PubRank

Tim Sparwasser

Author PubWeight™ 149.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 2002 14.57
2 Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 2007 5.52
3 Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006 5.34
4 Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 2011 3.92
5 IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011 3.61
6 T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 2012 2.78
7 An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 2011 2.69
8 Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 2009 2.17
9 Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 2010 2.17
10 CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res 2011 2.03
11 DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 2008 1.99
12 Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 2013 1.89
13 Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 2012 1.88
14 Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. Am J Respir Crit Care Med 2011 1.78
15 Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med 2009 1.78
16 The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood 2009 1.78
17 Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity 2010 1.77
18 Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res 2010 1.71
19 Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 2010 1.66
20 Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 2012 1.64
21 Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 2013 1.61
22 1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression. J Invest Dermatol 2012 1.50
23 Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 2011 1.49
24 CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 2011 1.47
25 In vivo depletion of FoxP3+ Tregs using the DEREG mouse model. Methods Mol Biol 2011 1.43
26 Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med 2012 1.38
27 Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology 2011 1.34
28 Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A 2011 1.26
29 Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathog 2009 1.26
30 Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 2011 1.23
31 CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathog 2010 1.22
32 The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J Exp Med 2006 1.21
33 Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol 2009 1.19
34 The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med 2010 1.18
35 Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS One 2012 1.15
36 FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci U S A 2009 1.15
37 T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med 2010 1.13
38 Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med 2010 1.13
39 Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 2012 1.12
40 Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest 2012 1.09
41 Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation. Mol Immunol 2009 1.09
42 Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J Immunol 2011 1.08
43 Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology 2012 1.08
44 Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 2009 1.07
45 Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice. Hepatology 2012 1.07
46 CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immunol 2011 1.06
47 Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J Immunol 2009 1.06
48 Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation. Blood 2011 1.06
49 Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 2009 1.06
50 Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation. Eur J Immunol 2010 1.04
51 IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog 2013 1.03
52 Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis. J Invest Dermatol 2012 1.03
53 Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. J Immunol 2011 1.02
54 On the role of regulatory T cells during viral-induced inflammatory lesions. J Immunol 2012 1.02
55 Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice. J Clin Invest 2011 1.01
56 Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunol 2008 1.01
57 Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis. Kidney Int 2011 1.01
58 Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A 2011 0.99
59 Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Proc Natl Acad Sci U S A 2011 0.99
60 Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells. Immunobiology 2006 0.99
61 Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells. J Immunol 2011 0.98
62 Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria. J Immunol 2009 0.98
63 Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Eur J Immunol 2014 0.98
64 Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol 2012 0.98
65 Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. Eur J Immunol 2011 0.96
66 Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice. Blood 2012 0.94
67 A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol 2011 0.94
68 Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A 2009 0.93
69 α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation. J Invest Dermatol 2012 0.93
70 Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. J Immunol 2012 0.93
71 Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. J Immunol 2012 0.93
72 Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity. PLoS Pathog 2013 0.92
73 Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol 2009 0.90
74 Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun 2013 0.90
75 The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model. J Invest Dermatol 2012 0.89
76 IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 2012 0.89
77 Tregs in infection and vaccinology: heroes or traitors? Microb Biotechnol 2011 0.89
78 Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 2008 0.89
79 Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest 2015 0.88
80 Foxp3+ regulatory T cells are required for recovery from severe sepsis. PLoS One 2013 0.88
81 Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res 2014 0.87
82 Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation. PLoS One 2012 0.87
83 Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 2011 0.87
84 CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. Eur J Immunol 2014 0.87
85 In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity. J Allergy Clin Immunol 2011 0.86
86 Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. PLoS Pathog 2013 0.85
87 Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells. Blood 2013 0.85
88 Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. Cancer Immunol Immunother 2012 0.84
89 Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity. J Virol 2011 0.84
90 Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice. PLoS One 2012 0.83
91 Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS One 2013 0.82
92 Foxp3(+) regulatory T cells in mouse models of type 1 diabetes. J Diabetes Res 2013 0.82
93 Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology 2013 0.82
94 In vivo targeting of human DC-SIGN drastically enhances CD8⁺ T-cell-mediated protective immunity. Eur J Immunol 2013 0.82
95 Fluorochrome-based definition of naturally occurring Foxp3(+) regulatory T cells of intra- and extrathymic origin. Eur J Immunol 2014 0.81
96 Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells. PLoS Negl Trop Dis 2013 0.81
97 Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS One 2012 0.81
98 Induction of regulatory T cells by a murine β-defensin. J Immunol 2011 0.81
99 MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Eur J Immunol 2014 0.81
100 The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells. Eur J Immunol 2011 0.80
101 Toll-like receptor-2 agonist-allergen coupling efficiently redirects Th2 cell responses and inhibits allergic airway eosinophilia. Am J Respir Cell Mol Biol 2012 0.80
102 Foxp3+ regulatory T cells control persistence of viral CNS infection. PLoS One 2012 0.79
103 Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production. J Biol Chem 2013 0.79
104 Dendritic cell specific targeting of MyD88 signalling pathways in vivo. Eur J Immunol 2014 0.79
105 Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. J Allergy Clin Immunol 2010 0.79
106 Salmonella enterica serovar Typhimurium infection-induced CD11b+ Gr1+ cells ameliorate allergic airway inflammation. Infect Immun 2013 0.78
107 Assessing the suppressive activity of Foxp3⁺ regulatory T cells. Methods Mol Biol 2014 0.78
108 Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells. Virol J 2014 0.77
109 Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model. Immunobiology 2012 0.77
110 HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions. J Immunol 2014 0.75
111 Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2015 0.75