PubRank

Giancarlo A Biagini

Author PubWeight™ 33.64‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol 2007 2.54
2 Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother 2010 1.42
3 PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Mol Microbiol 2006 1.33
4 Inhibiting Plasmodium cytochrome bc1: a complex issue. Curr Opin Chem Biol 2010 1.19
5 Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria. PLoS One 2008 1.18
6 Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angew Chem Int Ed Engl 2007 1.17
7 Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. J Biol Chem 2012 1.10
8 Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. J Antimicrob Chemother 2013 1.07
9 Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment. Mol Biochem Parasitol 2009 1.05
10 A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. Curr Top Med Chem 2006 1.01
11 Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays. Methods Enzymol 2009 1.01
12 Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. J Med Chem 2009 1.01
13 Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem 2010 0.98
14 Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. Antimicrob Agents Chemother 2006 0.96
15 A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites. Biochem J 2008 0.96
16 Resisting resistance: dealing with the irrepressible problem of malaria. Br J Clin Pharmacol 2006 0.91
17 Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary. Trends Parasitol 2007 0.91
18 Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite. Malar J 2009 0.90
19 Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). J Med Chem 2012 0.90
20 HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex. Antimicrob Agents Chemother 2012 0.88
21 Antimalarial pharmacology and therapeutics of atovaquone. J Antimicrob Chemother 2013 0.84
22 Antitubercular pharmacodynamics of phenothiazines. J Antimicrob Chemother 2012 0.83
23 Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era. Future Med Chem 2013 0.82
24 Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+. Antimicrob Agents Chemother 2005 0.82
25 The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. J Biol Chem 2011 0.81
26 Trichomonas vaginalis and Giardia intestinalis produce nitric oxide and display NO-synthase activity. J Eukaryot Microbiol 2006 0.81
27 Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents. J Med Chem 2010 0.80
28 Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues. ChemMedChem 2011 0.80
29 Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). J Med Chem 2012 0.79
30 Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress. PLoS One 2013 0.79
31 An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum. J Biol Chem 2010 0.76
32 A yeast expression system for functional and pharmacological studies of the malaria parasite Ca²⁺/H⁺ antiporter. Malar J 2012 0.76
33 Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. Angew Chem Int Ed Engl 2016 0.76
34 Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods. J Med Chem 2012 0.75
35 Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. J Med Chem 2013 0.75
36 Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁. Bioorg Med Chem 2011 0.75