PubRank

T K Sawyer

Author PubWeight™ 77.77‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Naegleria and Acanthamoeba infections: review. Rev Infect Dis 1990 2.92
2 A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science 1990 2.80
3 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A 1980 2.80
4 Leptomyxid ameba, a new agent of amebic meningoencephalitis in humans and animals. J Clin Microbiol 1990 1.88
5 Substrate specificity of the protein tyrosine phosphatases. Proc Natl Acad Sci U S A 1993 1.84
6 alpha-Melanotropin: the minimal active sequence in the frog skin bioassay. J Med Chem 1987 1.75
7 Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene 2006 1.73
8 Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. Br J Cancer 2006 1.67
9 Characterization of an axenic strain of Hartmannella vermiformis obtained from an investigation of nosocomial legionellosis. J Protozool 1991 1.56
10 Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. Biochemistry 1991 1.48
11 Alpha-melanotropin: the minimal active sequence in the lizard skin bioassay. Gen Comp Endocrinol 1989 1.34
12 Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates. J Virol 1990 1.33
13 Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates. Biochemistry 1994 1.32
14 Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2. J Biol Chem 1990 1.29
15 Pathogenic amoebas from brackish and ocean sediments, with a description of Acanthamoeba hatchetti, n. sp. Science 1977 1.28
16 Substrate analogue inhibition and active site titration of purified recombinant HIV-1 protease. Biochemistry 1990 1.26
17 Isolation of amoebae and Pseudomonas and Legionella spp. from eyewash stations. Appl Environ Microbiol 1991 1.16
18 Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. J Med Chem 1997 1.14
19 [half-Cys4,half-Cys10]-alpha-Melanocyte-stimulating hormone: a cyclic alpha-melanotropin exhibiting superagonist biological activity. Proc Natl Acad Sci U S A 1982 1.14
20 Calcium-dependent prolonged effects on melanophores of [4-norleucine, 7-D-phenylalanine]-alpha-melanotropin. Science 1981 1.10
21 Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease. J Biol Chem 1990 1.03
22 The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors. J Biol Chem 1993 1.01
23 Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity. Peptides 1996 1.00
24 Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists. Drug Des Discov 1996 0.95
25 Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption. Bone 2001 0.93
26 Adenosine and divalent cation effects on S-91 melanoma adenylate cyclase. Arch Biochem Biophys 1980 0.93
27 Iothalamate sodium I 125 vs cyanocobalamin Co 57 as a measure of glomerular filtration rate in man. JAMA 1968 0.92
28 Iodination associated inactivation of beta-melanocyte stimulating hormone. Biochem Biophys Res Commun 1979 0.89
29 Dialysis for endstage diabetic nephropathy. Proc Clin Dial Transplant Forum 1971 0.89
30 Design, synthesis, and conformation of superpotent and prolonged acting melanotropins. Ann N Y Acad Sci 1993 0.88
31 Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Res 1996 0.86
32 Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2. Proteins 1991 0.86
33 Survey of fresh vegetables for nematodes, amoebae, and Salmonella. J Assoc Off Anal Chem 1984 0.86
34 A Src SH2 selective binding compound inhibits osteoclast-mediated resorption. Chem Biol 2000 0.86
35 Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70. J Med Chem 1999 0.86
36 Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70. Bioorg Med Chem Lett 1999 0.85
37 Design, synthesis, and biological activities of a potent and selective alpha-melanotropin antagonist. Int J Pept Protein Res 1990 0.85
38 Targeting signal transduction in the discovery of antiproliferative drugs. Chem Biol 1996 0.85
39 Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J Med Chem 1997 0.84
40 Enzymological studies of melanotropins. Comp Biochem Physiol B 1984 0.83
41 Discovery and development of novel melanogenic drugs. Melanotan-I and -II. Pharm Biotechnol 1998 0.83
42 Systemic cardiovascular and renal hemodynamic alterations during peridural anesthesia in normal man. Anesthesiology 1969 0.83
43 Serum albumin concentration-related Health Care Financing Administration quality assurance criterion is method-dependent: revision is necessary. Am J Kidney Dis 1993 0.82
44 Synthesis and structure-function studies of melanocyte stimulating hormone analogues modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclase. J Med Chem 1980 0.82
45 A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg Med Chem Lett 2001 0.82
46 X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor. J Med Chem 2001 0.82
47 Distribution and possible interrelationships of pathogenic and nonpathogenicAcanthamoeba from aquatic environments. Microb Ecol 1982 0.81
48 Design and structure-activity relationships of C-terminal cyclic neurotensin fragment analogues. J Med Chem 1995 0.81
49 Peptide and peptidomimetic libraries. Molecular diversity and drug design. Mol Biotechnol 1998 0.81
50 Potent and sustained satiety actions of a cholecystokinin octapeptide analogue. Am J Clin Nutr 1992 0.81
51 Nematospiroides dubius: development and passage in the germfree mouse, and a comparative study of the free-living stages in germfree feces and conventional cultures. Trans Am Microsc Soc 1969 0.80
52 Acanthamoeba pearcei n. sp. (Protozoa: Amoebida) from sewage contaminated sediments. J Eukaryot Microbiol 1996 0.79
53 Conformational and dynamic considerations in the design of peptide hormone analogs. Biopolymers 1983 0.79
54 Structure-activity and conformational studies of a series of modified C-terminal hexapeptide neurotensin analogues. Int J Pept Protein Res 1994 0.78
55 Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin. J Med Chem 1990 0.78
56 Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells. Gen Comp Endocrinol 1997 0.78
57 Comparative biological activities of highly potent active-site analogues of alpha-melanotropin. J Med Chem 1982 0.78
58 An experimental method for the determination of enzyme-competitive inhibitor dissociation constants from displacement curves: application to human renin using fluorescence energy transfer to a synthetic dansylated inhibitor peptide. Anal Biochem 1989 0.78
59 Behavioral effects of [4-norleucine, 7-D-phenylalanine]-alpha-melanocyte-stimulating hormone. Peptides 1984 0.77
60 Renal hemodynamic effects of general anesthesia in outpatients. Anesth Analg 1973 0.77
61 An Isonema-like flagellate (Protozoa: Mastigophora) infection in larval geoduck clams, Panope abrupta. J Invertebr Pathol 1987 0.77
62 Simultaneous systemic cardiovascular and renal hemodynamic measurements during high spinal anaesthesia in normal man. Acta Anaesthesiol Scand Suppl 1969 0.77
63 Substrate specificity and inhibitor structure-activity relationships of recombinant human renin: implications in the in vivo evaluation of renin inhibitors. Biotechnol Appl Biochem 1990 0.77
64 Association of prokaryotes with symptomatic appearance of withering syndrome in black abalone Haliotis cracherodii. J Invertebr Pathol 1995 0.77
65 A molecular approach to the phylogeny of Acanthamoeba. Biosystems 1985 0.77
66 Structure-activity studies of highly potent cyclic [Cys4,Cys10]Melanotropin analogues. J Med Chem 1983 0.77
67 Korotnevella hemistylolepis n. sp. and Korotnevella monacantholepis n. sp. (Paramoebidae), two new scale-covered mesohaline amoebae. J Eukaryot Microbiol 2002 0.77
68 Contamination of tissue sections of the American oyster by cysts of Acanthamoeba sp. J Invertebr Pathol 1971 0.76
69 Sequence specificity in the recognition of the epidermal growth factor receptor by the abl Src homology 2 domain. Oncogene 1994 0.76
70 Biological actions of melanocyte-stimulating hormone. Ciba Found Symp 1981 0.76
71 Design of peptidomimetic ligands for the pp60src SH2 domain. Bioorg Med Chem 1997 0.76
72 Structural and conformational modifications of alpha-MSH/ACTH4-10 provide melanotropin analogues with highly potent behavioral activities. Peptides 1985 0.76
73 Melanotropin structure-activity studies on melanocytes of the teleost fish, Synbranchus marmoratus. Gen Comp Endocrinol 1989 0.76
74 Marine amoebae from surface waters of chincoteague bay, Virginia: one new genus and eleven new species within the families Thecamoebidae and Hyalodiscidae. Trans Am Microsc Soc 1975 0.76
75 The actions of melanin-concentrating hormone (MCH) on passive avoidance in rats: a preliminary study. Peptides 1994 0.75
76 Quantitative determination of amino acid racemization in heat--alkali-treated melanotropins: implications for peptide hormone structure--function studies. Anal Biochem 1981 0.75
77 The effects of structure-conformation modifications of melanotropin analogs on learning and memory: D-amino acid substituted linear and cyclic analogs. Peptides 1989 0.75
78 Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain. J Med Chem 2000 0.75
79 Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S. Protein Sci 1995 0.75
80 Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site. J Med Chem 1988 0.75
81 Hydrophobic D-amino acids in the design of peptide ligands for the pp60src SH2 domain. Drug Des Discov 1996 0.75
82 Signal transduction drug discovery: targets, mechanisms and structure-based design. Curr Opin Drug Discov Devel 2000 0.75
83 Clydonella N. G. (Amoebida: Thecamoebidae), proposed to provide an appropriate generic home for Schaeffer's marine species of Rugipes, C. vivax (Schaeffer, 1926) n. comb. Trans Am Microsc Soc 1975 0.75
84 Synthesis of aminobenzoic Acid-based nonpeptide templates : applications in peptidomimetic drug discovery. Methods Mol Med 1999 0.75
85 Functional activity of new C-terminal cyclic-neurotensin fragment analogs. Neuropeptides 1996 0.75
86 Synthesis of a new hydroxyethylene dipeptide isostere Phe psi [CH2CH (OH)]Phe as HIV-1 protease inhibitor. Zhongguo Yao Li Xue Bao 1994 0.75
87 The evaluation of non-viral substrates of the HIV protease as leads in the design of inhibitors for AIDS therapy. Adv Exp Med Biol 1991 0.75
88 Structure-based design and solid-phase parallel synthesis of phosphorylated nonpeptides to explore hydrophobic binding at the Src SH2 domain. J Comb Chem 2000 0.75
89 Henneguya sp. (Cnidospora:Myxosporida) parasitic in the heart of the bluefish, Pomatomus saltatrix. J Parasitol 1977 0.75
90 Comparative biological activities of potent active-site analogues of alpha-melanotropin. Effect of tyrosine substitution at position-4. Int J Pept Protein Res 1984 0.75
91 Molting and exsheathment in vitro of third-stage Dirofilaria immitis. J Parasitol 1965 0.75
92 Stereoselective synthesis of Xaa psi[CH2CH(OH)]Yaa dipeptidomimetics and their inclusion in HIV-1 protease inhibitors. Int J Pept Protein Res 1995 0.75
93 Discovery of an alpha-melanotropin antagonist effective in vivo. Peptides 1994 0.75
94 Multiple and combinatorial peptide synthesis. Chemical development and biological applications. Methods Mol Biol 1994 0.75
95 Home dialysis for kidney failure. N Engl J Med 1973 0.75
96 Structure-conformation relationships of synthetic peptide inhibitors of human renin studied by resonance energy transfer and molecular modeling. Int J Pept Protein Res 1988 0.75
97 [Cardiovascular and renal hemodynamics during high spinal and peridural anaesthesia]. Anaesthesist 1972 0.75
98 Racemization effects on melanocyte-stimulating hormones and related peptides. J Endocrinol 1981 0.75
99 Differentiation of the structural features of melanotropins important for biological potency and prolonged activity in vitro. Int J Pept Protein Res 1983 0.75
100 Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. J Med Chem 1997 0.75
101 Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide. Bioorg Med Chem Lett 2001 0.75
102 Spectroscopic analysis of [Trp3]-beta-casomorphin analogs. Comparative structure conformation-activity studies. Int J Pept Protein Res 1991 0.75
103 Thecamoeba hoffmani sp. n. (Amoebida: Thecamoebidae) from gills of fingerling salmonid fish. J Parasitol 1974 0.75
104 Home hemodialysis training in 3 weeks. Trans Am Soc Artif Intern Organs 1972 0.75
105 Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors. J Med Chem 1995 0.75
106 alpha-MSH analogues and adrenal zona glomerulosa function. Life Sci 1984 0.75
107 [Nle4, D-Phe7]-alpha-MSH: a superpotent melanotropin with prolonged action on vertebrate chromatophores. Comp Biochem Physiol A Comp Physiol 1985 0.75