Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal children.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 3678245)

Published in Bone on May 11, 2011

Authors

Z A Cole1, N C Harvey, M Kim, G Ntani, S M Robinson, H M Inskip, K M Godfrey, C Cooper, E M Dennison, Southampton Women's Survey Study Group

Author Affiliations

1: MRC Lifecourse Epidemiology Unit, (University of Southampton), Southampton General Hospital, Southampton SO16 6YD, UK. zac@mrc.soton.ac.uk

Articles citing this

Growth from birth to adulthood and bone phenotype in early old age: a British birth cohort study. J Bone Miner Res (2014) 0.99

Leptin may play a role in bone microstructural alterations in obese children. J Clin Endocrinol Metab (2014) 0.95

Vitamin D deficiency is associated with prediabetes in obese Swedish children. Acta Paediatr (2016) 0.90

Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur. Bone (2013) 0.90

Fat mass increase in 7-year-old children: more bone area but lower bone mineral density. J Bone Miner Metab (2013) 0.85

Association of weight-adjusted body fat and fat distribution with bone mineral density in middle-aged chinese adults: a cross-sectional study. PLoS One (2013) 0.84

Altered lower extremity fracture characteristics in obese pediatric trauma patients. J Orthop Trauma (2015) 0.83

Influence of body weight on bone mass, architecture and turnover. J Endocrinol (2016) 0.80

Body composition during childhood and adolescence: relations to bone strength and microstructure. J Clin Endocrinol Metab (2014) 0.80

Adequate vitamin D status and adiposity contribute to bone health in peripubertal nonobese children. J Bone Miner Metab (2013) 0.79

Physical activity and bone health in schoolchildren: the mediating role of fitness and body fat. PLoS One (2015) 0.78

Bone density characteristics and major depressive disorder in adolescents. Psychosom Med (2013) 0.77

Associations between adiposity, hormones, and gains in height, whole-body height-adjusted bone size, and size-adjusted bone mineral content in 8- to 11-year-old children. Osteoporos Int (2015) 0.76

Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty. BMC Pediatr (2016) 0.75

Peripheral quantitative computed tomography (pQCT) for the assessment of bone strength in most of bone affecting conditions in developmental age: a review. Ital J Pediatr (2016) 0.75

Estimation of whole body fat from appendicular soft tissue from peripheral quantitative computed tomography in adolescent girls. Int J Body Compos Res (2013) 0.75

Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7 years. Bone (2015) 0.75

Methodological considerations when studying the skeletal response to glucose intolerance using the diet-induced obesity model. Bonekey Rep (2016) 0.75

Body Composition, Nutritional Profile and Muscular Fitness Affect Bone Health in a Sample of Schoolchildren from Colombia: The Fuprecol Study. Nutrients (2017) 0.75

A family-centered lifestyle intervention to improve body composition and bone mass in overweight and obese children 6 through 8 years: a randomized controlled trial study protocol. BMC Public Health (2013) 0.75

Bone-Fat Interaction. Endocrinol Metab Clin North Am (2016) 0.75

Soft tissues, areal bone mineral density and hip geometry estimates in active young boys: the PRO-BONE study. Eur J Appl Physiol (2017) 0.75

Articles cited by this

Cohort profile: The Southampton Women's Survey. Int J Epidemiol (2005) 4.11

PPAR-gamma regulates osteoclastogenesis in mice. Nat Med (2007) 3.59

Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ (2008) 3.56

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology (1999) 2.65

Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology (2004) 2.44

Overweight and obese children have low bone mass and area for their weight. Int J Obes Relat Metab Disord (2000) 2.07

How does body fat influence bone mass in childhood? A Mendelian randomization approach. J Bone Miner Res (2009) 2.01

Adipose tissue stimulates bone growth in prepubertal children. J Clin Endocrinol Metab (2006) 1.90

Increased body weight and decreased radial cross-sectional dimensions in girls with forearm fractures. J Bone Miner Res (2001) 1.86

More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J Bone Miner Res (2000) 1.76

Bone and body composition of children and adolescents with repeated forearm fractures. J Bone Miner Res (2005) 1.69

Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis. J Endocrinol (2004) 1.67

Body size and risk for clinical fractures in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med (2000) 1.57

Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age. Bone (2000) 1.47

Fat and bone in children: differential effects of obesity on bone size and mass according to fracture history. J Bone Miner Res (2010) 1.33

Improvement in the accuracy of dual energy x-ray absorptiometry for whole body and regional analysis of body composition: validation using piglets and methodologic considerations in infants. Pediatr Res (1997) 1.27

Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem (2010) 1.26

Reciprocal control of osteoblast/chondroblast and osteoblast/adipocyte differentiation of multipotential clonal human marrow stromal F/STRO-1(+) cells. J Cell Biochem (2001) 1.24

Diabetes mellitus and the risk of non-vertebral fractures: the Tromsø study. Osteoporos Int (2005) 1.22

Peak bone mineral area density and determinants among females aged 9 to 24 years in Mexico. Osteoporos Int (2003) 1.17

Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study. Bone (1996) 1.14

Sex difference in the effect of puberty on the relationship between fat mass and bone mass in 926 healthy subjects, 6 to 18 years old. Obesity (Silver Spring) (2006) 1.10

Circulating insulin levels are related to bone density in normal postmenopausal women. Am J Physiol (1993) 1.05

Insulin increases histomorphometric indices of bone formation In vivo. Calcif Tissue Int (1996) 1.05

Correlations between insulin sensitivity and bone mineral density in non-diabetic men. Diabet Med (2000) 1.03

Cross-sectional versus longitudinal associations of lean and fat mass with pQCT bone outcomes in children. J Clin Endocrinol Metab (2010) 1.03

Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab (1997) 1.01

Sex differences in the effect of body-composition variables on bone mass in healthy children and adolescents. Am J Clin Nutr (2004) 1.01

Leptin controls bone formation through a hypothalamic relay. Recent Prog Horm Res (2001) 0.95

The role of PPARγ for the osteoblastic differentiation. J Endocrinol Invest (2010) 0.94

Total body bone mineral content and tibial cortical bone measures in preschool children. J Bone Miner Res (2001) 0.90

Adiponectin and its association with bone mass accrual in childhood. J Bone Miner Res (2010) 0.89

Body composition analysis by dual energy X-ray absorptiometry compared to chemical analysis of fat, lean and bone mass in small piglets. Basic Life Sci (1993) 0.85

Leptin: cutting the fat off the bone. Lancet (2003) 0.82

Articles by these authors

Fetal nutrition and cardiovascular disease in adult life. Lancet (1993) 12.55

Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet (2005) 8.49

The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int (2007) 6.44

Risk of new vertebral fracture in the year following a fracture. JAMA (2001) 6.17

Epidemiology of fractures in England and Wales. Bone (2001) 5.76

Multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi. J Clin Microbiol (1997) 5.64

European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int (2008) 5.27

Perspective. How many women have osteoporosis? J Bone Miner Res (1992) 4.99

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet (2006) 4.95

European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int (2012) 4.88

Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ (1991) 4.87

Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann Rheum Dis (1992) 4.79

Use of oral corticosteroids and risk of fractures. J Bone Miner Res (2000) 4.75

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain. Genes Dev (2001) 4.64

EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis (2000) 4.37

Roles for Nkx3.1 in prostate development and cancer. Genes Dev (1999) 4.30

The public versus the World Health Organization on health system performance. Health Aff (Millwood) (2001) 3.96

Bone density screening for osteoporosis. Lancet (1990) 3.87

Defining osteoarthritis of the hip for epidemiologic studies. Am J Epidemiol (1990) 3.77

Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int (2009) 3.74

Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos (2013) 3.64

Cohort profile: the Hertfordshire cohort study. Int J Epidemiol (2005) 3.62

A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int (2012) 3.62

Bone densitometry in clinical practice. BMJ (1995) 3.48

The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int (2002) 3.45

Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int (2010) 3.36

"Occult" hepatitis B virus as source of infection in liver transplant recipients. Lancet (1994) 3.33

The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res (1996) 3.25

Determinants of disability in osteoarthritis of the knee. Ann Rheum Dis (1993) 3.16

Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res (2002) 3.16

Fluoride in drinking water and risk of hip fracture in the UK: a case-control study. Lancet (2000) 3.16

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci (2000) 3.16

Knee pain and disability in the community. Br J Rheumatol (1992) 3.15

Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int (2011) 3.04

Pectin esterification is spatially regulated both within cell walls and between developing tissues of root apices. Planta (1990) 3.03

GP job satisfaction in 1987, 1990 and 1998: lessons for the future? Fam Pract (2000) 2.99

Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum (2003) 2.94

Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr (2007) 2.94

Results of indirect and mixed treatment comparison of fracture efficacy for osteoporosis treatments: a meta-analysis. Osteoporos Int (2012) 2.81

Effect of annual intramuscular vitamin D on fracture risk in elderly men and women--a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford) (2007) 2.81

Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporos Int (1997) 2.80

Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas (2009) 2.74

Back pain in Britain: comparison of two prevalence surveys at an interval of 10 years. BMJ (2000) 2.73

Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int (1999) 2.70

A global representation of vitamin D status in healthy populations. Arch Osteoporos (2012) 2.69

Osteoarthritis of the hip: an occupational disease in farmers. BMJ (1992) 2.69

HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol (2000) 2.60

Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures. J Bone Miner Res (2000) 2.55

Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study. BMJ (2009) 2.54

Occupational physical activities and osteoarthritis of the knee. Arthritis Rheum (2000) 2.54

Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem (1999) 2.51

Membrane ultrafiltration: the diafiltration technique and its application to microsolute exchange and binding phenomena. Anal Biochem (1968) 2.50

Manual handling activities and risk of low back pain in nurses. Occup Environ Med (1995) 2.48

Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporos Int (2012) 2.48

Use of statins and risk of fractures. JAMA (2001) 2.47

Prospective cohort study of predictors of incident low back pain in nurses. BMJ (1997) 2.46

Impact of educational attainment on the quality of young women's diets. Eur J Clin Nutr (2004) 2.44

Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology (2008) 2.44

Interpretation and use of FRAX in clinical practice. Osteoporos Int (2011) 2.43

Fear-potentiated startle: a neural and pharmacological analysis. Behav Brain Res (1993) 2.43

A UK Consensus Group on management of glucocorticoid-induced osteoporosis: an update. J Intern Med (1998) 2.42

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage (2010) 2.39

The relation of fetal length, ponderal index and head circumference to blood pressure and the risk of hypertension in adult life. Paediatr Perinat Epidemiol (1992) 2.39

Risk factors for transmission of hepatitis B virus to Gambian children. Lancet (1990) 2.35

Trends in admissions for hip fracture in England and Wales, 1968-85. BMJ (1990) 2.35

Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem (1997) 2.34

Nanoscale nuclear magnetic resonance with a nitrogen-vacancy spin sensor. Science (2013) 2.33

Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord (2001) 2.30

Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air. Occup Environ Med (2000) 2.29

Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum (2006) 2.28

How accurate are diagnoses for rheumatoid arthritis and juvenile idiopathic arthritis in the general practice research database? Arthritis Rheum (2008) 2.27

Risk of fractures in patients with multiple sclerosis: a population-based cohort study. Neurology (2012) 2.25

Vertebral fractures predict subsequent fractures. Osteoporos Int (1999) 2.24

Dietary calcium, physical activity, and risk of hip fracture: a prospective study. BMJ (1989) 2.24

A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study. Rheumatology (Oxford) (2005) 2.23

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection. Health Technol Assess (2007) 2.23

Acetabular dysplasia and hip osteoarthritis in Britain and Japan. Br J Rheumatol (1998) 2.22

Bacterial arthritis in an English health district: a 10 year review. Ann Rheum Dis (1986) 2.21

Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int (1999) 2.20

Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men. HIV Med (2008) 2.19

Do bedbugs transmit hepatitis B? Lancet (1994) 2.17

Vitamin D and skeletal health in infancy and childhood. Osteoporos Int (2014) 2.16

Comparison of two assays for measuring plasma concentrations of paracetamol. BMJ (1997) 2.14

Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford) (2000) 2.13

The changing use of disease-modifying anti-rheumatic drugs in individuals with rheumatoid arthritis from the United Kingdom General Practice Research Database. Rheumatology (Oxford) (2005) 2.11

Physical activity at 36 years: patterns and childhood predictors in a longitudinal study. J Epidemiol Community Health (1992) 2.11

Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology (1992) 2.09

Classification and definition of major flares in SLE clinical trials. Lupus (1999) 2.02

Use of oral corticosteroids in the United Kingdom. QJM (2000) 1.95