Published in Acta Neuropathol on June 21, 2011
Treadmill exercise ameliorates short-term memory disturbance in scopolamine-induced amnesia rats. Int Neurourol J (2014) 1.03
Grey matter damage in multiple sclerosis: a pathology perspective. Prion (2013) 0.93
Neuroendocrine immunoregulation in multiple sclerosis. Clin Dev Immunol (2013) 0.87
Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis. Nat Rev Neurol (2015) 0.85
Ginkgo biloba does not improve cognitive function in MS: a randomized placebo-controlled trial. Neurology (2012) 0.84
Epigenetic regulation of estrogen-dependent memory. Front Neuroendocrinol (2014) 0.83
Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease. PLoS One (2013) 0.83
Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis. Acta Neuropathol Commun (2014) 0.82
Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis. PLoS One (2015) 0.81
Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes. Front Mol Neurosci (2016) 0.80
Gray Matter Pathology in MS: Neuroimaging and Clinical Correlations. Mult Scler Int (2013) 0.80
Network collapse and cognitive impairment in multiple sclerosis. Front Neurol (2015) 0.79
Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis. PLoS One (2013) 0.79
Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients. Acta Neuropathol Commun (2014) 0.78
Neurobehavioral burden of multiple sclerosis with nanotheranostics. Neuropsychiatr Dis Treat (2015) 0.75
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
Axonal transection in the lesions of multiple sclerosis. N Engl J Med (1998) 12.21
The medial temporal lobe. Annu Rev Neurosci (2004) 11.98
A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. J Histochem Cytochem (1964) 10.70
The cholinergic hypothesis of geriatric memory dysfunction. Science (1982) 6.84
Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet (1976) 6.09
Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev (2006) 5.81
Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology (1991) 5.69
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (1982) 5.63
A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem (1975) 4.29
The cholinergic hypothesis of Alzheimer's disease: a review of progress. J Neurol Neurosurg Psychiatry (1999) 3.98
Central cholinergic systems and cognition. Annu Rev Psychol (1997) 3.80
Cognitive impairment in multiple sclerosis. Lancet Neurol (2008) 3.77
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J (1978) 3.59
Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Neurology (2004) 2.86
Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). J Int Neuropsychol Soc (2006) 2.58
Human memory and the cholinergic system. A relationship to aging? Arch Neurol (1974) 2.24
Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J Neurol Sci (1982) 2.17
Neocortical neuronal, synaptic, and glial loss in multiple sclerosis. Neurology (2006) 2.10
Regional hippocampal atrophy in multiple sclerosis. Brain (2008) 2.02
Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients. Ann Neurol (2011) 1.98
Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol (1978) 1.82
Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol (2003) 1.79
Extensive hippocampal demyelination in multiple sclerosis. J Neuropathol Exp Neurol (2007) 1.40
Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis. Brain Pathol (2008) 1.32
Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol (2009) 1.30
Presynaptic cholinergic dysfunction in patients with dementia. J Neurochem (1983) 1.28
Rapid quantification of myocardial fibrosis: a new macro-based automated analysis. Cell Oncol (Dordr) (2011) 1.22
The cholinergic innervation of the human cerebral cortex. Prog Brain Res (2004) 1.10
Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine. Brain (2003) 1.04
Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. J Neuroimmunol (2008) 1.03
Smaller cornu ammonis 2-3/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms. Biol Psychiatry (2010) 1.03
In vivo MR imaging of hippocampal lesions in multiple sclerosis. J Magn Reson Imaging (2008) 1.02
Structural and functional hippocampal changes in multiple sclerosis patients with intact memory function. Radiology (2010) 1.00
Hypothalamic lesions in multiple sclerosis. J Neuropathol Exp Neurol (2001) 0.95
The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases. Neurochem Res (2007) 0.92
Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients. Brain Res (1983) 0.90
Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats. Proc Natl Acad Sci U S A (2005) 0.88
Detecting cognitive dysfunction in multiple sclerosis with a magnetic resonance imaging rating scale: a pilot study. CNS Spectr (2005) 0.87
Cholinergic deficits contribute to behavioral disturbance in patients with dementia. Neurology (2000) 0.86
Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment. Mult Scler (2011) 0.79
The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia (2010) 6.23
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med (2010) 4.61
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93
Detection of human papillomavirus in human focal cortical dysplasia type IIB. Ann Neurol (2012) 3.71
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science (2011) 3.52
Inflammation in neurodegenerative diseases. Immunology (2010) 3.22
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis (2007) 2.81
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry (2010) 2.44
Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol (2012) 2.32
Homogeneity of active demyelinating lesions in established multiple sclerosis. Ann Neurol (2008) 2.29
tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat Genet (2008) 2.28
A randomised cross-over trial investigating the ease of use and preference of two dry powder inhalers in patients with asthma or chronic obstructive pulmonary disease. Expert Opin Drug Deliv (2013) 2.13
Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients. Arterioscler Thromb Vasc Biol (2008) 2.10
HPV testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening: cohort study. BMJ (2010) 2.10
Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability. Mult Scler (2011) 2.07
New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. Pediatr Neurol (2013) 2.01
Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Lancet (2012) 1.88
Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci (2006) 1.88
mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann Neurol (2004) 1.85
Receptor conversion in distant breast cancer metastases. Breast Cancer Res (2010) 1.85
Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med (2008) 1.83
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain (2012) 1.82
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia (2013) 1.82
A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp. J Exp Med (2003) 1.80
A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest (2011) 1.79
The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions. J Neuropathol Exp Neurol (2005) 1.76
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol (2012) 1.76
Association between pathological and MRI findings in multiple sclerosis. Lancet Neurol (2012) 1.70
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol (2013) 1.68
Improved detection of active multiple sclerosis lesions: 3D subtraction imaging. Radiology (2010) 1.68
Epilepsy and brain inflammation. Exp Neurol (2011) 1.67
Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease. Neurodegener Dis (2010) 1.66
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci (2004) 1.66
Will the real multiple sclerosis please stand up? Nat Rev Neurosci (2012) 1.61
Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia (2003) 1.60
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response. PLoS One (2012) 1.59
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J Neuroinflammation (2013) 1.59
Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch Neurol (2003) 1.55
Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol (2002) 1.54
Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future. Alzheimers Dement (2013) 1.51
Fractalkine/CX3CL1 modulates GABAA currents in human temporal lobe epilepsy. Epilepsia (2013) 1.50
T-cell-mediated inflammatory activity in the stellate ganglia of patients with ion-channel disease and severe ventricular arrhythmias. Circ Arrhythm Electrophysiol (2014) 1.45
Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci (2002) 1.44
Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla. Eur Radiol (2010) 1.41
Resting state networks change in clinically isolated syndrome. Brain (2010) 1.41
Extensive hippocampal demyelination in multiple sclerosis. J Neuropathol Exp Neurol (2007) 1.40
The molecular basis of neurodegeneration in multiple sclerosis. FEBS Lett (2011) 1.39
Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology (2010) 1.39
Confocal 3D DNA cytometry: assessment of required coefficient of variation by computer simulation. Cell Oncol (2004) 1.39
Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement. Brain (2008) 1.38
Glia as a source of cytokines: implications for neuronal excitability and survival. Epilepsia (2008) 1.38
Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs Aging (2004) 1.36
Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration? Mitochondrion (2010) 1.34
Pontocerebellar hypoplasia type 2: a neuropathological update. Acta Neuropathol (2007) 1.32
Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol (2007) 1.32
Inflammation in neurodegenerative diseases--an update. Immunology (2014) 1.30
Enhanced number and activity of mitochondria in multiple sclerosis lesions. J Pathol (2009) 1.29
Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy. Antioxid Redox Signal (2011) 1.29
Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. Brain (2011) 1.28
Diffusely abnormal white matter in chronic multiple sclerosis: imaging and histopathologic analysis. Arch Neurol (2009) 1.26
Altered diffusion tensor in multiple sclerosis normal-appearing brain tissue: cortical diffusion changes seem related to clinical deterioration. J Magn Reson Imaging (2006) 1.26
Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid Redox Signal (2007) 1.23
Whole-brain T1 mapping in multiple sclerosis: global changes of normal-appearing gray and white matter. Radiology (2006) 1.23
Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. Acta Neuropathol (2012) 1.22
Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis. Eur Radiol (2008) 1.22
Rapid quantification of myocardial fibrosis: a new macro-based automated analysis. Cell Oncol (Dordr) (2011) 1.22
The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol (2007) 1.20
Expression and distribution of id helix-loop-helix proteins in human astrocytic tumors. Glia (2002) 1.20
Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia. Epileptic Disord (2009) 1.20
Cognitive impairment in MS: impact of white matter integrity, gray matter volume, and lesions. Neurology (2013) 1.20
Tissue distribution and induction of human multidrug resistant protein 3. Lab Invest (2002) 1.19
Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy. Hum Gene Ther (2014) 1.19
Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases. Cancer (2012) 1.18
Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutières syndrome. Glia (2008) 1.18
Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia (2004) 1.17
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia (2006) 1.17
Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias. Epilepsia (2010) 1.17
Retinoic acid induces blood-brain barrier development. J Neurosci (2013) 1.17
Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology (2010) 1.16
Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain (2011) 1.16
TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. Gut (2011) 1.15
Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia (2012) 1.15
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. Epilepsia (2007) 1.14
Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiol Dis (2005) 1.14
Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. J Neuroimmunol (2003) 1.14
Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy. Curr Med Chem (2009) 1.14
Microglia activation in sepsis: a case-control study. J Neuroinflammation (2007) 1.13
A qualitative evaluation of a comprehensive self-management programme for COPD patients: effectiveness from the patients' perspective. Patient Educ Couns (2004) 1.13
Community based physiotherapeutic exercise in COPD self-management: a randomised controlled trial. Respir Med (2010) 1.13