A multicentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMID 21834921)

Published in Acta Ophthalmol on August 11, 2011

Authors

Françoise Brignole-Baudouin1, Christophe Baudouin, Pasquale Aragona, Maurizio Rolando, Marc Labetoulle, Pierre Jean Pisella, Stefano Barabino, Raphaele Siou-Mermet, Catherine Creuzot-Garcher

Author Affiliations

1: Department of Toxicology, Paris Descartes University, Paris, France. francoise.brignole@inserm.fr

Articles citing this

Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders. Clin Interv Aging (2013) 1.12

A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction. Clin Interv Aging (2013) 1.07

Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids. Clin Interv Aging (2013) 1.01

Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond) (2014) 1.00

Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. Invest Ophthalmol Vis Sci (2013) 0.99

Effect of a Mediterranean dietary pattern and vitamin D levels on Dry Eye syndrome. Cornea (2014) 0.96

Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study. Clin Interv Aging (2016) 0.87

HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface disease. Exp Eye Res (2013) 0.84

Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. Prostaglandins Leukot Essent Fatty Acids (2012) 0.83

A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids. Mol Vis (2015) 0.80

Essential fatty acids in the treatment of dry eye syndrome: A myth or reality? Saudi J Ophthalmol (2014) 0.80

Therapeutic Strategies to Treat Dry Eye in an Aging Population. Drugs Aging (2015) 0.79

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research. Invest Ophthalmol Vis Sci (2017) 0.78

Ocular Surface and Tear Film Changes in Older Women Working with Computers. Biomed Res Int (2015) 0.78

A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease. Ophthalmology (2016) 0.76

Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease-A Prospective, Multicenter Noninterventional Study. J Ocul Pharmacol Ther (2015) 0.75

Effects of adjuvant omega-3 fatty acid supplementation on dry eye syndrome following cataract surgery: A randomized clinical trial. J Curr Ophthalmol (2016) 0.75

Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. J Ocul Pharmacol Ther (2013) 0.75

The self-reported clinical practice behaviors of Australian optometrists as related to smoking, diet and nutritional supplementation. PLoS One (2015) 0.75

Articles by these authors

Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea (2006) 3.18

Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome. Proc Natl Acad Sci U S A (2006) 3.11

The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci (2011) 2.66

Relationship between baseline clinical data and microbiologic spectrum in 100 patients with acute postcataract endophthalmitis. Retina (2012) 2.12

The ocular surface of glaucoma patients treated over the long term expresses inflammatory markers related to both T-helper 1 and T-helper 2 pathways. Ophthalmology (2007) 2.10

Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol (2011) 1.94

Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch Ophthalmol (2008) 1.85

Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest Ophthalmol Vis Sci (2004) 1.70

Anterior chamber paracentesis in patients with acute elevation of intraocular pressure. Graefes Arch Clin Exp Ophthalmol (2006) 1.64

Amniotic membrane transplantation in a case of ligneous conjunctivitis. Am J Ophthalmol (2004) 1.63

In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci (2005) 1.63

Comparison of face-down and seated position after idiopathic macular hole surgery: a randomized clinical trial. Am J Ophthalmol (2008) 1.61

The controlled-environment chamber: a new mouse model of dry eye. Invest Ophthalmol Vis Sci (2005) 1.55

Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term. Ophthalmology (2004) 1.46

The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease. Invest Ophthalmol Vis Sci (2011) 1.46

Th1 and Th2 responses on the ocular surface in uveitis identified by CCR4 and CCR5 conjunctival expression. Am J Ophthalmol (2007) 1.41

Comparison of toxicological profiles of benzalkonium chloride and polyquaternium-1: an experimental study. J Ocul Pharmacol Ther (2006) 1.31

In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line. Curr Eye Res (2008) 1.29

In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res (2013) 1.27

Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride: early detection of toxic damage. Invest Ophthalmol Vis Sci (2009) 1.25

Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf (2013) 1.25

In vivo corneal confocal microscopy comparison of intralase femtosecond laser and mechanical microkeratome for laser in situ keratomileusis. Invest Ophthalmol Vis Sci (2006) 1.23

Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea (2003) 1.23

In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci (2005) 1.22

Novel expression and characterization of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1) by conjunctival cells. Invest Ophthalmol Vis Sci (2005) 1.22

Contribution of in vivo confocal microscopy to the diagnosis and management of infectious keratitis. Ocul Surf (2009) 1.21

In vivo confocal microscopy study of blebs after filtering surgery. Ophthalmology (2005) 1.20

Report of the TFOS/ARVO Symposium on global treatments for dry eye disease: an unmet need. Ocul Surf (2012) 1.19

A randomized controlled trial of alleviated positioning after small macular hole surgery. Ophthalmology (2010) 1.19

Prevalence of refractive error in Europe: the European Eye Epidemiology (E(3)) Consortium. Eur J Epidemiol (2015) 1.18

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. J Virol (2011) 1.18

Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts. J Virol (2006) 1.17

Very late antigen 1 blockade markedly promotes survival of corneal allografts. Arch Ophthalmol (2007) 1.17

Prospective, unmasked evaluation of the iStent® inject system for open-angle glaucoma: synergy trial. Adv Ther (2014) 1.15

Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci (2011) 1.15

In vitro effects of preserved and unpreserved antiglaucoma drugs on apoptotic marker expression by human trabecular cells. Graefes Arch Clin Exp Ophthalmol (2003) 1.15

Dry eye disease, dry eye symptoms and depression: the Beijing Eye Study. Br J Ophthalmol (2013) 1.15

Macular hole surgery and cataract extraction: combined vs consecutive surgery. Am J Ophthalmol (2010) 1.14

Measurement of health-related quality of life with glaucoma: validation of the Glau-QoL 36-item questionnaire. Acta Ophthalmol (2007) 1.11

Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells. Mol Ther (2011) 1.11

Efficacy and safety of preservative-free latanoprost eyedrops, compared with BAK-preserved latanoprost in patients with ocular hypertension or glaucoma. Br J Ophthalmol (2012) 1.10

Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off. Am J Ophthalmol (2011) 1.10

Incidence of retinal detachment after macular surgery: a retrospective study of 634 cases. Br J Ophthalmol (2007) 1.09

Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations. Invest Ophthalmol Vis Sci (2013) 1.09

CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1/ T(H)2 in ocular surface disorders. J Allergy Clin Immunol (2005) 1.09

Flow cytometry in conjunctival impression cytology: a new tool for exploring ocular surface pathologies. Exp Eye Res (2004) 1.08

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina. Curr Eye Res (2007) 1.08

New tools for the evaluation of toxic ocular surface changes in the rat. Invest Ophthalmol Vis Sci (2007) 1.08

Randomized, phase III study comparing osmoprotective carboxymethylcellulose with sodium hyaluronate in dry eye disease. Eur J Ophthalmol (2012) 1.06

History and future of the European Board of Ophthalmology Diploma examination. Acta Ophthalmol (2012) 1.06

Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system. Br J Ophthalmol (2011) 1.06

Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes. Cornea (2005) 1.05

Tear film aberration dynamics and vision-related quality of life in patients with dry eye disease. Ophthalmology (2012) 1.04

Comparative anatomy of laboratory animal corneas with a new-generation high-resolution in vivo confocal microscope. Curr Eye Res (2006) 1.04

Corneal endothelial cell changes after trabeculectomy and deep sclerectomy. J Glaucoma (2007) 1.03

Corneal epithelial proliferation and thickness in a mouse model of dry eye. Exp Eye Res (2009) 1.02

The impact of dry eye disease on visual performance while driving. Am J Ophthalmol (2013) 1.02

Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Graefes Arch Clin Exp Ophthalmol (2004) 1.02

In vivo confocal microscopy in fungal keratitis. Br J Ophthalmol (2006) 1.01

In vivo confocal microscopy and ex vivo flow cytometry: new tools for assessing ocular inflammation applied to rabbit lipopolysaccharide-induced conjunctivitis. Mol Vis (2006) 1.01

Evaluation of adding item-response theory analysis for evaluation of the European Board of Ophthalmology Diploma examination. Acta Ophthalmol (2013) 1.00

Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. Curr Eye Res (2007) 1.00

Measurement of treatment compliance using a medical device for glaucoma patients associated with intraocular pressure control: a survey. Clin Ophthalmol (2010) 1.00

Effect of the ocular microenvironment in regulating corneal dendritic cell maturation. Arch Ophthalmol (2007) 0.99

ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci (2008) 0.99

HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons. PLoS Pathog (2012) 0.98

Herpesvirus tegument protein pUL37 interacts with dystonin/BPAG1 to promote capsid transport on microtubules during egress. J Virol (2012) 0.97

Prospective, multicenter demographic and epidemiological study on vernal keratoconjunctivitis: a glimpse of ocular surface in Italian population. Ophthalmic Epidemiol (2009) 0.96

The relationship between subbasal nerve morphology and corneal sensation in ocular surface disease. Invest Ophthalmol Vis Sci (2012) 0.96

Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Mol Vis (2012) 0.96

Cornea in Marfan disease: Orbscan and in vivo confocal microscopy analysis. Invest Ophthalmol Vis Sci (2002) 0.96

Direct epithelial-stromal interaction in corneal wound healing: Role of EMMPRIN/CD147 in MMPs induction and beyond. Prog Retin Eye Res (2008) 0.95

Occludin gene expression as an early in vitro sign for mild eye irritation assessment. Toxicol In Vitro (2009) 0.95

An in vivo confocal microscopy and impression cytology evaluation of pterygium activity. Cornea (2010) 0.94

Influence of sutureless 23-gauge sclerotomy architecture on postoperative intraocular pressure decrease: results of a multivariate analysis. Graefes Arch Clin Exp Ophthalmol (2012) 0.94

Epithelial basement membrane dystrophy: evaluation with the HRT II Rostock Cornea Module. Ophthalmology (2006) 0.94

Influence of corneal biomechanical properties on surgically induced astigmatism in cataract surgery. J Cataract Refract Surg (2013) 0.94

Nutritional, lifestyle and environmental factors in ocular hypertension and primary open-angle glaucoma: an exploratory case-control study. Acta Ophthalmol (2012) 0.94

LPS-stimulated inflammation and apoptosis in corneal injury models. Mol Vis (2007) 0.93

Differential mechanisms of conjunctival cell death induction by ultraviolet irradiation and benzalkonium chloride. Invest Ophthalmol Vis Sci (2006) 0.93

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits. PLoS One (2012) 0.93

In vitro and in vivo comparative toxicological study of a new preservative-free latanoprost formulation. Invest Ophthalmol Vis Sci (2012) 0.92

Pathways of corneal and ocular surface inflammation: a perspective from the cullen symposium. Ocul Surf (2005) 0.92

The international workshop on meibomian gland dysfunction: report of the clinical trials subcommittee. Invest Ophthalmol Vis Sci (2011) 0.92

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. Invest Ophthalmol Vis Sci (2009) 0.91

Fusarium keratitis and endophthalmitis associated with lens contact wear. Int Ophthalmol (2009) 0.91

Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study. PLoS One (2012) 0.91

EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease. Am J Pathol (2011) 0.91

Live conjunctiva-associated lymphoid tissue analysis in rabbit under inflammatory stimuli using in vivo confocal microscopy. Invest Ophthalmol Vis Sci (2009) 0.91

Amniotic membrane transplantation elicits goblet cell repopulation after conjunctival reconstruction in a case of severe ocular cicatricial pemphigoid. Acta Ophthalmol Scand (2003) 0.90

Tear film osmolarity in patients treated for glaucoma or ocular hypertension. Cornea (2012) 0.90

Reduced in vivo ocular surface toxicity with polyquad-preserved travoprost versus benzalkonium-preserved travoprost or latanoprost ophthalmic solutions. Ophthalmic Res (2012) 0.90

Long-term outcome of idiopathic macular hole surgery. Am J Ophthalmol (2009) 0.90

Assessment of induced corneal hypoxia in diabetic patients. Cornea (2002) 0.90