PubRank

Ralf Thoma

Author PubWeight™ 17.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment. Structure 2006 1.60
2 Systematic investigation of halogen bonding in protein-ligand interactions. Angew Chem Int Ed Engl 2011 1.54
3 Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res 2010 1.38
4 Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates. Biochemistry 2002 1.09
5 Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J Mol Biol 2010 0.98
6 Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations. J Mol Biol 2009 0.95
7 Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution. Acta Crystallogr D Biol Crystallogr 2005 0.89
8 Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design. J Mol Biol 2010 0.89
9 The monotopic membrane protein human oxidosqualene cyclase is active as monomer. Biochem Biophys Res Commun 2004 0.87
10 Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog. FEBS Lett 2007 0.87
11 Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones. Acta Crystallogr D Biol Crystallogr 2013 0.84
12 Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin). Acta Crystallogr D Biol Crystallogr 2011 0.84
13 Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments. ChemMedChem 2011 0.82
14 Light it up: highly efficient multigene delivery in mammalian cells. Bioessays 2011 0.82
15 Structural insight into function and regulation of carnitine palmitoyltransferase. Cell Mol Life Sci 2009 0.80
16 Generation of an antibody toolbox to characterize hERG. Biochem Biophys Res Commun 2012 0.80
17 Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds. J Med Chem 2013 0.78
18 Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein. FEBS Open Bio 2013 0.77