Published in Oncogene on June 13, 2011
The dynamic nature of autophagy in cancer. Genes Dev (2011) 3.57
Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology (2013) 2.21
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO J (2013) 1.26
Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment. Oncotarget (2012) 1.14
Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol (2014) 1.04
Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53. PLoS Pathog (2013) 1.00
Novel therapies in glioblastoma. Neurol Res Int (2012) 0.97
The fate of chemoresistance in triple negative breast cancer (TNBC). BBA Clin (2015) 0.94
Autophagy modulation as a target for anticancer drug discovery. Acta Pharmacol Sin (2013) 0.93
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis. Oncotarget (2012) 0.90
The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Dev Cell (2013) 0.87
Arginine dependence of tumor cells: targeting a chink in cancer's armor. Oncogene (2016) 0.86
Glutaminolysis and autophagy in cancer. Autophagy (2015) 0.86
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours. Br J Cancer (2013) 0.82
Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells. Mol Med Rep (2015) 0.79
The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo. Part Fibre Toxicol (2016) 0.79
AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One (2015) 0.78
Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice. Clin Exp Metastasis (2015) 0.77
Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy. Oncotarget (2016) 0.77
Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration. Autophagy (2016) 0.76
Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells. Oncotarget (2017) 0.75
The Histone Deacetylase Gene Rpd3 Is Required for Starvation Stress Resistance. PLoS One (2016) 0.75
Epigenetic regulation of starvation-induced autophagy in Drosophila by histone methyltransferase G9a. Sci Rep (2017) 0.75
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science (1997) 7.07
A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J (1996) 6.08
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem (1995) 5.57
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res (2000) 4.62
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res (1998) 4.52
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev (2000) 3.86
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature (2001) 2.50
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res (2000) 2.20
PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci (1997) 2.19
Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem (1999) 2.08
Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem (1993) 2.02
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int Immunol (1999) 2.00
T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1. J Biol Chem (1991) 1.97
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res (1999) 1.89
Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity (1996) 1.87
Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol Cell Biol (1992) 1.87
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem (2000) 1.83
Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. J Biol Chem (1993) 1.74
Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism. J Biol Chem (1987) 1.60
Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. J Exp Med (1992) 1.55
Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function. Proc Natl Acad Sci U S A (1991) 1.53
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol Cell Biol (1995) 1.52
Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO J (1999) 1.51
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol (2000) 1.51
Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP. J Immunol (1988) 1.49
A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. J Biol Chem (1995) 1.46
Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol (1998) 1.41
Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. J Biol Chem (1993) 1.36
Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res (1995) 1.34
Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J Exp Med (1994) 1.23
Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol (1990) 1.22
Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters. J Biol Chem (1989) 1.20
Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes. J Biol Chem (1993) 1.19
Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells. J Biol Chem (1995) 1.15
Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem (2001) 1.14
Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol Cell Biol (1991) 1.10
The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line. J Exp Med (1994) 1.10
SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem (1998) 1.06
Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine. J Biol Chem (1990) 1.05
Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells. Biochim Biophys Acta (1990) 1.00
Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells. J Immunol (1990) 0.98
Ligation of the beta2 integrin triggers activation and degranulation of human eosinophils. Am J Respir Cell Mol Biol (1998) 0.98
Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate. J Immunol (1991) 0.97
Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. J Exp Med (1997) 0.97
Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J Immunol (1987) 0.96
Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol (1994) 0.95
Fc gamma receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G protein-independent, but tyrosine kinase-dependent pathway. J Immunol (1991) 0.95
Tyrosine phosphorylation is required for eosinophil degranulation induced by immobilized immunoglobulins. J Immunol (1995) 0.93
A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf. J Biol Chem (1999) 0.92
Correlates of youth smokeless tobacco use. Nicotine Tob Res (2000) 0.92
Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol (1999) 0.92
Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol (1999) 0.92
Transmembrane signaling during natural killer cell-mediated cytotoxicity. Regulation by protein kinase C activation. J Immunol (1990) 0.90
Cytokine receptor signaling mechanisms. Curr Opin Immunol (1995) 0.89
Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways. J Biol Chem (1998) 0.89
ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. J Immunol (1997) 0.87
Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem (1995) 0.87
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. J Biol Chem (1993) 0.86
Differential bioassay of interleukin 2 and interleukin 4. J Immunol Methods (1987) 0.86
Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism. J Immunol (1991) 0.85
Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues. Cancer Chemother Pharmacol (1994) 0.84
Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis. J Biol Chem (1992) 0.84
Interleukin-2 receptor signaling mechanisms. Adv Immunol (1996) 0.83
Protein-tyrosine kinase-dependent activation of STAT transcription factors in interleukin-2- or interleukin-4-stimulated T lymphocytes. J Biol Chem (1995) 0.83
Stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent T cell line. J Immunopharmacol (1986) 0.82
Synthesis and pH-dependent stability of purine-6-sulfenic acid, a putative reactive metabolite of 6-thiopurine. J Med Chem (1983) 0.81
Correlation of low and high affinity thiol methyltransferase and phenol methyltransferase activities in human erythrocyte membranes. Clin Chim Acta (1983) 0.79
Differential responsiveness to phorbol esters correlates with differential expression of protein kinase C in KG-1 and KG-1a human myeloid leukemia cells. Biochim Biophys Acta (1989) 0.79
Redox regulation of calcineurin in T-lymphocytes. J Biol Inorg Chem (1999) 0.79
Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate. Cancer Res (1993) 0.78
Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation. J Immunol (1991) 0.78
Doxorubicin blocks the increase in intracellular Ca++, part of a second messenger system in N1E-115 murine neuroblastoma cells. J Pharmacol Exp Ther (1990) 0.78
Regulation of growth of an interleukin 2 (IL-2)-dependent murine T-cell clone (HT-2) in a defined serum-free medium. Cell Immunol (1985) 0.77
Condensed tannin promotes the release of arachidonic acid from rabbit resident alveolar macrophages. Am J Respir Cell Mol Biol (1992) 0.77
Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem (2001) 0.77
Cyclosporine in the treatment of dermatologic disease: an update. Mayo Clin Proc (1996) 0.77
A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity. Anticancer Drug Des (1994) 0.77
Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase. Anticancer Drug Des (1995) 0.76
Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase. Bioorg Med Chem (2000) 0.76
Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways. Methods Mol Biol (2000) 0.76
A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors. Anticancer Res (1995) 0.76
Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency. J Clin Immunol (1991) 0.76
Effect of drug vehicles on N-demethylase activity in isolated hepatocytes. Biochem Pharmacol (1980) 0.75
Influence of hepatic oxidative metabolism on the immunosuppressive activities of 6-thiopurines. J Pharmacol Exp Ther (1985) 0.75
Interleukin-2 signal transduction in human NK cells: multisite phosphorylation and activation of the tyrosine kinase p56lck. J Leukoc Biol (1992) 0.75
Factors influencing dimethylphenobarbital N-demethylation by isolated hepatocytes from untreated and phenobarbital-treated rats. Drug Metab Dispos (1980) 0.75
Signal transduction mechanisms in human natural killer cells mediating antitumor immunity. Haematol Blood Transfus (1989) 0.75
Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel. J Med Chem (1998) 0.75
Barbiturate N-demethylase activity in isolated rat hepatocytes. Anal Biochem (1983) 0.75
Reductive metabolism of furazolidone by Escherichia coli and rat liver in vitro. Drug Metab Dispos (1985) 0.75
Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues. Cancer Chemother Pharmacol (1997) 0.75
Tyrosine phosphorylation and inositol phosphate production: are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? J Allergy Clin Immunol (1994) 0.75
Fc receptor stimulation of PI 3-kinase in NK cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. Ann N Y Acad Sci (1995) 0.75