Matrix elastin: a promising biomarker for chronic obstructive pulmonary disease.

PubWeight™: 0.93‹?›

🔗 View Article (PMID 21757624)

Published in Am J Respir Crit Care Med on September 15, 2011

Authors

Gerard M Turino1, Shuren Ma, Yong Y Lin, Jerome O Cantor, Maurizio Luisetti

Author Affiliations

1: St. Luke’s-Roosevelt Hospital, Pulmonary Medicine, 1000 Tenth Avenue, New York, New York 10019, USA. gmt1@columbia.edu

Associated clinical trials:

The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation | NCT03285100

Articles by these authors

Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood (2009) 2.79

Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med (2009) 1.58

Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm. Am J Respir Crit Care Med (2015) 1.52

The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease? Mod Pathol (2006) 1.49

The effect of secondhand smoke exposure on markers of elastin degradation. Chest (2011) 1.41

Hyaluronan in respiratory injury and repair. Am J Respir Crit Care Med (2003) 1.23

Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med (2010) 1.21

Pulmonary alveolar proteinosis: diagnostic and therapeutic challenges. Multidiscip Respir Med (2012) 1.18

Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med (2010) 1.10

Complement receptor 1 gene polymorphisms are associated with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2003) 1.10

Laboratory diagnosis of alpha1-antitrypsin deficiency. Transl Res (2007) 1.08

α₁-Antitrypsin level and pheno/genotypes. Chest (2013) 1.07

EGFR and KRAS mutational profiling in fresh non-small cell lung cancer (NSCLC) cells. J Cancer Res Clin Oncol (2013) 1.02

Targeting EGFR in non-small-cell lung cancer: lessons, experiences, strategies. Respir Med (2011) 1.02

Measurements of desmosine and isodesmosine by mass spectrometry in COPD. Chest (2007) 1.02

The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum. Proc Natl Acad Sci U S A (2003) 1.00

SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations. Clin Chem (2008) 1.00

Successful whole lung lavage in pulmonary alveolar proteinosis secondary to lysinuric protein intolerance: a case report. Orphanet J Rare Dis (2007) 0.98

Serum levels and genotype distribution of α1-antitrypsin in the general population. Thorax (2012) 0.98

Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet (2013) 0.97

Assessment and management of pulmonary alveolar proteinosis in a reference center. Orphanet J Rare Dis (2013) 0.97

HLA and sarcoidosis: new pathogenetic insights. Sarcoidosis Vasc Diffuse Lung Dis (2002) 0.97

Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOF. J Proteome Res (2007) 0.96

Validation of a rapid, simple method to measure alpha1-antitrypsin in human dried blood spots. Clin Chem (2006) 0.95

Circulating alpha1-antitrypsin in the general population: determinants and association with lung function. Respir Res (2008) 0.94

Capillary electrophoresis with laser-induced fluorescence detection as a novel sensitive approach for the analysis of desmosines in real samples. Electrophoresis (2004) 0.90

Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report. Orphanet J Rare Dis (2009) 0.90

Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema. Exp Lung Res (2005) 0.89

Incomplete expression of epithelial-mesenchymal transition markers in idiopathic pulmonary fibrosis. Pathol Res Pract (2011) 0.88

A novel method for rapid genotypic identification of alpha 1-antitrypsin variants. Diagn Mol Pathol (2004) 0.87

Complement receptor 1 gene polymorphisms in sarcoidosis. Am J Respir Cell Mol Biol (2002) 0.87

Proteomics-based diagnosis of chronic obstructive pulmonary disease: the hunt for new markers. Expert Rev Proteomics (2008) 0.86

Short-term cigarette smoke exposure potentiates endotoxin-induced pulmonary inflammation. Exp Lung Res (2007) 0.86

In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages. Orphanet J Rare Dis (2010) 0.86

C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants. Transl Res (2011) 0.85

Expression of receptor for advanced glycation end products in sarcoid granulomas. Am J Respir Crit Care Med (2006) 0.85

Alpha1-antitrypsin deficiency - diagnostic testing and disease awareness in Germany and Italy. Respir Med (2013) 0.85

Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury. Exp Lung Res (2006) 0.84

Identification of a novel alpha1-antitrypsin null variant (Q0Cairo). Diagn Mol Pathol (2005) 0.84

The rapid FEV(1) decline in chronic obstructive pulmonary disease is associated with predominant emphysema: a longitudinal study. COPD (2012) 0.84

Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.83

Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS. Int J Mol Sci (2012) 0.83

Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency. Respir Res (2005) 0.83

Phosphoramidon, an endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury. Exp Lung Res (2008) 0.83

Characterization of peptide fragments from lung elastin degradation in chronic obstructive pulmonary disease. Exp Lung Res (2010) 0.83

Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy? Lung (2010) 0.83

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization. PLoS One (2012) 0.83

Plasma sRAGE and N-(carboxymethyl) lysine in patients with CHF and/or COPD. Eur J Clin Invest (2013) 0.83

Clinical phenotypes of Italian and Spanish patients with α1-antitrypsin deficiency. Eur Respir J (2012) 0.82

NOD2/CARD15 gene polymorphisms in idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis (2005) 0.81

Progress in the methodological strategies for the detection in real samples of desmosine and isodesmosine, two biological markers of elastin degradation. J Sep Sci (2007) 0.81

SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort. PLoS One (2012) 0.81

Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency. Orphanet J Rare Dis (2012) 0.80

Factors influencing oxidative imbalance in pulmonary fibrosis: an immunohistochemical study. Pulm Med (2011) 0.80

Attenuating effect of taurine on lipopolysaccharide-induced acute lung injury in hamsters. Pharmacol Res (2009) 0.80

Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke. Int J Chron Obstruct Pulmon Dis (2008) 0.80

Clinical utility gene card for: α-1-antitrypsin deficiency. Eur J Hum Genet (2011) 0.80

Endothelin-1 potentiates smoke-induced acute lung inflammation. Exp Lung Res (2008) 0.80

Early response of gene clusters is associated with mouse lung resistance or sensitivity to cigarette smoke. Am J Physiol Lung Cell Mol Physiol (2008) 0.80

The effect of tiotropium therapy on markers of elastin degradation in COPD. Respir Res (2009) 0.79

Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to alpha1-antitrypsin deficiency. J Proteomics (2008) 0.79

Elastin degradation: an effective biomarker in COPD. COPD (2012) 0.78

Short-term cigarette smoke exposure predisposes the lung to secondary injury. Lung (2007) 0.78

Alpha-1 antitrypsin augmentation therapy and biomarkers of elastin degradation. COPD (2013) 0.78

[AGE receptor: a novel pro-inflammatory pathway for chronic respiratory disorders?]. Recenti Prog Med (2008) 0.78

Subclinical hyperthyroidism increases risk of coronary heart disease events in type 2 diabetes mellitus. Endocrine (2014) 0.78

Impaired phagocytosis in macrophages from patients affected by lysinuric protein intolerance. Mol Genet Metab (2012) 0.77

The Ratio of Free to Bound Desmosine and Isodesmosine May Reflect Emphysematous Changes in COPD. Lung (2015) 0.77

Advances in proteomic techniques for biomarker discovery in COPD. Expert Rev Clin Immunol (2011) 0.77

Interaction between mannosylated lipoarabinomannan and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin influences dendritic cells maturation and T cell immunity. Cell Immunol (2011) 0.77

Long-term variability of desmosine/isodesmosine as biomarker in alpha-1-antritrypsin deficiency-related COPD. COPD (2011) 0.77

Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: a critical review of the state-of-the-art. Electrophoresis (2005) 0.77

Desmosine and Isodesmosine as a Novel Biomarker for Pulmonary Arterial Hypertension: A Pilot Study. Am J Ther (2015) 0.76

CR1 gene polymorphism in Finland. Respir Med (2005) 0.75

Synchronous lung cancers: when same histological types feature different molecular profiles and response phenotypes. J Cancer (2011) 0.75

You may say that I ain't free--but it don't worry me. Am J Respir Crit Care Med (2003) 0.75

Synergistic effect of hydrogen peroxide and elastase on elastic fiber injury in vitro. Exp Biol Med (Maywood) (2006) 0.75

Comment on 'CFTR gene mutations in sarcoidosis'. Eur J Hum Genet (2003) 0.75

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency. Respir Res (2014) 0.75

The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis. Orphanet J Rare Dis (2013) 0.75

Stable deuterium internal standard for the isotope-dilution LC-MS/MS analysis of elastin degradation. Anal Biochem (2013) 0.75

SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase. Respir Res (2005) 0.75

Analysis of clinical characteristics of pancreatic carcinoma in northern China. Pancreas (2010) 0.75

The role of desmosines as biomarkers for chronic obstructive pulmonary disease. Expert Rev Respir Med (2013) 0.75

Clinical efficacy of endoscopic pancreatic drainage for pain relief with malignant pancreatic duct obstruction. Asian Pac J Cancer Prev (2014) 0.75

New assumptions about oxidative processes involved in steroid hormone biosynthesis: is the role of cytochrome P-450-activated dioxygen limited to hydroxylation reactions or are dioxygen insertion reactions also possible? J Steroid Biochem Mol Biol (2005) 0.75

Total synthesis of COPD biomarker desmosine that crosslinks elastin. Chem Commun (Camb) (2012) 0.75

From micellar electrokinetic chromatography to liquid chromatography-mass spectrometry: revisiting the way of analyzing human fluids for the search of desmosines, putative biomarkers of chronic obstructive pulmonary disease. Electrophoresis (2013) 0.75

Micellar electrokinetic chromatography with laser induced detection and liquid chromatography tandem mass-spectrometry-based desmosine assays in urine of patients with Chronic Obstructive Pulmonary Disease: a comparative analysis. J Chromatogr A (2012) 0.75

Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine. Org Biomol Chem (2014) 0.75