Anti-platelet therapy: glycoprotein IIb-IIIa antagonists.

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Published in Br J Clin Pharmacol on October 01, 2011

Authors

David J Schneider1

Author Affiliations

1: Cardiology Unit, Department of Medicine and Cardiovascular Research Unit, University of Vermont, Burlington, VT 05446, USA. david.schneider@uvm.edu

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Exposure of platelet fibrinogen receptors by ADP and epinephrine. J Clin Invest (1979) 4.12

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Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II. Integrilin to Minimise Platelet Aggregation and Coronary Thrombosis-II. Lancet (1997) 2.27

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Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody. Proc Natl Acad Sci U S A (1983) 2.09

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The formation of Ca++-dependent complexes of platelet membrane glycoproteins IIb and IIIa in solution as determined by crossed immunoelectrophoresis. Blood (1981) 1.86

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