| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Benzene disposition in the rat after exposure by inhalation.
|
Toxicol Appl Pharmacol
|
1979
|
1.61
|
|
2
|
Benzene is metabolized and covalently bound in bone marrow in situ.
|
Chem Biol Interact
|
1980
|
1.22
|
|
3
|
Dinitrotoluene: acute toxicity, oncogenicity, genotoxicity, and metabolism.
|
Crit Rev Toxicol
|
1984
|
1.21
|
|
4
|
Metabolism of 2,4-dinitrotoluene by intestinal microorganisms from rat, mouse, and man.
|
Toxicol Appl Pharmacol
|
1982
|
0.99
|
|
5
|
Assessing exposure to dinitrotoluene using a biological monitor.
|
J Occup Med
|
1985
|
0.90
|
|
6
|
Concomitant dietary exposure to polychlorinated biphenyls and polybrominated biphenyls: tissue distribution and arylhydrocarbon hydroxylase activity in lactating rats.
|
Toxicol Appl Pharmacol
|
1979
|
0.90
|
|
7
|
Metabolism and excretion of 2,4-dinitrotoluene in male and female Fischer 344 rats after different doses.
|
Drug Metab Dispos
|
1981
|
0.88
|
|
8
|
Species comparison of acrylonitrile epoxidation by microsomes from mice, rats and humans: relationship to epoxide concentrations in mouse and rat blood.
|
Carcinogenesis
|
1991
|
0.87
|
|
9
|
Dose-dependent uptake, distribution, and elimination of inhaled n-hexane in the Fischer-344 rat.
|
Toxicol Appl Pharmacol
|
1981
|
0.86
|
|
10
|
Metabolism and excretion of 2,4-[14C]Dinitrotoluene in conventional and axenic Fischer-344 rats.
|
Toxicol Appl Pharmacol
|
1981
|
0.86
|
|
11
|
Interactions between depressants (alcohol-type) and stimulants (amphetamine-type).
|
Pharmacol Biochem Behav
|
1978
|
0.85
|
|
12
|
Cyproheptadine and beta cell function in the rat: insulin secretion from pancreas segments in vitro.
|
Proc Soc Exp Biol Med
|
1975
|
0.85
|
|
13
|
Liver and mammary arylhydrocarbon hydroxylase and epoxide hydratase in lactating rats fed polybrominated biphenyls.
|
Life Sci
|
1977
|
0.84
|
|
14
|
Distribution of polybrominated biphenyls after dietary exposure in pregnant and lactating rats and their offspring.
|
Environ Health Perspect
|
1978
|
0.83
|
|
15
|
Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism. Role of flavin-containing monooxygenase.
|
Drug Metab Dispos
|
1985
|
0.81
|
|
16
|
Metabolism of dinitrobenzenes by rat isolated hepatocytes.
|
Drug Metab Dispos
|
1986
|
0.80
|
|
17
|
18O studies of the peroxidase-catalyzed oxidation of N-methylcarbazole. Mechanisms of carbinolamine and carboxaldehyde formation.
|
J Biol Chem
|
1986
|
0.80
|
|
18
|
A novel method for the separation and quantitation of benzene metabolites using high-pressure liquid chromatography.
|
Anal Biochem
|
1981
|
0.80
|
|
19
|
Stimulation of hepatic and renal mixed-function oxidase in developing rats by polybrominated biphenyls.
|
Drug Metab Dispos
|
1980
|
0.80
|
|
20
|
Studies on the biological disposition of diethylstilbestrol in rats and humans.
|
J Toxicol Environ Health
|
1976
|
0.80
|
|
21
|
Metabolism and excretion of 2,6-dinitro [14C]toluene in vivo and in isolated perfused rat livers.
|
Drug Metab Dispos
|
1983
|
0.80
|
|
22
|
Hepatic macromolecular covalent binding of the hepatocarcinogen 2,6-dinitrotoluene and its 2,4-isomer in vivo: modulation by the sulfotransferase inhibitors pentachlorophenol and 2,6-dichloro-4-nitrophenol.
|
Carcinogenesis
|
1984
|
0.79
|
|
23
|
Cell specificity in DNA binding and repair of chemical carcinogens.
|
Environ Health Perspect
|
1983
|
0.79
|
|
24
|
Benzpyrene pretreatment changes the kinetics and pH optimum for aniline hydroxylation in vitro, but not those for benzphetamine demethylation in vitro by rat liver microsomes.
|
Biochem Pharmacol
|
1970
|
0.79
|
|
25
|
Activation of hydrocortisone-induced tryptophan pyrrolase of rat liver by SKF 525-A. The possible involvement of antidiuretic hormone.
|
Biochem Pharmacol
|
1968
|
0.79
|
|
26
|
Metabolism and excretion of dinitrobenzenes by male Fischer-344 rats.
|
Drug Metab Dispos
|
1988
|
0.79
|
|
27
|
Identification and quantification of urinary metabolites of dinitrotoluenes in occupationally exposed humans.
|
Toxicol Appl Pharmacol
|
1985
|
0.78
|
|
28
|
Inhibition of the microsomal N-hydroxylation of 2-amino-6-nitrotoluene by a metabolite of methimazole.
|
Biochem Biophys Res Commun
|
1983
|
0.78
|
|
29
|
Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans.
|
Toxicol Appl Pharmacol
|
1992
|
0.78
|
|
30
|
Elimination and metabolism of permethrin isomers in rainbow trout.
|
Toxicol Appl Pharmacol
|
1981
|
0.78
|
|
31
|
A critical review of the literature on nitrobenzene toxicity.
|
Crit Rev Toxicol
|
1982
|
0.78
|
|
32
|
Mixed function oxidase activities in lactating rats and their offspring following dietary exposure to polybrominated biphenyls.
|
Toxicol Appl Pharmacol
|
1978
|
0.77
|
|
33
|
Metabolism of acrylonitrile to 2-cyanoethylene oxide in F-344 rat liver microsomes, lung microsomes, and lung cells.
|
Drug Metab Dispos
|
1989
|
0.77
|
|
34
|
Analytical approaches to the study of the disposition of myelotoxic agents.
|
Environ Health Perspect
|
1981
|
0.77
|
|
35
|
Pancreatic islet-cell toxicity.
|
CRC Crit Rev Toxicol
|
1975
|
0.77
|
|
36
|
Sex-dependent metabolism and biliary excretion of [2,4-14C] dinitrotoluene in isolated perfused rat livers.
|
J Pharmacol Exp Ther
|
1981
|
0.77
|
|
37
|
Cyproheptadine-induced depletion of insulin in the rat.
|
J Pharmacol Exp Ther
|
1975
|
0.77
|
|
38
|
Renal and hepatic microsomal enzyme stimulation and renal function following three months of dietary exposure to polybrominated biphenyls.
|
Toxicol Appl Pharmacol
|
1978
|
0.76
|
|
39
|
Effect of glutathione depletion on the irreversible association of acrylonitrile with tissue macromolecules after oral administration to rats.
|
Toxicol Appl Pharmacol
|
1988
|
0.76
|
|
40
|
Source of the oxygen atom in the product of cytochrome P-450-catalyzed N-demethylation reactions.
|
Mol Pharmacol
|
1983
|
0.76
|
|
41
|
Induction of hepatic and testicular lesions in Fischer-344 rats by single oral doses of nitrobenzene.
|
Fundam Appl Toxicol
|
1983
|
0.76
|
|
42
|
Metabolism of 2-methylnaphthalene in the rat in vivo. I. Identification of 2-naphthoylglycine.
|
Drug Metab Dispos
|
1982
|
0.76
|
|
43
|
The pharmacokinetics and extra-hepatic clearance of remifentanil, a short acting opioid agonist, in male beagle dogs during constant rate infusions.
|
Drug Metab Dispos
|
1996
|
0.76
|
|
44
|
Effects of pectin-containing diets on the hepatic macromolecular covalent binding of 2,6-dinitro-[3H]toluene in Fischer-344 rats.
|
Toxicol Appl Pharmacol
|
1983
|
0.75
|
|
45
|
Hepatic macromolecular covalent binding of mononitrotoluenes in Fischer-344 rats.
|
Chem Biol Interact
|
1984
|
0.75
|
|
46
|
The effects of diet on the toxicity of nitroaromatic chemicals in rodents.
|
Dev Toxicol Environ Sci
|
1986
|
0.75
|
|
47
|
In vitro activation of 2-aminobenzyl alcohol and 2-amino-6-nitrobenzyl alcohol, metabolites of 2-nitrotoluene and 2,6-dinitrotoluene.
|
Chem Res Toxicol
|
1992
|
0.75
|
|
48
|
Effect of polybrominated biphenyls on the development of hepatic excretory function.
|
J Pharmacol Exp Ther
|
1979
|
0.75
|
|
49
|
The absorption and first-pass metabolism of [14C]-1,3-dinitrobenzene in the isolated vascularly perfused rat small intestine.
|
Biopharm Drug Dispos
|
1996
|
0.75
|
|
50
|
Tissue distribution of 2,4-dinitrotoluene and its metabolites in male and female Fischer-344 rats.
|
Toxicol Appl Pharmacol
|
1980
|
0.75
|
|
51
|
Metabolism and toxicity of dinitrobenzene isomers in erythrocytes from Fischer-344 rats, rhesus monkeys and humans.
|
Toxicol Lett
|
1987
|
0.75
|
|
52
|
Studies on the disposition and metabolism of pentachloroanisole in female mice.
|
Toxicol Appl Pharmacol
|
1980
|
0.75
|
|
53
|
Metabolism of nitrotoluenes by freshly isolated Fischer 344 rat hepatocytes.
|
Drug Metab Dispos
|
1984
|
0.75
|
|
54
|
Metabolism and excretion of nitrobenzene by rats and mice.
|
Toxicol Appl Pharmacol
|
1983
|
0.75
|
|
55
|
Absorption and glucuronylation of diethylstilbestrol by the rat small intestine.
|
Xenobiotica
|
1978
|
0.75
|
|
56
|
Increased blood pressure in the SHR is not related to a deficit in renomedullary PGE2.
|
Experientia
|
1978
|
0.75
|
|
57
|
Sequential enzyme-catalyzed metabolism of 4-nitrotoluene to S-(4-nitrobenzyl)glutathione.
|
Biochem Biophys Res Commun
|
1983
|
0.75
|
|
58
|
Effect of glutathione depletion on the uptake of acrylonitrile vapors and on its irreversible association with tissue macromolecules.
|
Toxicol Appl Pharmacol
|
1988
|
0.75
|
|
59
|
Functional and biochemical disposition of 7,12-dimethylbenz[a]anthracene in murine lymphoid cells.
|
Chem Biol Interact
|
1989
|
0.75
|
|
60
|
Hepatic macromolecular covalent binding and intestinal disposition of [14C]dinitrotoluenes.
|
J Toxicol Environ Health
|
1983
|
0.75
|
|
61
|
Effect of growth state, tumor promoters, and transformation upon intercellular communication between C3H/10T1/2 murine fibroblasts.
|
Carcinogenesis
|
1989
|
0.75
|
|
62
|
Mechanisms of N-demethylation reactions catalyzed by cytochrome P-450 and peroxidases.
|
Drug Metab Dispos
|
1985
|
0.75
|
|
63
|
Kinetics of conjugation and oxidation of nitrobenzyl alcohols by rat hepatic enzymes.
|
Biochem Pharmacol
|
1985
|
0.75
|
|
64
|
Cyproheptadine-induced insulin depletion in rat pancreatic beta cells: demonstration by light and electron microscopic immunocytochemistry.
|
Horm Metab Res
|
1976
|
0.75
|
|
65
|
Metabolism and carcinogenicity of nitrotoluenes.
|
Adv Exp Med Biol
|
1986
|
0.75
|
|
66
|
The metabolism and excretion of mononitrotoluenes by Fischer 344 rats.
|
Drug Metab Dispos
|
1985
|
0.75
|
|
67
|
Relationship between red blood cell uptake and methemoglobin production by nitrobenzene and dinitrobenzene in vitro.
|
Life Sci
|
1985
|
0.75
|
|
68
|
Diminished drug metabolism due to hormonal effects of cobalt mesoporphyrin on flavoproteins.
|
Chem Biol Interact
|
1993
|
0.75
|
|
69
|
Mass fragmentographic determination of 3, 4 dihydroxyphenylethylamine and 4-hydrox-3-methoxyphenylethylamine in the caudate nucleus.
|
J Neurochem
|
1977
|
0.75
|
|
70
|
The effect of diet on 2,6-dinitrotoluene hepatocarcinogenesis.
|
Carcinogenesis
|
1986
|
0.75
|
|
71
|
Macromolecular covalent binding of [14C]nitrobenzene in the erythrocyte and spleen of rats and mice.
|
Chem Biol Interact
|
1984
|
0.75
|
|
72
|
Isomer- and sex-specific bioactivation of mononitrotoluenes. Role of enterohepatic circulation.
|
Drug Metab Dispos
|
1986
|
0.75
|
|
73
|
Characterization of the oxidation of amine metabolites of nitrotoluenes by rat hepatic microsomes. N- and C-hydroxylation.
|
Mol Pharmacol
|
1985
|
0.75
|
|
74
|
Structure-activity relationships in drug-induced pancreatic islet cell toxicity.
|
Toxicol Appl Pharmacol
|
1973
|
0.75
|
|
75
|
Metabolism of [14C]1,3-dinitrobenzene by rat small intestinal mucosa in vitro.
|
Drug Metab Dispos
|
1995
|
0.75
|
|
76
|
Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.
|
J Pharmacol Exp Ther
|
1988
|
0.75
|
|
77
|
Metabolism of 2,4-dinitro[14C]toluene by freshly isolated Fischer-344 rat primary hepatocytes.
|
Drug Metab Dispos
|
1981
|
0.75
|