (1997) 1.98
Identification of differentially expressed genes in human prostate cancer using subtraction and microarray. Cancer Res (2000) 1.98
Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science (1998) 1.97
Genotyping of Toxoplasma gondii by multilocus PCR-RFLP markers: a high resolution and simple method for identification of parasites. Int J Parasitol (2006) 1.97
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res (2000) 1.96
Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China. Clin Microbiol Infect (2008) 1.95
Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15. Infect Immun (2000) 1.94
Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src. Mol Cell Biol (2001) 1.91
Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification. Neuron (1999) 1.90
The gene for nucleoside diphosphate kinase functions as a mutator gene in Escherichia coli. J Mol Biol (1995) 1.90
An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve. Invest Ophthalmol Vis Sci (2000) 1.88
Regulation of Pax6 expression is conserved between mice and flies. Development (1999) 1.87
A precision measurement of the mass of the top quark. Nature (2004) 1.87