Alain Lepape

Author PubWeight™ 73.00‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A 2009 4.23
2 Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med 2008 2.93
3 De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial. Intensive Care Med 2014 2.77
4 Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 2006 2.56
5 Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes. Crit Care Med 2004 2.51
6 Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2008 2.34
7 Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003 2.32
8 Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med 2010 2.31
9 Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Crit Care Med 2005 2.07
10 Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit Care 2011 1.78
11 Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients. Intensive Care Med 2009 1.69
12 Decreased T-cell repertoire diversity in sepsis: a preliminary study. Crit Care Med 2013 1.62
13 Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients. Int Immunopharmacol 2011 1.60
14 Clinical and therapeutic features of nonpostoperative nosocomial intra-abdominal infections. Ann Surg 2004 1.57
15 Delayed increase of S100A9 messenger RNA predicts hospital-acquired infection after septic shock. Crit Care Med 2011 1.47
16 Ethanol lock and risk of hemodialysis catheter infection in critically ill patients. A randomized controlled trial. Am J Respir Crit Care Med 2015 1.44
17 Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J Immunol 2006 1.41
18 IL-7 restores lymphocyte functions in septic patients. J Immunol 2012 1.39
19 Early assessment of leukocyte alterations at diagnosis of septic shock. Shock 2010 1.37
20 The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol Lett 2004 1.37
21 Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study. Immunol Lett 2006 1.36
22 Clinical and microbiological profiles of community-acquired and nosocomial intra-abdominal infections: results of the French prospective, observational EBIIA study. J Antimicrob Chemother 2009 1.30
23 Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock. Clin Chem 2002 1.20
24 Both percentage of gammadelta T lymphocytes and CD3 expression are reduced during septic shock. Crit Care Med 2005 1.18
25 Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults. Am J Respir Crit Care Med 2012 1.16
26 Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression. J Immunol 2008 1.09
27 Compliance with guidelines on antibiotic prophylaxis in total hip replacement surgery: results of a retrospective study of 416 patients in a teaching hospital. Infect Control Hosp Epidemiol 2004 1.02
28 Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric). Intensive Care Med 2015 0.98
29 Early- and late-onset ventilator-associated pneumonia acquired in the intensive care unit: comparison of risk factors. J Crit Care 2007 0.97
30 Development and validation of a questionnaire for quantitative assessment of perceived discomforts in critically ill patients. Intensive Care Med 2010 0.97
31 Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions. Crit Care 2011 0.97
32 mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Crit Care 2011 0.96
33 Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples. Cytometry B Clin Cytom 2012 0.96
34 Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock. Crit Care 2013 0.94
35 Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clin Immunol 2005 0.93
36 Prevention of ventilator-associated pneumonia in intensive care units: an international online survey. Antimicrob Resist Infect Control 2013 0.93
37 Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients. Crit Care 2010 0.92
38 Family participation in care to the critically ill: opinions of families and staff. Intensive Care Med 2003 0.92
39 Nosocomial infection after septic shock among intensive care unit patients. Infect Control Hosp Epidemiol 2008 0.91
40 Estimating attributable mortality due to nosocomial infections acquired in intensive care units. Infect Control Hosp Epidemiol 2010 0.89
41 Early-onset ventilator-associated pneumonia incidence in intensive care units: a surveillance-based study. BMC Infect Dis 2011 0.87
42 Early and dynamic changes in gene expression in septic shock patients: a genome-wide approach. Intensive Care Med Exp 2014 0.85
43 Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival. Crit Care Med 2007 0.85
44 The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock. Clin Immunol 2004 0.84
45 Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units. Crit Care 2011 0.84
46 Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils. Intensive Care Med 2003 0.84
47 Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients. Intensive Care Med 2014 0.82
48 Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery. Bioconjug Chem 2013 0.81
49 Fast renal trapping of porcine luteinizing hormone (pLH) shown by 123I-scintigraphic imaging in rats explains its short circulatory half-life. Reprod Biol Endocrinol 2003 0.81
50 Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1. Clin Chem Lab Med 2010 0.80
51 A dynamic view of mHLA-DR expression in management of severe septic patients. Crit Care 2011 0.80
52 Innovative therapeutic strategies for restoring lymphocyte functions in septic patients. Inflamm Allergy Drug Targets 2008 0.80
53 Persistent high level of circulating midregional-proadrenomedullin and increased risk of nosocomial infections after septic shock. J Trauma Acute Care Surg 2012 0.79
54 Reduction of urinary tract infections acquired in an intensive care unit during a 10-year surveillance program. Eur J Epidemiol 2008 0.79
55 Identification of biomarkers of response to IFNg during endotoxin tolerance: application to septic shock. PLoS One 2013 0.78
56 Increased MerTK expression in circulating innate immune cells of patients with septic shock. Intensive Care Med 2013 0.78
57 Assessment of a novel flow cytometry technique of one-step intracellular staining: example of FOXP3 in clinical samples. Cytometry B Clin Cytom 2013 0.76
58 Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial. Trials 2013 0.75
59 Relevance of blood cultures in acute pyelonephritis in a single-center retrospective study. Intern Emerg Med 2015 0.75
60 Effect of standardized surveillance of intensive care unit-acquired infections on ventilator-associated pneumonia incidence. Infect Control Hosp Epidemiol 2014 0.75