Published in BMC Biotechnol on May 12, 2011
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors. Cell (2004) 3.82
S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun (2004) 3.38
Structure, function and evolution of CpG island promoters. Cell Mol Life Sci (2003) 3.09
Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med (2004) 2.35
The gateway to transcription: identifying, characterizing and understanding promoters in the eukaryotic genome. Cell Mol Life Sci (2007) 2.20
Industrialization of mAb production technology: the bioprocessing industry at a crossroads. MAbs (2009) 2.03
Expression systems for therapeutic glycoprotein production. Curr Opin Biotechnol (2009) 1.66
25 years of recombinant proteins from reactor-grown cells - where do we go from here? Biotechnol Adv (2009) 1.47
Structural and functional analysis of a growth-regulated gene, the human calcyclin. J Biol Chem (1987) 1.36
The cold-shock response in cultured mammalian cells: harnessing the response for the improvement of recombinant protein production. Biotechnol Bioeng (2006) 1.33
S100A6 - new facts and features. Biochem Biophys Res Commun (2009) 1.31
Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells. Biotechnol Bioeng (2003) 1.26
Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells. Biotechnol Bioeng (1999) 1.26
Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene. Gene (1997) 1.25
RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. Hum Mol Genet (1995) 1.18
High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene. Biotechnol Prog (2004) 1.16
Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs. RNA (2009) 1.13
A comparative study of different vector designs for the mammalian expression of recombinant IgG antibodies. J Immunol Methods (2006) 1.12
Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. Genome Res (2003) 1.10
Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression. Bioessays (2010) 1.10
Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling. Biotechnol Bioeng (2004) 1.09
Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. Protein Expr Purif (2004) 1.06
Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells. J Biotechnol (2004) 1.03
Computational analyses of eukaryotic promoters. BMC Bioinformatics (2007) 0.99
Enhancement of RNA synthesis by promoter duplication in tombusviruses. Virology (2003) 0.97
Higher expression of Fab antibody fragments in a CHO cell line at reduced temperature. Biotechnol Bioeng (2003) 0.94
Adaptation of Chinese hamster ovary cells to low culture temperature: cell growth and recombinant protein production. J Biotechnol (2005) 0.91
Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells. Biotechnol J (2008) 0.90
Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha. J Biol Chem (2008) 0.90
Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: clonal variation. Biotechnol Prog (2004) 0.89
IRSS: a web-based tool for automatic layout and analysis of IRES secondary structure prediction and searching system in silico. BMC Bioinformatics (2009) 0.86
High-level recombinant protein production in CHO cells using an adenoviral vector and the cumate gene-switch. Biotechnol Prog (2007) 0.85
Calcyclin (S100A6) expression is stimulated by agents evoking oxidative stress via the antioxidant response element. Biochim Biophys Acta (2004) 0.83
Involvement of NF-kappaB in the regulation of S100A6 gene expression in human hepatoblastoma cell line HepG2. Biochem Biophys Res Commun (2003) 0.81
Detailed understanding of enhanced specific productivity in Chinese hamster ovary cells at low culture temperature. J Biosci Bioeng (2010) 0.80
Evaluation of a genomics platform for cross-species transcriptome analysis of recombinant CHO cells. Biotechnol J (2006) 0.80
High level expression of proteins using sequences from the ferritin heavy chain gene locus. J Biotechnol (2006) 0.79
Characterization of the murine Dfna5 promoter and regulatory regions. Gene (2008) 0.77
Duplication of Stat5-binding sites within the beta-lactoglobulin promoter compromises transcription in vivo. Biochimie (2005) 0.76
Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer (2011) 1.09
SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. Nucleic Acids Res (2005) 1.08
Chinese hamster genome sequenced from sorted chromosomes. Nat Biotechnol (2013) 1.07
Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. Protein Expr Purif (2004) 1.06
A two-step strategy for neuronal differentiation in vitro of human dental follicle cells. Differentiation (2009) 1.06
Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling. Biochem J (2009) 1.03
Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures. FASEB J (2007) 0.97
Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation. J Leukoc Biol (2007) 0.97
Structure and basal transcription complex of RNA polymerase II core promoters in the mammalian genome: an overview. Mol Biotechnol (2010) 0.94
Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock (2007) 0.93
Dynamic mRNA and miRNA profiling of CHO-K1 suspension cell cultures. Biotechnol J (2011) 0.89
Baculovirus for eukaryotic protein display. Curr Gene Ther (2010) 0.89
Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins. Biotechnol J (2014) 0.86
Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Mol Pharmacol (2002) 0.85
Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response. PLoS Negl Trop Dis (2012) 0.83
Exploiting nucleotide composition to engineer promoters. PLoS One (2011) 0.82
Impact of maintenance immunosuppressive regimens--balance between graft protective suppression of immune functions and a near physiological immune response. Transpl Int (2011) 0.82
A study on the temperature dependency and time course of the cold capture antibody secretion assay. J Biotechnol (2009) 0.82
Altering the surface properties of baculovirus Autographa californica NPV by insertional mutagenesis of the envelope protein gp64. Eur J Biochem (2002) 0.82
Improved display of synthetic IgG-binding domains on the baculovirus surface. Technol Cancer Res Treat (2004) 0.82
Identification of CHO endogenous gene regulatory elements. Mol Biotechnol (2010) 0.82
Tnao38, high five and Sf9--evaluation of host-virus interactions in three different insect cell lines: baculovirus production and recombinant protein expression. Biotechnol Lett (2013) 0.81
ATG induction therapy: long-term effects on Th1 but not on Th2 responses. Transpl Int (2005) 0.81
Evaluation of a genomics platform for cross-species transcriptome analysis of recombinant CHO cells. Biotechnol J (2006) 0.80
Generation of recombinant influenza virus using baculovirus delivery vector. J Virol Methods (2003) 0.80
Advances in nanopatterned and nanostructured supported lipid membranes and their applications. Biotechnol Genet Eng Rev (2010) 0.79
Evaluation of the influenza A replicon for transient expression of recombinant proteins in mammalian cells. PLoS One (2010) 0.78
Identification of CHO endogenous promoter elements based on a genomic library approach. Mol Biotechnol (2008) 0.78
Optimizing the transient transfection process of HEK-293 suspension cells for protein production by nucleotide ratio monitoring. Cytotechnology (2013) 0.78
Transcriptional profiling of phenotypically different Epo-Fc expressing CHO clones by cross-species microarray analysis. Biotechnol J (2008) 0.78
Establishment of a strategy for the rapid generation of a monoclonal antibody against the human protein SNEV (hNMP200) by flow-cytometric cell sorting. J Immunol Methods (2005) 0.78
Fluorescence dye-based detection of mAb aggregates in CHO culture supernatants. Anal Bioanal Chem (2015) 0.77
Gene expression of nestin, collagen type I and type III in human dental follicle cells after cultivation in serum-free medium. Oral Maxillofac Surg (2008) 0.77
Creation of baculovirus display libraries. Cold Spring Harb Protoc (2010) 0.77
Intracellular nucleotide pools and ratios as tools for monitoring dedifferentiation of primary porcine hepatocytes in culture. Cytotechnology (2006) 0.76
How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnol J (2012) 0.76
Baculovirus-based display and gene delivery systems. Cold Spring Harb Protoc (2010) 0.76
Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation. Appl Microbiol Biotechnol (2014) 0.76
On-line detection of microbial contaminations in animal cell reactor cultures using an electronic nose device. Cytotechnology (2005) 0.75
Artificially designed promoters: understanding the role of spatial features and canonical binding sites in transcription. Bioeng Bugs (2012) 0.75
Whole genome sequencing improves estimation of nuclear DNA content of Chinese hamster ovary cells. Cytometry A (2013) 0.75
Improvement of the energy metabolism of recombinant CHO cells by cell sorting for reduced mitochondrial membrane potential. J Biotechnol (2007) 0.75
Liver-specific physiology of immortal, functionally differentiated hepatocytes and of deficient hepatocyte-like variants. In Vitro Cell Dev Biol Anim (2005) 0.75
Immunoelectron microscopy analysis of recombinant baculovirus display viruses. Cold Spring Harb Protoc (2010) 0.75
Monitoring baculovirus-mediated efficiency of gene delivery. Cold Spring Harb Protoc (2010) 0.75
Immunofluorescence analysis of baculovirus-displayed viral proteins on infected insect cells. Cold Spring Harb Protoc (2010) 0.75
Determination of recombinant baculovirus display viral titer. Cold Spring Harb Protoc (2010) 0.75
TGF-beta stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs). Neurosci Lett (2010) 0.75
Impact of gastroesophageal reflux disease symptoms on the quality of life in pregnant women: a prospective study. Eur J Gastroenterol Hepatol (2017) 0.75