Published in PLoS One on September 21, 2011
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev (2013) 2.01
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev (2015) 1.81
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev (2012) 1.74
A bilayer-couple model of bacterial outer membrane vesicle biogenesis. MBio (2012) 1.05
Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate. PLoS One (2012) 1.00
The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice. Antimicrob Agents Chemother (2015) 0.93
Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2014) 0.92
Emergence and spread of antibiotic resistance: setting a parameter space. Ups J Med Sci (2014) 0.90
Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. PLoS One (2012) 0.89
The stringent response modulates 4-hydroxy-2-alkylquinoline biosynthesis and quorum-sensing hierarchy in Pseudomonas aeruginosa. J Bacteriol (2014) 0.87
Gene PA2449 is essential for glycine metabolism and pyocyanin biosynthesis in Pseudomonas aeruginosa PAO1. J Bacteriol (2013) 0.86
MexT functions as a redox-responsive regulator modulating disulfide stress resistance in Pseudomonas aeruginosa. J Bacteriol (2012) 0.86
Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa. Chembiochem (2014) 0.86
A fluorescent microplate assay quantifies bacterial efflux and demonstrates two distinct compound binding sites in AcrB. Antimicrob Agents Chemother (2015) 0.83
Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa. BMC Genomics (2013) 0.83
Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations. Curr Top Microbiol Immunol (2013) 0.83
Efflux-mediated fluoroquinolone resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7: identification of a novel MexS variant involved in upregulation of the mexEF-oprN multidrug efflux operon. Front Microbiol (2015) 0.82
Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF. J Bacteriol (2013) 0.80
Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence. Front Microbiol (2016) 0.78
Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2016) 0.78
The role of 2,4-dihydroxyquinoline (DHQ) in Pseudomonas aeruginosa pathogenicity. PeerJ (2016) 0.77
The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development. Proc Natl Acad Sci U S A (2016) 0.77
GcsR, a TyrR-Like Enhancer-Binding Protein, Regulates Expression of the Glycine Cleavage System in Pseudomonas aeruginosa PAO1. mSphere (2016) 0.77
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence. Front Cell Infect Microbiol (2017) 0.76
Contribution of the A. baumannii A1S_0114 Gene to the Interaction with Eukaryotic Cells and Virulence. Front Cell Infect Microbiol (2017) 0.75
Pseudomonas aeruginosa DesB Promotes Staphylococcus aureus Growth Inhibition in Coculture by Controlling the Synthesis of HAQs. PLoS One (2015) 0.75
Toxic Electrophiles Induce Expression of the Multidrug Efflux Pump MexEF-OprN in Pseudomonas aeruginosa through a Novel Transcriptional Regulator, CmrA. Antimicrob Agents Chemother (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol (1988) 31.85
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol (1994) 17.55
Quorum sensing in bacteria. Annu Rev Microbiol (2001) 14.41
Common virulence factors for bacterial pathogenicity in plants and animals. Science (1995) 11.22
Comprehensive transposon mutant library of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2003) 10.63
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A (2006) 8.85
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants. Proc Natl Acad Sci U S A (2006) 7.62
A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol Microbiol (1996) 6.07
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol Microbiol (1997) 5.91
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (1999) 5.58
Cystic fibrosis. Lancet (2009) 5.40
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother (2001) 5.23
Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol (2006) 5.18
Cystic fibrosis. Lancet (2003) 5.00
Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains. Plasmid (2000) 4.67
Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J Bacteriol (1999) 4.42
Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa. J Bacteriol (2002) 3.91
Efflux-mediated antimicrobial resistance. J Antimicrob Chemother (2005) 3.69
Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins. Microbiology (2008) 3.68
Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci U S A (2004) 3.30
Initiation of biofilm formation by Pseudomonas aeruginosa 57RP correlates with emergence of hyperpiliated and highly adherent phenotypic variants deficient in swimming, swarming, and twitching motilities. J Bacteriol (2001) 3.01
Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol (2001) 2.97
Pseudomonas aeruginosa - a phenomenon of bacterial resistance. J Med Microbiol (2009) 2.78
The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa. J Bacteriol (2001) 2.76
Integration-proficient Pseudomonas aeruginosa vectors for isolation of single-copy chromosomal lacZ and lux gene fusions. Biotechniques (2000) 2.73
Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules. Curr Opin Microbiol (2009) 2.64
Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa. J Bacteriol (1998) 2.61
Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa. J Bacteriol (2001) 2.28
MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Mol Microbiol (2006) 2.12
Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. J Bacteriol (2005) 2.07
Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother (2000) 2.07
Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. Curr Top Med Chem (2001) 2.04
Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system. J Bacteriol (2002) 1.99
Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. J Bacteriol (1999) 1.96
Genome-wide internal tagging of bacterial exported proteins. Nat Biotechnol (2002) 1.92
Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa. J Am Soc Mass Spectrom (2004) 1.85
nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1995) 1.73
Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa. FEMS Microbiol Lett (2000) 1.60
Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation. Mol Microbiol (2008) 1.56
Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry. Microbiology (2006) 1.50
A stable isotope dilution assay for the quantification of the Pseudomonas quinolone signal in Pseudomonas aeruginosa cultures. Biochim Biophys Acta (2003) 1.43
The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology (2005) 1.43
Enhancement of the mexAB-oprM efflux pump expression by a quorum-sensing autoinducer and its cancellation by a regulator, MexT, of the mexEF-oprN efflux pump operon in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2004) 1.40
Pseudomonas aeruginosa attachment and biofilm development in dynamic environments. Mol Microbiol (2004) 1.35
Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin. J Antimicrob Chemother (2003) 1.34
Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother (2010) 1.33
Improving the reproducibility of Pseudomonas aeruginosa swarming motility assays. J Basic Microbiol (2008) 1.30
CFTR mutations and host susceptibility to Pseudomonas aeruginosa lung infection. Curr Opin Microbiol (2002) 1.29
Mutations in PA2491 (mexS) promote MexT-dependent mexEF-oprN expression and multidrug resistance in a clinical strain of Pseudomonas aeruginosa. J Bacteriol (2005) 1.29
Transcriptome analysis of Pseudomonas aeruginosa after interaction with human airway epithelial cells. Infect Immun (2004) 1.29
Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH. Mol Microbiol (2010) 1.23
mexEF-oprN multidrug efflux operon of Pseudomonas aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol. Antimicrob Agents Chemother (2010) 1.12
Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats. Antimicrob Agents Chemother (2001) 1.05
MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump. Microb Pathog (2009) 1.00
A quorum-sensing autoinducer enhances the mexAB-oprM efflux-pump expression without the MexR-mediated regulation in Pseudomonas aeruginosa. Microbiol Immunol (2004) 1.00
Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa. Nucleic Acids Res (2009) 0.99
Analysis of LuxR regulon gene expression during quorum sensing in Vibrio fischeri. J Bacteriol (2007) 0.93
Production of Pseudomonas aeruginosa Intercellular Small Signaling Molecules in Human Burn Wounds. J Pathog (2011) 0.86
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol (2006) 3.75
The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc Natl Acad Sci U S A (2004) 3.01
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol (2007) 2.87
MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Mol Microbiol (2006) 2.12
Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2006) 1.95
Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa. J Am Soc Mass Spectrom (2004) 1.85
Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors. Microbiology (2009) 1.74
Production of rhamnolipids by Pseudomonas aeruginosa. Appl Microbiol Biotechnol (2005) 1.70
Rhamnolipids: diversity of structures, microbial origins and roles. Appl Microbiol Biotechnol (2010) 1.62
Self-produced extracellular stimuli modulate the Pseudomonas aeruginosa swarming motility behaviour. Environ Microbiol (2007) 1.59
Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation. Plant Physiol (2003) 1.50
Swarming motility: a multicellular behaviour conferring antimicrobial resistance. Environ Microbiol (2008) 1.46
Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS Pathog (2007) 1.38
Staphylococcus aureus small-colony variants are independently associated with worse lung disease in children with cystic fibrosis. Clin Infect Dis (2013) 1.34
The various lifestyles of the Burkholderia cepacia complex species: a tribute to adaptation. Environ Microbiol (2010) 1.33
Improving the reproducibility of Pseudomonas aeruginosa swarming motility assays. J Basic Microbiol (2008) 1.30
Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation. J Bacteriol (2008) 1.27
Homeostatic interplay between bacterial cell-cell signaling and iron in virulence. PLoS Pathog (2010) 1.22
Burkholderia diversity and versatility: an inventory of the extracellular products. J Microbiol Biotechnol (2007) 1.17
Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide. BMC Microbiol (2010) 1.16
Gene expression in Pseudomonas aeruginosa swarming motility. BMC Genomics (2010) 1.15
Full virulence of Pseudomonas aeruginosa requires OprF. Infect Immun (2010) 1.12
Increase in rhamnolipid synthesis under iron-limiting conditions influences surface motility and biofilm formation in Pseudomonas aeruginosa. J Bacteriol (2010) 1.10
Burkholderia thailandensis harbors two identical rhl gene clusters responsible for the biosynthesis of rhamnolipids. BMC Microbiol (2009) 1.08
PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis. Biol Chem (2007) 0.98
Vfm a new quorum sensing system controls the virulence of Dickeya dadantii. Environ Microbiol (2012) 0.92
Conserved virulence factors of Pseudomonas aeruginosa are required for killing Bacillus subtilis. J Microbiol (2005) 0.92
Phase variation has a role in Burkholderia ambifaria niche adaptation. ISME J (2009) 0.90
Identification and characterization of a novel CprA reductive dehalogenase specific to highly chlorinated phenols from Desulfitobacterium hafniense strain PCP-1. Appl Environ Microbiol (2010) 0.89
Drosophila melanogaster as a model host for the Burkholderia cepacia complex. PLoS One (2010) 0.88
Liquid chromatographic/mass spectrometric detection of the 3-(3-hydroxyalkanoyloxy) alkanoic acid precursors of rhamnolipids in Pseudomonas aeruginosa cultures. J Mass Spectrom (2002) 0.87
Liquid chromatography/mass spectrometry for the detection and quantification of N-acyl-L-homoserine lactones and 4-hydroxy-2-alkylquinolines. Methods Mol Biol (2011) 0.85
Monorhamnolipids and 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs) production using Escherichia coli as a heterologous host. Appl Microbiol Biotechnol (2006) 0.84
Bacterial diversity of a consortium degrading high-molecular-weight polycyclic aromatic hydrocarbons in a two-liquid phase biosystem. Microb Ecol (2008) 0.84
The complex symbiotic relationships of bark beetles with microorganisms: a potential practical approach for biological control in forestry. Pest Manag Sci (2012) 0.83
Identification of quorum sensing-controlled genes in Burkholderia ambifaria. Microbiologyopen (2013) 0.82
Liquid chromatography/mass spectrometry for the identification and quantification of rhamnolipids. Methods Mol Biol (2014) 0.81
The fruit fly as a meeting place for microbes. Cell Host Microbe (2008) 0.80
The extra-cytoplasmic function sigma factor sigX modulates biofilm and virulence-related properties in Pseudomonas aeruginosa. PLoS One (2013) 0.80
Cassava wastewater as a substrate for the simultaneous production of rhamnolipids and polyhydroxyalkanoates by Pseudomonas aeruginosa. J Ind Microbiol Biotechnol (2009) 0.78
Recovery of Pseudomonas aeruginosa culturability following copper- and chlorine-induced stress. FEMS Microbiol Lett (2014) 0.78
A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific analysis of enoyl-coenzyme A hydratases/isomerases. J Chromatogr A (2013) 0.77
Cyclic-di-GMP levels affect Pseudomonas aeruginosa fitness in the presence of imipenem. Environ Microbiol (2014) 0.77
Biodegradation of endocrine disruptors in solid-liquid two-phase partitioning systems by enrichment cultures. Appl Environ Microbiol (2013) 0.76
Systematic mutational analysis of the putative hydrolase PqsE: toward a deeper molecular understanding of virulence acquisition in Pseudomonas aeruginosa. PLoS One (2013) 0.76
Cyclic-di-GMP levels affect Pseudomonas aeruginosa fitness in the presence of imipenem. Environ Microbiol (2014) 0.75