Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
|
Science
|
2011
|
13.16
|
2
|
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
|
Science
|
2009
|
10.78
|
3
|
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.
|
J Biol Chem
|
2004
|
6.55
|
4
|
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3.
|
Nucleic Acids Res
|
2006
|
2.09
|
5
|
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.
|
Nat Struct Mol Biol
|
2004
|
1.78
|
6
|
Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1.
|
Structure
|
2012
|
1.77
|
7
|
Optical orbital angular momentum from the curl of polarization.
|
Phys Rev Lett
|
2010
|
1.68
|
8
|
Structural and molecular interactions of CCR5 inhibitors with CCR5.
|
J Biol Chem
|
2006
|
1.55
|
9
|
Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
|
Cell Res
|
2010
|
1.45
|
10
|
Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36.
|
J Biol Chem
|
2008
|
1.26
|
11
|
Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.
|
Protein Sci
|
2006
|
1.25
|
12
|
Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site.
|
Biochem J
|
2007
|
1.23
|
13
|
Structural basis for the unique biological function of small GTPase RHEB.
|
J Biol Chem
|
2005
|
1.19
|
14
|
Expression, purification, and characterization of SARS coronavirus RNA polymerase.
|
Virology
|
2005
|
1.19
|
15
|
Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design.
|
Nucleic Acids Res
|
2003
|
1.18
|
16
|
Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.
|
Proc Natl Acad Sci U S A
|
2009
|
1.13
|
17
|
Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins.
|
J Mol Cell Biol
|
2011
|
1.13
|
18
|
Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20.
|
Mol Immunol
|
2009
|
1.12
|
19
|
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis.
|
Nature
|
2013
|
1.11
|
20
|
Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity.
|
J Biol Chem
|
2003
|
1.10
|
21
|
Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.
|
Structure
|
2009
|
1.07
|
22
|
A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13.
|
Blood
|
2011
|
1.06
|
23
|
Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation.
|
Nat Struct Mol Biol
|
2010
|
1.04
|
24
|
Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding.
|
Nucleic Acids Res
|
2011
|
1.04
|
25
|
Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication.
|
EMBO J
|
2009
|
1.03
|
26
|
Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity.
|
Nucleic Acids Res
|
2006
|
1.02
|
27
|
The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14.
|
Protein Sci
|
2006
|
1.02
|
28
|
Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis.
|
Protein Sci
|
2008
|
1.02
|
29
|
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.
|
J Biol Chem
|
2007
|
1.01
|
30
|
Structural basis for recognition of CD20 by therapeutic antibody Rituximab.
|
J Biol Chem
|
2007
|
1.00
|
31
|
Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states.
|
Nucleic Acids Res
|
2008
|
1.00
|
32
|
Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification.
|
Cell Res
|
2012
|
0.99
|
33
|
Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274.
|
Cell Res
|
2011
|
0.99
|
34
|
Generation of arbitrary vector beams with a spatial light modulator and a common path interferometric arrangement.
|
Opt Lett
|
2007
|
0.98
|
35
|
Computational simulations of interactions of scorpion toxins with the voltage-gated potassium ion channel.
|
Biophys J
|
2004
|
0.98
|
36
|
Steered molecular dynamics simulation on the binding of NNRTI to HIV-1 RT.
|
Biophys J
|
2003
|
0.97
|
37
|
Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
|
Virology
|
2009
|
0.95
|
38
|
Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein.
|
J Biol Chem
|
2009
|
0.94
|
39
|
Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay.
|
Protein Sci
|
2008
|
0.94
|
40
|
A new type of vector fields with hybrid states of polarization.
|
Opt Express
|
2010
|
0.94
|
41
|
Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.
|
J Mol Biol
|
2006
|
0.93
|
42
|
Crystal structure of D-Hydantoinase from Burkholderia pickettii at a resolution of 2.7 Angstroms: insights into the molecular basis of enzyme thermostability.
|
J Bacteriol
|
2003
|
0.92
|
43
|
Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
|
Cell Res
|
2013
|
0.91
|
44
|
X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis.
|
FEBS J
|
2009
|
0.91
|
45
|
Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction.
|
Protein Sci
|
2008
|
0.91
|
46
|
Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.
|
J Mol Biol
|
2008
|
0.91
|
47
|
Saccharomyces cerevisiae MHF complex structurally resembles the histones (H3-H4)₂ heterotetramer and functions as a heterotetramer.
|
Structure
|
2012
|
0.89
|
48
|
Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination.
|
Biochem J
|
2006
|
0.89
|
49
|
Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori.
|
Proteins
|
2008
|
0.88
|
50
|
SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation.
|
Mol Cell Biol
|
2010
|
0.86
|
51
|
Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab.
|
J Immunol
|
2009
|
0.86
|
52
|
Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme.
|
Protein Sci
|
2005
|
0.84
|
53
|
Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism.
|
Biochem J
|
2011
|
0.84
|
54
|
Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain.
|
Arch Virol
|
2009
|
0.84
|
55
|
Involvement of the C-terminal proline-rich motif of G protein-coupled receptor kinases in recognition of activated rhodopsin.
|
J Biol Chem
|
2004
|
0.84
|
56
|
The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis.
|
J Biol Chem
|
2008
|
0.84
|
57
|
Generation of vector beam with space-variant distribution of both polarization and phase.
|
Opt Lett
|
2011
|
0.83
|
58
|
Complete shaping of optical vector beams.
|
Opt Express
|
2015
|
0.83
|
59
|
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
|
J Biol Chem
|
2007
|
0.83
|
60
|
Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide.
|
Mol Immunol
|
2008
|
0.83
|
61
|
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif.
|
Biochem J
|
2013
|
0.83
|
62
|
Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site.
|
J Struct Biol
|
2009
|
0.83
|
63
|
Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans.
|
Biochem J
|
2008
|
0.82
|
64
|
Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design.
|
Nucleic Acids Res
|
2010
|
0.82
|
65
|
Optical trapping with focused Airy beams.
|
Appl Opt
|
2011
|
0.82
|
66
|
A conserved hydrophobic core at Bcl-xL mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein.
|
Arch Biochem Biophys
|
2009
|
0.81
|
67
|
Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase.
|
Nucleic Acids Res
|
2009
|
0.81
|
68
|
Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization.
|
BMC Microbiol
|
2009
|
0.81
|
69
|
Functional and structural characterization of DNMT2 from Spodoptera frugiperda.
|
J Mol Cell Biol
|
2012
|
0.80
|
70
|
Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin.
|
Cell Res
|
2012
|
0.80
|
71
|
Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair.
|
Nucleic Acids Res
|
2013
|
0.80
|
72
|
Structural basis of immunosuppression by the therapeutic antibody daclizumab.
|
Cell Res
|
2010
|
0.80
|
73
|
Light field shaping by tailoring both phase and polarization.
|
Appl Opt
|
2014
|
0.79
|
74
|
FDTD approach to optical forces of tightly focused vector beams on metal particles.
|
Opt Express
|
2009
|
0.79
|
75
|
Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans.
|
Biochem J
|
2009
|
0.79
|
76
|
Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis.
|
J Mol Biol
|
2008
|
0.79
|
77
|
Radial Hilbert transform with Laguerre-Gaussian spatial filters.
|
Opt Lett
|
2006
|
0.79
|
78
|
Distinct and redundant roles of the two MYST histone acetyltransferases Esa1 and Sas2 in cell growth and morphogenesis of Candida albicans.
|
Eukaryot Cell
|
2013
|
0.78
|
79
|
Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism.
|
J Struct Biol
|
2013
|
0.78
|
80
|
Ultrastructural changes in goat interspecies and intraspecies reconstructed early embryos.
|
Zygote
|
2008
|
0.78
|
81
|
Two-dimensional wavefront reconstruction from lateral multi-shear interferograms.
|
Opt Express
|
2012
|
0.77
|
82
|
Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of beta-2-microglobulin by antibody BBM.1.
|
J Mol Recognit
|
2009
|
0.76
|
83
|
Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism.
|
Biochem J
|
2013
|
0.76
|
84
|
Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism.
|
Biochem J
|
2011
|
0.76
|
85
|
New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4.
|
Acta Biochim Biophys Sin (Shanghai)
|
2011
|
0.76
|
86
|
A lower baseline glomerular filtration rate predicts high mortality and newly cerebrovascular accidents in acute ischemic stroke patients.
|
Medicine (Baltimore)
|
2017
|
0.75
|
87
|
Crystal structures of human CaMKIα reveal insights into the regulation mechanism of CaMKI.
|
PLoS One
|
2012
|
0.75
|
88
|
Polarization structuring of focused field through polarization-only modulation of incident beam.
|
Opt Lett
|
2010
|
0.75
|
89
|
Shaping of optical vector beams in three dimensions.
|
Opt Lett
|
2017
|
0.75
|
90
|
Phase contrast Talbot array illuminators.
|
Opt Lett
|
2008
|
0.75
|
91
|
Z-scan theory for material with two- and three-photon absorption.
|
Opt Express
|
2005
|
0.75
|
92
|
Three-wave shearing interferometer based on spatial light modulator.
|
Opt Express
|
2009
|
0.75
|
93
|
Saturation effect and forward-dominant second-harmonic generation in single-defect photonic crystals with dual localizations.
|
Opt Lett
|
2006
|
0.75
|
94
|
[A new approach to wavelet-based P-wave detection].
|
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
|
2006
|
0.75
|
95
|
Mild encephalopathy with a reversible splenial lesion mimicking transient ischemic attack: A case report.
|
Medicine (Baltimore)
|
2016
|
0.75
|
96
|
Expression, purification, crystallization and preliminary structural characterization of the GTPase domain of human Rheb.
|
Acta Crystallogr D Biol Crystallogr
|
2004
|
0.75
|
97
|
Self-focusing hidden bar code.
|
Appl Opt
|
2002
|
0.75
|
98
|
Reverse engineering approach to focus shaping.
|
Opt Lett
|
2016
|
0.75
|
99
|
Generalized phase-shifting for three-wave shearing interferometry.
|
Appl Opt
|
2016
|
0.75
|
100
|
A new planar left-handed metamaterial composed of metal-dielectric-metal structure.
|
Opt Express
|
2008
|
0.75
|
101
|
Two-dimensional wave-front reconstruction from lateral shearing interferograms.
|
Opt Express
|
2006
|
0.75
|
102
|
Polarization-selective diffractive optical elements with a twisted-nematic liquid-crystal display.
|
Appl Opt
|
2010
|
0.75
|
103
|
Fibroblast cell line establishment, cryopreservation and interspecies embryos reconstruction in red panda ( Ailurus fulgens).
|
Zygote
|
2009
|
0.75
|
104
|
Recovery of wavefront from multi-shear interferograms with different tilts.
|
Opt Express
|
2014
|
0.75
|
105
|
Synthesis of Vinyl Trifluoromethyl Thioethers via Copper-Mediated Trifluoromethylthiolation of Vinyl Bromides.
|
J Org Chem
|
2015
|
0.75
|