Published in Mol Immunol on October 27, 2011
Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More? Front Immunol (2015) 0.90
Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE. J Clin Endocrinol Metab (2014) 0.84
Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases. J Clin Invest (2016) 0.83
Regulations of gene expression in medullary thymic epithelial cells required for preventing the onset of autoimmune diseases. Front Immunol (2013) 0.83
The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance. Front Immunol (2015) 0.82
DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells. BMC Immunol (2012) 0.79
The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus. PLoS One (2015) 0.76
Transcriptional programs that control expression of the autoimmune regulator gene Aire. Nat Immunol (2016) 0.75
Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. Front Immunol (2016) 0.75
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis. Int J Mol Sci (2016) 0.75
Estrogen turns down "the AIRE". J Clin Invest (2016) 0.75
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma. Oncotarget (2017) 0.75
Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics (2005) 10.64
Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart. J Thorac Oncol (2015) 5.83
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med (2005) 4.06
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med (2010) 3.93
Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases. J Thorac Oncol (2012) 3.45
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet (2011) 3.41
Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol (2009) 3.13
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56
Comparison of oncologic outcomes for open and laparoscopic nephroureterectomy: a multi-institutional analysis of 1249 cases. Eur Urol (2009) 2.55
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med (2004) 2.43
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood (2011) 2.25
Statistical modeling of sequencing errors in SAGE libraries. Bioinformatics (2004) 2.25
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med (2004) 2.23
The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep (2008) 2.22
Assessment of the minimum number of lymph nodes needed to detect lymph node invasion at radical nephroureterectomy in patients with upper tract urothelial cancer. Urology (2009) 2.17
Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics (2008) 2.14
Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J Clin Oncol (2004) 2.11
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07
Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med (2003) 2.01
Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med (2008) 2.01
Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med (2006) 1.98
TFAP2E-DKK4 and chemoresistance in colorectal cancer. N Engl J Med (2012) 1.94
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov (2013) 1.93
New WHO histologic classification predicts prognosis of thymic epithelial tumors: a clinicopathologic study of 200 thymoma cases from China. Cancer (2002) 1.93
MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol (2009) 1.92
Tumour necrosis is an indicator of aggressive biology in patients with urothelial carcinoma of the upper urinary tract. Eur Urol (2009) 1.92
Desmoid tumors: clinical features and treatment options for advanced disease. Oncologist (2011) 1.90
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. J Exp Med (2009) 1.87
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci U S A (2008) 1.83
Redefining epithelial progenitor potential in the developing thymus. Eur J Immunol (2007) 1.81
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Lymphotoxin pathway directs thymic Aire expression. Nat Immunol (2003) 1.79
The extent of lymphadenectomy seems to be associated with better survival in patients with nonmetastatic upper-tract urothelial carcinoma: how many lymph nodes should be removed? Eur Urol (2009) 1.78
Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence. Int J Cancer (2010) 1.76
Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie (2010) 1.73
Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. Eur J Immunol (2007) 1.67
Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin. Hum Mutat (2004) 1.61
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells. Eur J Immunol (2014) 1.59
The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum Mol Genet (2002) 1.58
Atheroprotective effects of neuronal nitric oxide synthase in apolipoprotein e knockout mice. Arterioscler Thromb Vasc Biol (2006) 1.58
Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test. Arch Pathol Lab Med (2012) 1.53
A comparative analysis of algorithms for somatic SNV detection in cancer. Bioinformatics (2013) 1.51
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. J Thorac Oncol (2015) 1.50
Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci (2007) 1.47
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A (2006) 1.47
Mapping molecular motions leading to charge delocalization with ultrabright electrons. Nature (2013) 1.47
A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery. J Immunol (2008) 1.46
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature (2007) 1.46
The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46
Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions. Onkologie (2012) 1.43
Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. J Immunol (2009) 1.43
Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032-1039. J Immunol (2016) 1.40
MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4. J Biol Chem (2011) 1.40
Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor--report of two cases with similar morphology. Diagn Pathol (2007) 1.40
Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy. J Clin Oncol (2011) 1.38
ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting. J Thorac Oncol (2014) 1.37
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nat Immunol (2011) 1.36
Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J Immunol (2009) 1.32
Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). Gene (2003) 1.31
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells. Eur J Immunol (2007) 1.31
Juvenile-like (inflammatory/hyperplastic) mucosal polyps of the gastrointestinal tract in neurofibromatosis type 1. Histopathology (2014) 1.31
No evidence for a pathogenic role of human papillomavirus infection in ocular surface squamous neoplasia in Germany. Curr Eye Res (2009) 1.30
Thymoma and thymic carcinoma: an update of the WHO Classification 2004. Surg Today (2005) 1.29
Cetuximab-based treatment of metastatic anal cancer: correlation of response with KRAS mutational status. Oncology (2009) 1.27
How thymic antigen presenting cells sample the body's self-antigens. Curr Opin Immunol (2010) 1.26
Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood (2004) 1.26
Spliceosome mutations in hematopoietic malignancies. Nat Genet (2011) 1.23
Impact of tumor location on prognosis for patients with upper tract urothelial carcinoma managed by radical nephroureterectomy. Eur Urol (2009) 1.21
The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis. Hepatology (2009) 1.21
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest (2011) 1.21
The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. Autoimmun Rev (2013) 1.21
The impact of thymoma histotype on prognosis in a worldwide database. J Thorac Oncol (2015) 1.20
Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG. Ann Neurol (2005) 1.20
Deep sequencing analysis of the developing mouse brain reveals a novel microRNA. BMC Genomics (2011) 1.19
Mutations in the TMPRSS3 gene are a rare cause of childhood nonsyndromic deafness in Caucasian patients. J Mol Med (Berl) (2001) 1.19
Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure (2006) 1.19
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. Ann Neurol (2012) 1.19