Published in Hum Mol Genet on June 13, 2011
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest (2012) 2.66
The bad taste of medicines: overview of basic research on bitter taste. Clin Ther (2013) 1.10
Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31. Chem Senses (2013) 1.02
Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. Am J Clin Nutr (2013) 1.00
Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food Qual Prefer (2013) 0.97
Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer. Chem Senses (2012) 0.95
Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans. PLoS One (2012) 0.91
Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in TAS2R9 and TAS2R31. Chemosens Percept (2013) 0.89
A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs. BMC Neurosci (2015) 0.84
Genetics of taste receptors. Curr Pharm Des (2014) 0.84
Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. J Leukoc Biol (2015) 0.83
Genetic signature of differential sensitivity to stevioside in the Italian population. Genes Nutr (2014) 0.83
Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes). PLoS One (2012) 0.83
Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception. PLoS Genet (2015) 0.83
Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physiol Behav (2016) 0.81
Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31. Chem Senses (2015) 0.81
Determinants of taste preference and acceptability: quality versus hedonics. J Neurosci (2012) 0.80
Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice. Neuroscience (2013) 0.79
Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants. Chem Senses (2012) 0.79
Taste function in early stage treated and untreated Parkinson's disease. J Neurol (2014) 0.78
Multiple loss-of-function variants of taste receptors in modern humans. Sci Rep (2015) 0.78
Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN). BMC Med Genet (2012) 0.77
Association analysis of bitter receptor genes in five isolated populations identifies a significant correlation between TAS2R43 variants and coffee liking. PLoS One (2014) 0.77
Taste dysfunction in multiple sclerosis. J Neurol (2016) 0.77
Examination of the perception of sweet- and bitter-like taste qualities in sucralose preferring and avoiding rats. Physiol Behav (2014) 0.76
Loss of gene function and evolution of human phenotypes. BMB Rep (2015) 0.75
Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults. Sci Rep (2016) 0.75
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells. Proc Natl Acad Sci U S A (2017) 0.75
The Taste of Caffeine. J Caffeine Res (2017) 0.75
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87
Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A (2007) 5.95
Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med (2008) 5.82
Signatures of natural selection in the human genome. Nat Rev Genet (2003) 3.84
The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses (2009) 3.45
The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol (2005) 3.41
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology (2015) 2.81
The cells and peripheral representation of sodium taste in mice. Nature (2010) 2.80
Genetic variation, classification and 'race'. Nat Genet (2004) 2.63
Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet (2008) 2.53
The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet (2002) 2.34
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature (2011) 2.31
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. PLoS One (2010) 2.19
Bitter taste receptors for saccharin and acesulfame K. J Neurosci (2004) 2.09
PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome. Am J Hum Genet (2010) 2.05
Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. PLoS Genet (2009) 1.81
Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr Biol (2005) 1.79
Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature (2006) 1.59
Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem (2007) 1.59
Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav (2011) 1.57
Evaluation of a novel anti-mucin 1 (MUC1) antibody (PankoMab) as a potential diagnostic tool in human ductal breast cancer; comparison with two established antibodies. Onkologie (2009) 1.51
Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet (2005) 1.49
Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci (2007) 1.48
Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol (2007) 1.43
G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci U S A (2011) 1.41
Regulation and function of somatostatin receptors. J Neurochem (2004) 1.40
The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem Biophys Res Commun (2004) 1.36
Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. J Biol Chem (2004) 1.34
Cryptic chromosomal abnormalities identified in children with congenital heart disease. Pediatr Res (2008) 1.31
Structural requirements of bitter taste receptor activation. Proc Natl Acad Sci U S A (2010) 1.23
A TAS1R receptor-based explanation of sweet 'water-taste'. Nature (2006) 1.20
G protein-coupled receptors in human fat taste perception. Chem Senses (2011) 1.18
Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3. Br J Pharmacol (2011) 1.18
The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC Struct Biol (2007) 1.17
Members of RTP and REEP gene families influence functional bitter taste receptor expression. J Biol Chem (2006) 1.17
Adjusting for covariates in logistic regression models. Genet Epidemiol (2010) 1.17
Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci (2005) 1.16
Taste responses in mice lacking taste receptor subunit T1R1. J Physiol (2013) 1.15
Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. PLoS One (2010) 1.12
Blindly using Wald's test can miss rare disease-causal variants in case-control association studies. Ann Hum Genet (2012) 1.11
Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol (2010) 1.09
Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer (2007) 1.06
Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem Senses (2010) 1.06
Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population. PLoS One (2009) 1.05
Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations. J Thorac Oncol (2014) 1.04
Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence. Anticancer Res (2007) 1.03
Oral and extraoral bitter taste receptors. Results Probl Cell Differ (2010) 1.03
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin. J Agric Food Chem (2009) 1.02
Receptor agonism and antagonism of dietary bitter compounds. J Neurosci (2011) 0.99
Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. J Clin Invest (2013) 0.97
Oligomerization of TAS2R bitter taste receptors. Chem Senses (2010) 0.97
Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China. Hepatology (2012) 0.95
Different phenolic compounds activate distinct human bitter taste receptors. J Agric Food Chem (2013) 0.95
Sweet and umami taste: natural products, their chemosensory targets, and beyond. Angew Chem Int Ed Engl (2011) 0.95
The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci (2013) 0.94
Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans. PLoS One (2011) 0.94
Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception. Chem Senses (2013) 0.94
The human vomeronasal type-1 receptor family--detection of volatiles and cAMP signaling in HeLa/Olf cells. FASEB J (2007) 0.94
Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci (2014) 0.94
Immunohistochemical detection of TAS2R38 protein in human taste cells. PLoS One (2012) 0.93
Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa. PLoS One (2012) 0.93
Amino acids and peptides activate at least five members of the human bitter taste receptor family. J Agric Food Chem (2012) 0.92
Human psychometric and taste receptor responses to steviol glycosides. J Agric Food Chem (2012) 0.92
Placental interleukin-15 expression in recurrent miscarriage. Am J Reprod Immunol (2010) 0.92
Binding of galectin-1 (gal-1) to the Thomsen-Friedenreich (TF) antigen on trophoblast cells and inhibition of proliferation of trophoblast tumor cells in vitro by gal-1 or an anti-TF antibody. Histochem Cell Biol (2006) 0.92
Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice. Cancer Res (2008) 0.91
Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. J Histochem Cytochem (2005) 0.91
Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes. Peptides (2011) 0.91
Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS One (2013) 0.91