Published in Genet Epidemiol on May 18, 2011
Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet (2013) 3.65
MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS. PLoS One (2012) 2.56
Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet (2013) 1.70
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet (2013) 1.47
A PheWAS approach in studying HLA-DRB1*1501. Genes Immun (2013) 1.42
Genetic architecture of cancer and other complex diseases: lessons learned and future directions. Carcinogenesis (2011) 1.39
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet (2011) 1.35
Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet (2013) 1.23
Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank. J Biomed Semantics (2012) 1.20
Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View. BioData Min (2012) 1.17
Secondary use of clinical data: the Vanderbilt approach. J Biomed Inform (2014) 1.12
Returning pleiotropic results from genetic testing to patients and research participants. JAMA (2014) 1.10
Toward personalizing treatment for depression: predicting diagnosis and severity. J Am Med Inform Assoc (2014) 1.08
Visualizing genomic information across chromosomes with PhenoGram. BioData Min (2013) 1.08
Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Front Genet (2014) 1.06
The challenges, advantages and future of phenome-wide association studies. Immunology (2014) 1.04
Accuracy of administratively-assigned ancestry for diverse populations in an electronic medical record-linked biobank. PLoS One (2014) 0.99
Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics. PLoS Comput Biol (2013) 0.98
Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank. Pac Symp Biocomput (2014) 0.98
Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Pac Symp Biocomput (2013) 0.93
Unravelling the human genome-phenome relationship using phenome-wide association studies. Nat Rev Genet (2016) 0.92
Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Front Genet (2014) 0.92
Mining the human phenome using semantic web technologies: a case study for Type 2 Diabetes. AMIA Annu Symp Proc (2012) 0.92
Phenome based analysis as a means for discovering context dependent clinical reference ranges. AMIA Annu Symp Proc (2012) 0.90
Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery. Curr Genet Med Rep (2015) 0.90
Enabling genomic-phenomic association discovery without sacrificing anonymity. PLoS One (2013) 0.89
The role of phenotype in gene discovery in the whole genome sequencing era. Hum Genet (2012) 0.89
strum: an R package for structural modeling of latent variables for general pedigrees. BMC Genet (2015) 0.88
Application of clinical text data for phenome-wide association studies (PheWASs). Bioinformatics (2015) 0.87
Temporal phenome analysis of a large electronic health record cohort enables identification of hospital-acquired complications. J Am Med Inform Assoc (2013) 0.87
Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study. PLoS Genet (2014) 0.87
Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circ Res (2014) 0.84
Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open Forum Infect Dis (2015) 0.83
Statin pharmacogenomics: pursuing biomarkers for predicting clinical outcomes. Discov Med (2013) 0.83
Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey. Thromb Haemost (2012) 0.83
Phenome-Wide Association Studies as a Tool to Advance Precision Medicine. Annu Rev Genomics Hum Genet (2016) 0.83
Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies. BioData Min (2014) 0.80
Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach. J Transl Med (2015) 0.78
Phenotype Information Retrieval for Existing GWAS Studies. AMIA Jt Summits Transl Sci Proc (2013) 0.78
A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes. BMC Genet (2014) 0.77
Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry. BioData Min (2015) 0.77
KNOWLEDGE DRIVEN BINNING AND PHEWAS ANALYSIS IN MARSHFIELD PERSONALIZED MEDICINE RESEARCH PROJECT USING BIOBIN. Pac Symp Biocomput (2016) 0.77
This I believe: gaining new insights through integrating "old" data. Front Genet (2012) 0.77
Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders. Psychiatr Genet (2014) 0.76
Clinical neurogenetics: stroke. Neurol Clin (2013) 0.75
Clinically relevant pharmacogenomic testing in pediatric practice. Clin Pediatr (Phila) (2014) 0.75
DermO; an ontology for the description of dermatologic disease. J Biomed Semantics (2016) 0.75
Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Pharmacogenet Genomics (2017) 0.75
Contrasting Association Results between Existing PheWAS Phenotype Definition Methods and Five Validated Electronic Phenotypes. AMIA Annu Symp Proc (2015) 0.75
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay Drug Dev Technol (2017) 0.75
[Pharmacogenomic Biomarkers for the Prediction of Statin Efficacy and Safety]. G Ital Arterioscler (2013) 0.75
Evidence for extensive pleiotropy among pharmacogenes. Pharmacogenomics (2016) 0.75
Detecting Gene-Gene Interactions Associated with Multiple Complex Traits with U-Statistics. Curr Genomics (2016) 0.75
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol (1989) 37.83
The Cardiovascular Health Study: design and rationale. Ann Epidemiol (1991) 27.24
Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group. Control Clin Trials (1998) 20.39
The NCBI dbGaP database of genotypes and phenotypes. Nat Genet (2007) 17.93
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol (2000) 13.17
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther (2008) 11.67
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
The Strong Heart Study. A study of cardiovascular disease in American Indians: design and methods. Am J Epidemiol (1990) 4.89
Recruitment in the Coronary Artery Disease Risk Development in Young Adults (Cardia) Study. Control Clin Trials (1987) 4.05
Probing genetic overlap among complex human phenotypes. Proc Natl Acad Sci U S A (2007) 3.79
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
Consent for genetic research in a general population: the NHANES experience. Genet Med (2003) 2.77
Methods for handling multiple testing. Adv Genet (2008) 2.67
Phenomics: the systematic study of phenotypes on a genome-wide scale. Neuroscience (2009) 2.38
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A (2009) 1.81
The search for genenotype/phenotype associations and the phenome scan. Paediatr Perinat Epidemiol (2005) 1.38
Phenomics: expanding the role of clinical evaluation in genomic studies. J Investig Med (2010) 1.10
A gene map of the human genome. Science (1996) 14.32
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol (2000) 13.17
A physical map of 30,000 human genes. Science (1998) 12.43
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA (1999) 11.23
Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions. J Mol Biol (1997) 10.38
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell (1988) 7.50
Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. N Engl J Med (1998) 7.12
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med (1999) 6.92
Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol (1997) 6.80
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet (2001) 5.80
Periodontal disease and cardiovascular disease. J Periodontol (1996) 5.78
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell (1987) 5.57
Regulation of PTEN transcription by p53. Mol Cell (2001) 5.44
Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. The Atherosclerosis Risk in Communities Study Investigators. N Engl J Med (1993) 5.14
Circulating activated endothelial cells in sickle cell anemia. N Engl J Med (1997) 5.13
Improved recognition of native-like protein structures using a combination of sequence-dependent and sequence-independent features of proteins. Proteins (1999) 4.86
Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc (1999) 4.84
A combined linkage-physical map of the human genome. Am J Hum Genet (2004) 4.60
Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol (2000) 4.46
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med (1999) 4.44
Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation (2001) 4.21
Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. N Engl J Med (1990) 4.10
Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study. Osteoporos Int (2012) 4.09
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet (1999) 4.07
Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther (2012) 4.05
Proximal impact of two first-grade preventive interventions on the early risk behaviors for later substance abuse, depression, and antisocial behavior. Am J Community Psychol (1999) 3.98
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev (2001) 3.43
Collection of genomic DNA from adults in epidemiological studies by buccal cytobrush and mouthwash. Cancer Epidemiol Biomarkers Prev (2001) 3.40
Control of pollen tube tip growth by a Rop GTPase-dependent pathway that leads to tip-localized calcium influx. Plant Cell (1999) 3.32
Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. N Engl J Med (1990) 3.29
Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis: three years of blinded therapy followed by one year of open therapy. Am J Med (1993) 3.23
Understanding the clinical dilemmas that shape medical students' ethical development: questionnaire survey and focus group study. BMJ (2001) 3.23
NHLBI Family Heart Study: objectives and design. Am J Epidemiol (1996) 3.21
Arterial stiffness and the development of hypertension. The ARIC study. Hypertension (1999) 3.18
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene (2006) 3.18
Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science (1984) 3.17
Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clin Pharmacol Ther (2012) 3.16
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med (1999) 3.10
Tannins and human health: a review. Crit Rev Food Sci Nutr (1998) 3.03
A controlled trial of antidepressants in patients with Parkinson disease and depression. Neurology (2008) 2.97
The action of proteolytic enzymes on N,N-dimethyl proteins. Basis for a microassay for proteolytic enzymes. J Biol Chem (1969) 2.94
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity (2000) 2.93
Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke (1995) 2.86
Evidence of an X-linked or recessive genetic component to prostate cancer risk. Nat Med (1995) 2.83
Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. Hum Mol Genet (1994) 2.83
Plasma triglyceride level and mortality from coronary heart disease. N Engl J Med (1993) 2.80
Echocardiographic and anatomical correlations in fetal congenital heart disease. Br Heart J (1984) 2.79
Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Investigators. Stroke (1993) 2.74
Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study. Circulation (1980) 2.72
Agreement between interview information and physician records on history of menopausal estrogen use. Am J Epidemiol (1990) 2.71
Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol Cell Biol (2001) 2.64
A candidate gene approach to searching for low-penetrance breast and prostate cancer genes. Nat Rev Cancer (2005) 2.62
Circumcision and human papillomavirus infection in men: a site-specific comparison. J Infect Dis (2008) 2.58
T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect Immun (1995) 2.57
Sleep patterns and total mortality: a 12-year follow-up study in Japan. J Epidemiol (2000) 2.49
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol (2000) 2.49
Parental modeling and parenting behavior effects on offspring alcohol and cigarette use. A growth curve analysis. J Subst Abuse (2000) 2.44
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci U S A (2001) 2.42
Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J (1995) 2.41
Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study. J Thromb Haemost (2007) 2.40
Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med (1998) 2.40
Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res (2000) 2.38
Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J Biol Chem (2000) 2.37
Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther (2011) 2.36
The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol (2001) 2.32
Estimating evaporation: a technique adaptable to remote sensing. Science (1975) 2.31
The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study. Neuroepidemiology (1997) 2.31
NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network. Ann Epidemiol (2000) 2.28
Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study. Osteoporos Int (2008) 2.27
Passive smoking and lung cancer. Lancet (1983) 2.27
Animal fat consumption and prostate cancer: a prospective study in Hawaii. Epidemiology (1994) 2.26
Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol (2001) 2.20
B-mode-detected carotid artery plaque in a general population. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke (1994) 2.19
Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol (1998) 2.19
The looming epidemic of diabetes-associated tuberculosis: learning lessons from HIV-associated tuberculosis. Int J Tuberc Lung Dis (2011) 2.19
Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci (2001) 2.19
Cardiac autonomic function and incident coronary heart disease: a population-based case-cohort study. The ARIC Study. Atherosclerosis Risk in Communities Study. Am J Epidemiol (1997) 2.17
Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Diabetes Care (1999) 2.17
A novel method to identify gene-gene effects in nuclear families: the MDR-PDT. Genet Epidemiol (2006) 2.17
Usefulness of cardiovascular family history data for population-based preventive medicine and medical research (the Health Family Tree Study and the NHLBI Family Heart Study). Am J Cardiol (2001) 2.14
Prenatal screening for congenital heart disease. Br Med J (Clin Res Ed) (1986) 2.14
Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J Immunol (2000) 2.11
Associations of ankle-brachial index with clinical coronary heart disease, stroke and preclinical carotid and popliteal atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis (1997) 2.11
NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am J Med Genet (1998) 2.09
Correlates of cognitive function in middle-aged adults. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Gerontology (1998) 2.07
Obstetric importance, diagnosis, and management of fetal tachycardias. BMJ (1988) 2.07
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet (2005) 2.06
Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res (1997) 2.06
Apolipoprotein E and cognitive change in an elderly population. Ann Neurol (1996) 2.05
Magnetic resonance elastography of brain tumors: preliminary results. Acta Radiol (2007) 2.04
Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology (2002) 2.02
Involving minority and underrepresented women in clinical trials: the National Centers of Excellence in Women's Health. J Womens Health Gend Based Med (2000) 2.01
Letter: Colonial morphology of Neisseria gonorrhoeae. JAMA (1974) 2.00
Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation (1990) 1.99
Sex-specific associations of magnetic resonance imaging-derived intra-abdominal and subcutaneous fat areas with conventional anthropometric indices. The Atherosclerosis Risk in Communities Study. Am J Epidemiol (1996) 1.99
Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem (2001) 1.99
Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev (2000) 1.96