Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMID 21710444)

Published in Eur Cell Mater on June 20, 2011

Authors

J V Stoyanov1, B Gantenbein-Ritter, A Bertolo, N Aebli, M Baur, M Alini, S Grad

Author Affiliations

1: AO Research Institute Davos, Clavadelerstrasse, Switzerland.

Associated clinical trials:

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease | NCT03692221

Articles citing this

Diversity of intervertebral disc cells: phenotype and function. J Anat (2012) 1.26

Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture. Eur Cell Mater (2011) 0.97

Organ culture bioreactors--platforms to study human intervertebral disc degeneration and regenerative therapy. Curr Stem Cell Res Ther (2015) 0.91

Novel immortal human cell lines reveal subpopulations in the nucleus pulposus. Arthritis Res Ther (2014) 0.89

Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapiesfor intervertebral disc degeneration. Bone Joint Res (2013) 0.87

Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs. Arthritis Res Ther (2014) 0.86

An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration. Eur Spine J (2014) 0.85

Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System. Stem Cells Int (2013) 0.84

Cell sources for nucleus pulposus regeneration. Eur Spine J (2013) 0.82

Effect of serum and oxygen concentration on gene expression and secretion of paracrine factors by mesenchymal stem cells. Int J Cell Biol (2014) 0.81

A modified aggregate culture for chondrogenesis of human adipose-derived stem cells genetically modified with growth and differentiation factor 5. Biores Open Access (2013) 0.80

Using notochordal cells of developmental origin to stimulate nucleus pulposus cells and bone marrow stromal cells for intervertebral disc regeneration. Eur Spine J (2013) 0.80

In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus. Tissue Eng Part A (2014) 0.80

Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration. Arthritis Res Ther (2015) 0.78

Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair. Am J Phys Med Rehabil (2013) 0.78

Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Curr Stem Cell Res Ther (2015) 0.77

Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells. J Zhejiang Univ Sci B (2016) 0.77

The generation and functional characterization of induced pluripotent stem cells from human intervertebral disc nucleus pulposus cells. Oncotarget (2017) 0.76

Role of growth differentiation factor-5 and bone morphogenetic protein type II receptor in the development of lumbar intervertebral disc degeneration. Int J Clin Exp Pathol (2015) 0.76

Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration. Oncotarget (2016) 0.76

Differentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia. Spine (Phila Pa 1976) (2015) 0.75

Mesenchymal stem cells: potential application in intervertebral disc regeneration. Transl Pediatr (2014) 0.75

Can notochordal cells promote bone marrow stromal cell potential for nucleus pulposus enrichment? A simplified in vitro system. Tissue Eng Part A (2014) 0.75

Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling. Sci Rep (2016) 0.75

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Stem Cell Res Ther (2016) 0.75

Effects of hypoxia on differentiation of menstrual blood stromal stem cells towards tenogenic cells in a co-culture system with Achilles tendon cells. Exp Ther Med (2017) 0.75

Articles by these authors

The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest (1996) 3.89

Gene targeting in plants. EMBO J (1988) 2.33

A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement. N Engl J Med (1997) 2.14

Aggrecan degradation in human intervertebral disc and articular cartilage. Biochem J (1997) 1.78

Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest (1995) 1.77

The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast. Genes Dev (1997) 1.70

Compression-induced changes in intervertebral disc properties in a rat tail model. Spine (Phila Pa 1976) (1999) 1.68

Climbing the Jaynes-Cummings ladder and observing its nonlinearity in a cavity QED system. Nature (2008) 1.55

The role of proteoglycans in aging, degeneration and repair of the intervertebral disc. Biochem Soc Trans (2002) 1.42

Two-qubit state tomography using a joint dispersive readout. Phys Rev Lett (2009) 1.37

Implementation of a Toffoli gate with superconducting circuits. Nature (2011) 1.35

Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation. J Invest Dermatol (1999) 1.32

Human genetics and human rights. Identifying the families of kidnapped children. Am J Forensic Med Pathol (1984) 1.27

Challenges and strategies in the repair of ruptured annulus fibrosus. Eur Cell Mater (2013) 1.27

Deterministic quantum teleportation with feed-forward in a solid state system. Nature (2013) 1.25

Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants. Eur J Cell Biol (1998) 1.20

Age-related changes in fibromodulin and lumican in human intervertebral discs. Spine (Phila Pa 1976) (1999) 1.19

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration. Osteoarthritis Cartilage (2009) 1.18

Differential modulation of epidermal keratinization in immortalized (HaCaT) and tumorigenic human skin keratinocytes (HaCaT-ras) by retinoic acid and extracellular Ca2+. Differentiation (1993) 1.14

The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration. Spine (Phila Pa 1976) (1996) 1.12

Role and regulation of RUNX2 in osteogenesis. Eur Cell Mater (2014) 1.12

In vitro and in vivo evaluation of a novel nanosize hydroxyapatite particles/poly(ester-urethane) composite scaffold for bone tissue engineering. Acta Biomater (2009) 1.11

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. Eur Cell Mater (2006) 1.11

Control and tomography of a three level superconducting artificial atom. Phys Rev Lett (2010) 1.08

Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment. J Med Genet (2007) 1.07

Family-based association test method: age of onset traits and covariates. Genet Epidemiol (2001) 1.04

Characterization of aggregating proteoglycans from the proliferative, maturing, hypertrophic, and calcifying zones of the cartilaginous physis. J Bone Joint Surg Am (1991) 1.01

A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells. Eur Cell Mater (2011) 1.00

Sulfated proteoglycans in the extracellular matrix of human breast tissues with infiltrating carcinoma. Int J Cancer (1993) 0.99

Engineered cartilage generated by nasal chondrocytes is responsive to physical forces resembling joint loading. Arthritis Rheum (2008) 0.99

Quantitative magnetic resonance imaging in the assessment of degenerative disc disease. Magn Reson Med (1998) 0.97

Engineering of bone using bone marrow stromal cells and a silicon-stabilized tricalcium phosphate bioceramic: evidence for a coupling between bone formation and scaffold resorption. Biomaterials (2006) 0.97

In vivo biocompatibility and vascularization of biodegradable porous polyurethane scaffolds for tissue engineering. Acta Biomater (2009) 0.96

Observation of resonant photon blockade at microwave frequencies using correlation function measurements. Phys Rev Lett (2011) 0.95

Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissues. Spine (Phila Pa 1976) (2001) 0.94

Platelet-released supernatant induces osteoblastic differentiation of human mesenchymal stem cells: potential role of BMP-2. Eur Cell Mater (2010) 0.94

Observation of two-mode squeezing in the microwave frequency domain. Phys Rev Lett (2011) 0.91

Regeneration of large bone defects in sheep using bone marrow stromal cells. J Tissue Eng Regen Med (2008) 0.91

HLA and IDDM predisposition: new aspects. Genet Epidemiol Suppl (1986) 0.91

Dressed collective qubit states and the Tavis-Cummings model in circuit QED. Phys Rev Lett (2009) 0.91

Docetaxel extravasation. Support Care Cancer (2001) 0.91

Income change at retirement. Soc Secur Bull (1990) 0.91

Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype. Dev Dyn (2000) 0.91

Nanohydroxyapatite/poly(ester urethane) scaffold for bone tissue engineering. Acta Biomater (2009) 0.90

Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols. Eur Cell Mater (2014) 0.90

Influence of human recombinant interferon-alpha2a (rhIFN-alpha2a) on altered lymphocyte subpopulations and monocytes in Behcet's disease. Rheumatology (Oxford) (2004) 0.90

3D scaffolds co-seeded with human endothelial progenitor and mesenchymal stem cells: evidence of prevascularisation within 7 days. Eur Cell Mater (2013) 0.90

Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets. Genet Epidemiol (1997) 0.89

The REV2 gene of Saccharomyces cerevisiae: cloning and DNA sequence. Curr Genet (1992) 0.89

Three-dimensional spheroids of adipose-derived mesenchymal stem cells are potent initiators of blood vessel formation in porous polyurethane scaffolds. Acta Biomater (2013) 0.89

Resolving vacuum fluctuations in an electrical circuit by measuring the Lamb shift. Science (2008) 0.88

Different response of articular chondrocyte subpopulations to surface motion. Osteoarthritis Cartilage (2007) 0.87

Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics. Eur Cell Mater (2014) 0.87

The clinical course of lung metastases from breast cancer. Klin Wochenschr (1988) 0.86

Valsartan: long-term efficacy and tolerability compared to lisinopril in elderly patients with essential hypertension. Clin Exp Hypertens (1997) 0.86

Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous gene pms1: molecular cloning and functional analysis. Genetics (1997) 0.86

Assessment of nutritional status at the time of diagnosis in patients treated for head and neck cancer. Eur Ann Otorhinolaryngol Head Neck Dis (2012) 0.85

VEGF levels in asthmatic airways do not correlate with plasma extravasation. Clin Exp Allergy (1999) 0.85

Quantum-to-classical transition in cavity quantum electrodynamics. Phys Rev Lett (2010) 0.84

Recombination fractions in the HLA system based on the data set 'provinces Françaises': indications of haplotype-specific recombination rates. Eur J Immunogenet (1994) 0.84

CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture. Eur Cell Mater (2014) 0.84

Gastric emptying of solids and liquids in obesity. Clin Investig (1993) 0.83

Collagen crosslinked N-telopeptides as markers for evaluating particulate osteolysis: a preliminary study. J Orthop Res (2000) 0.83

Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments. Eur Cell Mater (2012) 0.83

Enhancing inflammatory and chemotactic signals to regulate bone regeneration. Eur Cell Mater (2014) 0.82

Chondrogenesis of mesenchymal stem cells for cartilage tissue engineering. Histol Histopathol (2013) 0.82

Organotypic and epidermal-dermal co-cultures of normal human keratinocytes and dermal cells: Regulation of transforming growth factor alpha, beta1 and beta2 mRNA levels. Toxicol In Vitro (1994) 0.82

Cavity quantum electrodynamics with separate photon storage and qubit readout modes. Phys Rev Lett (2010) 0.82

[Tissue engineering of cartilage and bone : growth factors and signaling molecules]. Orthopade (2009) 0.82

[Propionic acidemia and sensorineural hearing loss: is there a connection at the molecular genetics level?]. HNO (2008) 0.81

Cardiovascular changes after pulmonary cement embolism: an experimental study in sheep. AJNR Am J Neuroradiol (2007) 0.81

Genetic polymorphisms of properdin factor B(Bf), the second component (C2), and the fourth component (C4) of complement in leprosy patients and healthy controls from Thailand. Immunobiology (1980) 0.80

Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent. Eur Cell Mater (2014) 0.80

Does predation risk influence habitat use by northern redbelly dace Phoxinus eos at different spatial scales? J Fish Biol (2009) 0.80

Degradable polymeric materials for osteosynthesis: tutorial. Eur Cell Mater (2008) 0.80

Release of ANP and fat oxidation in overweight persons during aerobic exercise in water. Int J Sports Med (2013) 0.80

Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater (2005) 0.79

Sliding motion modulates stiffness and friction coefficient at the surface of tissue engineered cartilage. Osteoarthritis Cartilage (2012) 0.79

Fructose malabsorption in children with recurrent abdominal pain: positive effects of dietary treatment. Klin Padiatr (2011) 0.79

Serum content of the C-propeptide of the cartilage molecule type II collagen in children. Clin Exp Rheumatol (1997) 0.79

Action of estradiol on epiphyseal growth plate chondrocytes. Calcif Tissue Int (2004) 0.78

[Effect of nonperiodic stimulation on the variability of visual evoked cortical potentials]. Dev Ophthalmol (1981) 0.78

In vitro and in vivo evaluation of the combination of cisplatin and its analogue carboplatin for platinum dose intensification in ovarian carcinoma. Cancer (1993) 0.78

[Sudden death caused by massive air embolism during respirator therapy in the newborn]. Helv Paediatr Acta (1979) 0.78

Platelet-rich plasma induces annulus fibrosus cell proliferation and matrix production. Eur Spine J (2014) 0.78

Evaluation of a new press-fit in situ setting composite porous scaffold for cancellous bone repair: towards a "surgeon-friendly" bone filler? Acta Biomater (2010) 0.77

Prostate carcinoma cell growth-inhibiting hydrogel supports axonal regeneration in vitro. Neurosci Lett (2013) 0.77

[Mitochondrial A1555G mutation. Molecular genetic diagnosis in sporadic cases of non-syndromic hearing impairment]. HNO (2004) 0.77

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins. Eur Cell Mater (2014) 0.77

Effects of hypobaric hypoxia on vascular endothelial growth factor and the acute phase response in subjects who are susceptible to high-altitude pulmonary oedema. Eur J Appl Physiol (2000) 0.77

Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors. J Med Chem (1998) 0.77

Prevention of thromboembolism with use of recombinant hirudin. Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement. J Bone Joint Surg Am (1997) 0.77

Promoting external inosculation of prevascularised tissue constructs by pre-cultivation in an angiogenic extracellular matrix. Eur Cell Mater (2010) 0.77