Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMC 3359902)

Published in Am J Respir Cell Mol Biol on July 28, 2011

Authors

Elle C Roberson1, Jane E Tully, Amy S Guala, Jessica N Reiss, Karolyn E Godburn, Derek A Pociask, John F Alcorn, David W H Riches, Oliver Dienz, Yvonne M W Janssen-Heininger, Vikas Anathy

Author Affiliations

1: Department of Pathology, University of Vermont, Burlington, VT 05405, USA.

Articles citing this

IL-22 is essential for lung epithelial repair following influenza infection. Am J Pathol (2013) 1.26

NOD1 and NOD2 signalling links ER stress with inflammation. Nature (2016) 1.10

ER stress, autophagy, and RNA viruses. Front Microbiol (2014) 1.08

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife (2015) 0.93

Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis. J Allergy Clin Immunol (2012) 0.91

Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis. Respir Res (2013) 0.91

Retracted Mutant surfactant A2 proteins associated with familial pulmonary fibrosis and lung cancer induce TGF-β1 secretion. Proc Natl Acad Sci U S A (2012) 0.89

The UPR and lung disease. Semin Immunopathol (2013) 0.86

Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and currently available drugs. J Prev Med Hyg (2014) 0.86

Endoplasmic reticulum stress and the related signaling networks in severe asthma. Allergy Asthma Immunol Res (2014) 0.83

Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation. J Biol Chem (2014) 0.83

Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract. Curr Opin Virol (2012) 0.82

Proapoptotic activities of protein disulfide isomerase (PDI) and PDIA3 protein, a role of the Bcl-2 protein Bak. J Biol Chem (2015) 0.81

Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway. Cell Rep (2015) 0.80

A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula. Evid Based Complement Alternat Med (2013) 0.80

Kinetic analysis of the immunity in a pregnant patient infected with avian influenza H7N9. Int J Clin Exp Med (2014) 0.79

Retracted Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells. J Biol Chem (2013) 0.78

Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors. Mem Inst Oswaldo Cruz (2013) 0.78

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection. Am J Pathol (2017) 0.78

Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Sci Rep (2017) 0.76

Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity. PLoS Pathog (2017) 0.75

NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation. DNA Cell Biol (2016) 0.75

IL-6 ameliorates acute lung injury in influenza virus infection. Sci Rep (2017) 0.75

Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis. J Zhejiang Univ Sci B (2017) 0.75

Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition. MBio (2016) 0.75

NOD1 and NOD2: Beyond Peptidoglycan Sensing. Trends Immunol (2017) 0.75

SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection. Sci Rep (2017) 0.75

Articles cited by this

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45

Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature (2009) 11.34

Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer (2009) 9.33

TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol (2008) 8.95

Orchestrating the unfolded protein response in health and disease. J Clin Invest (2002) 7.60

From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17

Innate immunity to virus infection. Immunol Rev (2009) 7.04

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45

The pathology of influenza virus infections. Annu Rev Pathol (2008) 5.37

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell (2009) 4.98

Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med (2009) 4.37

Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein. Virology (2003) 3.77

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem (2001) 3.46

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med (2010) 3.44

Signal integration via PKR. Sci STKE (2001) 3.17

Infection of human airway epithelium by human and avian strains of influenza a virus. J Virol (2006) 3.02

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene (1999) 2.66

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis (2000) 2.63

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J (1998) 2.56

Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol (2002) 2.30

Epithelial decision makers: in search of the 'epimmunome'. Nat Immunol (2010) 2.19

Influenza virus neuraminidase activates latent transforming growth factor beta. J Virol (1996) 2.17

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci (2008) 1.60

Role of apoptosis and cytokines in influenza virus morbidity. FEMS Microbiol Rev (2004) 1.49

Clinical pathological characteristics and management of acute respiratory distress syndrome resulting from influenza A (H1N1) virus. South Med J (2010) 1.48

Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis. PLoS Pathog (2010) 1.44

Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release. J Gen Virol (2003) 1.30

The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. J Virol (2006) 1.28

Consequences of ERp57 deletion on oxidative folding of obligate and facultative clients of the calnexin cycle. J Biol Chem (2006) 1.27

Transforming growth factor-beta: a mediator of cell regulation in acute respiratory distress syndrome. Crit Care Med (2003) 1.26

Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol (2008) 1.26

c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3. Am J Respir Cell Mol Biol (2010) 1.11

Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase. Mol Cell Biol (2004) 0.99

Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J Virol (2010) 0.98

Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells. Am J Respir Cell Mol Biol (2010) 0.98

Quantitative proteome profiling of respiratory virus-infected lung epithelial cells. J Proteomics (2010) 0.96

Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome. J Immunol (2009) 0.90

Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus. Virus Res (2008) 0.89

Articles by these authors

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol (2008) 3.42

Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity (2009) 3.33

Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity (2013) 2.61

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A (2006) 2.51

Critical role of IL-17RA in immunopathology of influenza infection. J Immunol (2009) 2.51

Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc Natl Acad Sci U S A (2004) 2.19

Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity (2011) 2.15

Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol (2010) 2.04

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood (2008) 2.02

A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. J Immunol (2003) 1.99

ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J Cell Sci (2005) 1.99

Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol (2009) 1.93

Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol (2006) 1.84

NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol (2004) 1.73

Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid Redox Signal (2006) 1.67

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol (2002) 1.66

Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. Am J Respir Crit Care Med (2007) 1.63

Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2004) 1.62

Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J Immunol (2003) 1.61

IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One (2011) 1.61

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci (2008) 1.60

Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J (2004) 1.53

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49

Vitamin D and asthma. Am J Respir Crit Care Med (2011) 1.44

Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol (2008) 1.44

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas. J Cell Biol (2009) 1.42

Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med (2014) 1.40

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med (2008) 1.40

Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol (2010) 1.33

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control. Proc Am Thorac Soc (2009) 1.31

Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways. Circ Res (2009) 1.31

Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina. J Exp Med (2010) 1.29

Pseudomonas aeruginosa elastase degrades surfactant proteins A and D. Am J Respir Cell Mol Biol (2003) 1.28

Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. Am J Respir Crit Care Med (2007) 1.28

Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med (2012) 1.28

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization. Biochim Biophys Acta (2006) 1.27

Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest (2010) 1.27

Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol (2011) 1.27

c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.26

IL-22 is essential for lung epithelial repair following influenza infection. Am J Pathol (2013) 1.26

Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells. J Immunol (2008) 1.25

Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease. Am J Respir Cell Mol Biol (2006) 1.25

Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells. Antioxid Redox Signal (2006) 1.22

Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner. J Immunol (2010) 1.21

Susceptibility to asbestos-induced and transforming growth factor-beta1-induced fibroproliferative lung disease in two strains of mice. Am J Respir Cell Mol Biol (2002) 1.19

Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways. Am J Physiol Cell Physiol (2002) 1.19

PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood (2010) 1.18

IL-6 is required for airway mucus production induced by inhaled fungal allergens. J Immunol (2009) 1.17

TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am J Respir Cell Mol Biol (2005) 1.17

Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation. Am J Physiol Cell Physiol (2005) 1.17

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells. Arthritis Res Ther (2011) 1.15

Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J Immunol (2008) 1.15

T(H)17 cells in asthma and inflammation. Biochim Biophys Acta (2011) 1.14

Influenza A exacerbates Staphylococcus aureus pneumonia by attenuating IL-1β production in mice. J Immunol (2013) 1.14

Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol (2008) 1.13

Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol (2014) 1.12

Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production. J Infect Dis (2013) 1.11

IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal. J Leukoc Biol (2004) 1.11

c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3. Am J Respir Cell Mol Biol (2010) 1.11

Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation. Am J Respir Cell Mol Biol (2010) 1.10

Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen. Am J Respir Cell Mol Biol (2010) 1.08

Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia. J Exp Med (2013) 1.08

Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol (2011) 1.06

Lung dendritic cells at the innate-adaptive immune interface. J Leukoc Biol (2011) 1.03

Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp (2011) 1.03

NF-kappaB activation pathways induced by T cell costimulation. FASEB J (2003) 1.03

Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domain. J Immunol (2002) 1.02

Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation. Am J Respir Cell Mol Biol (2006) 1.01

Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal (2011) 1.01

Effects of torsion on intervertebral disc gene expression and biomechanics, using a rat tail model. Spine (Phila Pa 1976) (2011) 1.00

Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol (2011) 1.00

Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Mol Cell Biochem (2002) 1.00

Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes. J Allergy Clin Immunol (2012) 1.00

Obesity impairs apoptotic cell clearance in asthma. J Allergy Clin Immunol (2012) 0.98

Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis. Mol Cell Biol (2012) 0.97

Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ. Methods Enzymol (2010) 0.96

Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol (2009) 0.95

Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling. J Immunol (2013) 0.95

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J (2013) 0.95

Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression. Mol Cell Biol (2007) 0.93