| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.
|
Org Lett
|
2011
|
1.08
|
|
2
|
In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.
|
Bioorg Med Chem
|
2011
|
0.95
|
|
3
|
Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties.
|
Org Biomol Chem
|
2007
|
0.95
|
|
4
|
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.
|
J Med Chem
|
2011
|
0.95
|
|
5
|
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
|
J Med Chem
|
2013
|
0.94
|
|
6
|
One-step, three-component synthesis of pyridines and 1,4-dihydropyridines with manifold medicinal utility.
|
Org Lett
|
2006
|
0.93
|
|
7
|
One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomponent reaction of malononitrile with aldehydes and thiols.
|
J Org Chem
|
2007
|
0.89
|
|
8
|
Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells.
|
ChemMedChem
|
2012
|
0.87
|
|
9
|
Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system.
|
Tetrahedron Lett
|
2006
|
0.87
|
|
10
|
Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.
|
J Org Chem
|
2009
|
0.87
|
|
11
|
Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity.
|
Bioorg Med Chem Lett
|
2011
|
0.82
|
|
12
|
Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.
|
J Med Chem
|
2015
|
0.77
|
|
13
|
Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones.
|
Chem Commun (Camb)
|
2013
|
0.76
|
|
14
|
Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification.
|
J Liposome Res
|
2014
|
0.75
|
|
15
|
Aryliodine (III) Diacetates as Substrates for Pd-Ag Catalyzed Arylation of Alkenes.
|
Tetrahedron Lett
|
2011
|
0.75
|
|
16
|
Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.
|
Tetrahedron Lett
|
2011
|
0.75
|