Silencing hyperoxia-induced C/EBPα in neonatal mice improves lung architecture via enhanced proliferation of alveolar epithelial cells.

PubWeight™: 0.81‹?›

🔗 View Article (PMC 3154632)

Published in Am J Physiol Lung Cell Mol Physiol on May 13, 2011

Authors

Guang Yang1, Maurice D Hinson, Jessica E Bordner, Qing S Lin, Amal P Fernando, Ping La, Clyde J Wright, Phyllis A Dennery

Author Affiliations

1: Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Articles cited by this

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet (2003) 11.01

C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell (2001) 2.97

Functional and pathological effects of prolonged hyperoxia in neonatal mice. Am J Physiol (1998) 2.67

CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol (1997) 2.44

Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2006) 1.71

The radial alveolar count method of Emery and Mithal: a reappraisal 1--postnatal lung growth. Thorax (1982) 1.69

C/EBPalpha is required for lung maturation at birth. Development (2006) 1.65

The postnatal growth of the rat lung. II. Autoradiography. Anat Rec (1974) 1.60

Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol (2006) 1.58

The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol (2001) 1.41

The post-translational modifications of proliferating cell nuclear antigen: acetylation, not phosphorylation, plays an important role in the regulation of its function. J Biol Chem (2004) 1.39

Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia. J Clin Invest (2004) 1.35

C/EBP transcription factors in the lung epithelium. Am J Physiol Lung Cell Mol Physiol (2003) 1.31

The radial alveolar count method of Emery and Mithal: a reappraisal 2--intrauterine and early postnatal lung growth. Thorax (1982) 1.22

Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol (2006) 1.21

Key developmental regulators change during hyperoxia-induced injury and recovery in adult mouse lung. J Cell Biochem (2007) 1.19

Oxygen toxicity in the newborn. The effect of prolonged 100 per cent O2 exposure on the lungs of newborn mice. Lab Invest (1975) 1.13

Chorioamnionitis, postnatal factors and proinflammatory response in the pathogenetic sequence of bronchopulmonary dysplasia. Neonatology (2009) 1.12

knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology (2006) 1.09

Application of proteomic marker ensembles to subcellular organelle identification. Mol Cell Proteomics (2009) 1.00

C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia. Am J Physiol Lung Cell Mol Physiol (2009) 0.97

Maturational differences in hyperoxic AP-1 activation in rat lung. Am J Physiol Lung Cell Mol Physiol (2000) 0.92

HO-1 expression in type II pneumocytes after transpulmonary gene delivery. Am J Physiol Lung Cell Mol Physiol (2000) 0.86

Regulation of surfactant protein gene expression by hyperoxia in the lung. Antioxid Redox Signal (2004) 0.83

Articles by these authors

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med (2011) 3.58

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem (2007) 2.08

Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia. J Clin Invest (2004) 1.35

Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem (2003) 1.25

A National Agenda for America's Children and Adolescents in 2008: recommendations from the 15th Annual Public Policy Plenary Symposium, annual meeting of the Pediatric Academic Societies, May 3, 2008. Pediatrics (2008) 1.19

Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochem Biophys Res Commun (2003) 1.18

Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction. J Am Soc Nephrol (2006) 1.13

Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radic Biol Med (2004) 1.12

Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Am J Respir Crit Care Med (2007) 1.07

Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress. Free Radic Biol Med (2007) 0.92

Interaction between heme oxygenase-1 and -2 proteins. J Biol Chem (2003) 0.91

Manipulation of gene expression by oxygen: a primer from bedside to bench. Pediatr Res (2009) 0.90

Molecular determinants of lung development. Ann Am Thorac Soc (2013) 0.89

Apigenin decreases hemin-mediated heme oxygenase-1 induction. Free Radic Biol Med (2005) 0.88

Nuclear factor-κB (NF-κB) inhibitory protein IκBβ determines apoptotic cell death following exposure to oxidative stress. J Biol Chem (2012) 0.88

Hyperoxia-induced NF-kappaB activation occurs via a maturationally sensitive atypical pathway. Am J Physiol Lung Cell Mol Physiol (2008) 0.87

NO inhibits hyperoxia-induced NF-κB activation in neonatal pulmonary microvascular endothelial cells. Pediatr Res (2010) 0.87

Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition. J Biol Chem (2009) 0.86

Endothelial protection by pentaerithrityl trinitrate: bilirubin and carbon monoxide as possible mediators. Exp Biol Med (Maywood) (2003) 0.85

The NF-κB inhibitory proteins IκBα and IκBβ mediate disparate responses to inflammation in fetal pulmonary endothelial cells. J Immunol (2013) 0.85

Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lung. Pediatr Res (2009) 0.85

Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: role of β-catenin/hnRNPK signaling. Redox Biol (2013) 0.84

Heme oxygenase-1 modulates fetal growth in the rat. Lab Invest (2002) 0.84

Disrupted postnatal lung development in heme oxygenase-1 deficient mice. Respir Res (2010) 0.83

Oxidative stress and inflammation modulate Rev-erbα signaling in the neonatal lung and affect circadian rhythmicity. Antioxid Redox Signal (2014) 0.83

Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate. Biochem Biophys Res Commun (2002) 0.83

Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver Int (2003) 0.82

IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury. Am J Respir Cell Mol Biol (2014) 0.82

Genomic medicine and lung diseases. Am J Respir Crit Care Med (2012) 0.82

trans-Arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculature. Free Radic Biol Med (2007) 0.81

Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism. J Biol Chem (2013) 0.79

Inhaled NO and markers of oxidant injury in infants with respiratory failure. J Perinatol (2005) 0.78

Gestational pattern of heme oxygenase expression in the rat. Pediatr Res (2003) 0.78

Effect of glutathione on lung activator protein-1 activation and heme oxygenase-1 induction in the immature rat. Pediatr Res (2002) 0.77

Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NFx03BA;B-Dependent Mechanism. J Innate Immun (2016) 0.76

The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med (2016) 0.76

Neonatal blue-light phototherapy could increase the risk of dysplastic nevus development. Pediatrics (2007) 0.75

Thin catheter surfactant administration during spontaneous breathing in very low birth weight infants is associated with reduced need for mechanical ventilation. J Pediatr (2013) 0.75

Predicting neonatal brain injury: are we there yet? Arch Pediatr Adolesc Med (2003) 0.75

Lessons from Goldilocks: maternal weight gain and neurocognitive outcomes of ELGAN. J Pediatr (2017) 0.75

More is not always better, at least when it comes to oxygen saturation target goals. J Pediatr (2016) 0.75

Introduction to the special issue on translational research involving oxidative stress. Free Radic Biol Med (2011) 0.75

Blunted response: smoke, illicit substances, and how babies breathe. J Pediatr (2016) 0.75

Oxygen saturation targets: The wrinkle in the pulse oximeter calibration software provides another wrinkle. J Pediatr (2017) 0.75

Too salty: biochemical markers to validate maternal concern of breastmilk supply. J Pediatr (2017) 0.75

Is more oxygen better for our smallest babies, or maybe just our smallest babies? J Pediatr (2017) 0.75

Working backwards: Can variations in neonatal outcomes help identify best practice? J Pediatr (2016) 0.75

BPD dodges multiple bullets. J Pediatr (2016) 0.75

Is preventing BPD the target, or should we strive for something else? J Pediatr (2017) 0.75

Optimizing NAS therapy - shorter stays for a growing population of babies. J Pediatr (2016) 0.75