Published in Eur J Med Chem on August 04, 2011
The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm (2012) 1.30
An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model. J Proteomics (2012) 0.90
A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies. Invest New Drugs (2013) 0.89
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol (2013) 0.88
Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Mol Cancer Ther (2012) 0.87
Src signaling pathways in prostate cancer. Cancer Metastasis Rev (2014) 0.86
4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities. Daru (2012) 0.84
Synthesis and antidiabetic evaluation of benzenesulfonamide derivatives. Iran J Pharm Res (2013) 0.81
2-(1,3-Benzothiazol-2-ylsulfanyl)-N-(2-methylphenyl)acetamide. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
Crystal structure of 2-cyano-N-(furan-2-ylmeth-yl)-3-(3-nitro-phen-yl)propanamide. Acta Crystallogr E Crystallogr Commun (2015) 0.75
Crystal structure of 2-cyano-N-(furan-2-ylmeth-yl)acetamide. Acta Crystallogr E Crystallogr Commun (2015) 0.75
Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia. Blood (2017) 0.75
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03
Design, synthesis, and biological evaluation of substituted 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles as selective COX-2 inhibitors. Bioorg Med Chem (2005) 1.89
Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles. Bioorg Med Chem Lett (2004) 1.82
Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones. Bioorg Med Chem Lett (2005) 1.64
Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring. Eur J Med Chem (2007) 1.40
Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles. Bioorg Med Chem Lett (2005) 1.36
Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation. Eur J Med Chem (2008) 1.25
SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway. J Biol Chem (2009) 1.19
Structural features of new quinolones and relationship to antibacterial activity against Gram-positive bacteria. Mini Rev Med Chem (2006) 1.19
Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase. Proc Natl Acad Sci U S A (2003) 1.18
2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents. Bioorg Med Chem Lett (2007) 1.17
Phytochemical investigation and anti-inflammatory activity of aerial parts of Stachys byzanthina C. Koch. J Ethnopharmacol (2005) 1.16
SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition. Cancer Res (2006) 1.16
Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides. Biol Pharm Bull (2006) 1.16
Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease. Circulation (2004) 1.16
Umbelliprenin from Ferula persica roots inhibits the red pigment production in Serratia marcescens. Z Naturforsch C (2005) 1.14
Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biol (2013) 1.13
Antidiabetic effect of Phlomis anisodonta: effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Pharmacol Res (2007) 1.13
Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain binding. J Med Chem (2004) 1.12
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists. Bioorg Med Chem (2003) 1.12
Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents. Eur J Med Chem (2010) 1.11
Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew Chem Int Ed Engl (2011) 1.11
Bioactive compounds of the volatile oil of Dracocephalum kotschyi. Z Naturforsch C (2008) 1.11
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists. Bioorg Med Chem Lett (2005) 1.10
Design and synthesis of new 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles as anticonvulsant agents. Chem Pharm Bull (Tokyo) (2008) 1.09
Stereoselective synthesis and in vitro antifungal evaluation of (E)- and (Z)-imidazolylchromanone oxime ethers. Arch Pharm (Weinheim) (2002) 1.08
Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family. Biomed Pharmacother (2011) 1.04
Stereoselective synthesis and antifungal activity of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers. Bioorg Med Chem (2004) 1.04
Synthesis and analgesic activity of N-Arylhydrazone derivatives of mefenamic acid. J Pharm Pharm Sci (2005) 1.03
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. BMC Cancer (2009) 0.99
Antiproliferative activity of flavonoids: influence of the sequential methoxylation state of the flavonoid structure. Phytother Res (2011) 0.99
miRNAs expressed differently in cancer stem cells and cancer cells of human gastric cancer cell line MKN-45. Cell Biochem Funct (2012) 0.97
Structural basis for domain-domain communication in a protein tyrosine kinase, the C-terminal Src kinase. J Mol Biol (2006) 0.97
Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone. Daru (2013) 0.97
Anti-Helicobacter pylori activity and Structure-Activity Relationship study of 2-Alkylthio-5-(nitroaryl)-1,3,4-thiadiazole Derivatives. Iran J Pharm Res (2013) 0.96
Total synthesis and in vitro-antifungal activity of (+/-)-2-methoxytetradecanoic Acid. Arch Pharm (Weinheim) (2004) 0.96
Synthesis of carbon-14 analogue of 1,5 diaryl-5-[14C]-1,2,3-triazoles. Appl Radiat Isot (2004) 0.95
Synthesis and biological evaluation of fatty acyl ester derivatives of (-)-2',3'-dideoxy-3'-thiacytidine. J Med Chem (2012) 0.95
Asymmetrical 2,6-bis(benzylidene)cyclohexanones: Synthesis, cytotoxic activity and QSAR study. Eur J Med Chem (2012) 0.95
Synthesis and cytotoxic properties of novel (E)-3-benzylidene-7-methoxychroman-4-one derivatives. Daru (2013) 0.95
Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, C-terminal Src kinase (Csk). J Biol Chem (2006) 0.94
Design and biological evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. Mol Pharm (2013) 0.94
Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs. Eur J Med Chem (2013) 0.94
Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk. Biochemistry (2005) 0.94
Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones. Bioorg Med Chem Lett (2007) 0.93
Selective diphosphorylation, dithiodiphosphorylation, triphosphorylation, and trithiotriphosphorylation of unprotected carbohydrates and nucleosides. Org Lett (2005) 0.93
Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents. Eur J Med Chem (2010) 0.93
Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives. Bioorg Med Chem (2010) 0.93
Effect of Phlomis persica on glucose levels and hepatic enzymatic antioxidants in streptozotocin-induced diabetic rats. Pharmacogn Mag (2010) 0.93
New approach to bone tissue engineering: simultaneous application of hydroxyapatite and bioactive glass coated on a poly(L-lactic acid) scaffold. ACS Appl Mater Interfaces (2011) 0.92
Emtricitabine prodrugs with improved anti-HIV activity and cellular uptake. Mol Pharm (2012) 0.92
Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents. Bioorg Med Chem (2010) 0.92
2,6-hexadecadiynoic acid and 2,6-nonadecadiynoic acid: novel synthesized acetylenic fatty acids as potent antifungal agents. Lipids (2006) 0.92
Effects of low level laser therapy on proliferation and neurotrophic factor gene expression of human schwann cells in vitro. J Photochem Photobiol B (2011) 0.92
Conformational basis for SH2-Tyr(P)527 binding in Src inactivation. J Biol Chem (2006) 0.91
Cyclic peptide-capped gold nanoparticles as drug delivery systems. Mol Pharm (2012) 0.91
Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters. Mol Pharm (2013) 0.91
N-Substituted piperazinyl quinolones as potential cytotoxic agents: structure-activity relationships study. Biomed Pharmacother (2008) 0.91
Solid-phase reagents for selective monophosphorylation of carbohydrates and nucleosides. J Org Chem (2005) 0.91
Synthesis and biological evaluation of fatty acyl ester derivatives of 2',3'-didehydro-2',3'-dideoxythymidine. Bioorg Med Chem Lett (2011) 0.90
Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors. J Med Chem (2010) 0.90
(E)- and (Z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals. Bioorg Med Chem (2004) 0.90
Iran's scientists condemn instances of plagiarism. Nature (2009) 0.90
Application of a solid-phase beta-triphosphitylating reagent in the synthesis of nucleoside beta-triphosphates. J Org Chem (2006) 0.90
Design of conformationally constrained azole antifungals: efficient synthesis and antifungal activity of trans-3-imidazolylflavanones. Chem Biol Drug Des (2009) 0.90
Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1,3,4-thiadiazoles with piperazinyl-linked benzamidine substituents. Eur J Med Chem (2011) 0.89
Quantification of endogenous steroids in human urine by gas chromatography mass spectrometry using a surrogate analyte approach. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.89
Design, synthesis, and calcium channel antagonist activity of new 1,4-dihydropyridines containing 4-(5)-chloro-2-ethyl-5-(4)-imidazolyl substituent. Arch Pharm (Weinheim) (2006) 0.89
A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies. Invest New Drugs (2013) 0.89
Radioprotective effects of citrus extract against gamma-irradiation in mouse bone marrow cells. J Radiat Res (2003) 0.89
Synthesis and antiproliferative activity evaluation of imidazole-based indeno[1,2-b]quinoline-9,11-dione derivatives. Arch Pharm Res (2013) 0.89
Poly (epsilon-caprolactone) nanofibrous ring surrounding a polyvinyl alcohol hydrogel for the development of a biocompatible two-part artificial cornea. Int J Nanomedicine (2011) 0.88
Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine. Mol Pharm (2013) 0.88
Synthesis and cytotoxic evaluation of some new[1,3]dioxolo[4,5-g]chromen-8-one derivatives. Daru (2014) 0.88
Total synthesis and further scrutiny of the in vitro antifungal activity of 6-nonadecynoic acid. Arch Pharm (Weinheim) (2005) 0.88
A new strategy based on pharmacophore-based virtual screening in adenosine deaminase inhibitors detection and in-vitro study. Daru (2012) 0.88
3-substitued indoles: one-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities. Bioorg Med Chem Lett (2011) 0.88
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol (2013) 0.88
Design, Synthesis and Anticonvulsant Activity of 2-(2-Phenoxy) phenyl- 1,3,4-oxadiazole Derivatives. Iran J Pharm Res (2013) 0.88
N,N-Dimethyl-propane-1,2-diaminium bis-(6-carb-oxy-pyridine-2-carboxyl-ate) monohydrate. Acta Crystallogr Sect E Struct Rep Online (2011) 0.88
Development and validation of a rapid HPLC method for simultaneous determination of tramadol, and its two main metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.87
5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety. Daru (2013) 0.87
Synthesis, QSAR and calcium channel antagonist activity of new 1,4-dihydropyridine derivatives containing 1-methyl-4,5-dichloroimidazolyl substituents. Arch Pharm (Weinheim) (2007) 0.87
Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activities. Bioorg Med Chem (2004) 0.87
Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Mol Cancer Ther (2012) 0.87