Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMC 3246046)

Published in J Mol Cell Cardiol on October 23, 2011

Authors

Maike Krenz1, Ronald J Korthuis

Author Affiliations

1: Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA.

Articles citing this

The good, the bad, and the ugly with alcohol use and abuse on the heart. Alcohol Clin Exp Res (2013) 1.68

Alcohol consumption mitigates apoptosis and mammalian target of rapamycin signaling in myocardium. J Am Coll Surg (2014) 1.44

Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance. Prog Neurobiol (2014) 1.13

Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport. Pharmacol Ther (2012) 1.01

Alcoholism: a systemic proinflammatory condition. World J Gastroenterol (2014) 0.96

Acute alcohol modulates cardiac function as PI3K/Akt regulates oxidative stress. Alcohol Clin Exp Res (2014) 0.87

Cardiovascular risks and benefits of moderate and heavy alcohol consumption. Nat Rev Cardiol (2015) 0.87

Alcohol and cardiovascular disease--modulation of vascular cell function. Nutrients (2012) 0.87

Intake of red wine in different meals modulates oxidized LDL level, oxidative and inflammatory gene expression in healthy people: a randomized crossover trial. Oxid Med Cell Longev (2014) 0.83

Anti-inflammatory properties of lipoxin A4 protect against diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury. Neural Regen Res (2016) 0.82

Chronic Voluntary Ethanol Consumption Induces Favorable Ceramide Profiles in Selectively Bred Alcohol-Preferring (P) Rats. PLoS One (2015) 0.81

Ethanol promotes new vessel growth in remote nonischemic myocardium. J Surg Res (2014) 0.78

Ischemia/Reperfusion. Compr Physiol (2016) 0.78

Impact of Modifiable Risk Factors on B-type Natriuretic Peptide and Cardiac Troponin T Concentrations. Am J Cardiol (2015) 0.77

Access to alcohol and heart disease among patients in hospital: observational cohort study using differences in alcohol sales laws. BMJ (2016) 0.77

A daily glass of red wine associated with lifestyle changes independently improves blood lipids in patients with carotid arteriosclerosis: results from a randomized controlled trial. Nutr J (2013) 0.76

The associations of alcohol, coffee and tobacco consumption with gait in a community-dwelling population. Eur J Clin Nutr (2015) 0.76

A daily glass of red wine and lifestyle changes do not affect arterial blood pressure and heart rate in patients with carotid arteriosclerosis after 4 and 20 weeks. Cerebrovasc Dis Extra (2013) 0.76

Impact of chronic low to moderate alcohol consumption on blood lipid and heart energy profile in acetaldehyde dehydrogenase 2-deficient mice. Acta Pharmacol Sin (2014) 0.75

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function. Evid Based Complement Alternat Med (2015) 0.75

Alcohol withdrawal prevention: a randomized evaluation of lorazepam and ethanol--a pilot study. Am J Crit Care (2013) 0.75

On the use of carnosine and antioxidants: A letter from Russia. J Intercult Ethnopharmacol (2016) 0.75

Food and Drug Interactions. J Lifestyle Med (2017) 0.75

The Effect of Alcohol Administration on the Corpus Cavernosum. World J Mens Health (2016) 0.75

Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. Biomolecules (2016) 0.75

Ethanol attenuates peripheral NMDAR-mediated vascular oxidative stress and pressor response. Alcohol (2015) 0.75

Effect of Low-Dose Alcohol Consumption on Inflammation Following Transient Focal Cerebral Ischemia in Rats. Sci Rep (2017) 0.75

Alcoholic cardiomyopathy: Disrupted protein balance and impaired cardiomyocyte contractility. Alcohol Clin Exp Res (2017) 0.75

Alcohol's Effects on the Cardiovascular System. Alcohol Res (2017) 0.75

Articles cited by this

(truncated to the top 100)

Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet (2004) 42.12

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation (1986) 19.82

Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet (1992) 11.12

Prospective study of alcohol consumption and risk of coronary disease in men. Lancet (1991) 8.64

Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2010) 6.93

Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors. BMJ (1994) 6.74

Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ (2011) 6.11

Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med (2003) 5.95

Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology (1979) 5.73

Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med (2006) 5.34

Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med (1993) 5.19

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science (2008) 4.32

Alcohol consumption and mortality among women. N Engl J Med (1995) 4.22

Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ (1999) 4.14

Cytoprotection by prostaglandins. Gastroenterology (1979) 4.04

Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator. JAMA (1994) 3.86

Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev (2003) 3.83

Alcohol and coronary heart disease: a meta-analysis. Addiction (2000) 3.72

A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med (1988) 3.33

Primary prevention of stroke by healthy lifestyle. Circulation (2008) 3.32

Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care (2005) 3.19

Patterns of alcohol consumption and ischaemic heart disease in culturally divergent countries: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). BMJ (2010) 2.97

Cardiovascular risk factors and confounders among nondrinking and moderate-drinking U.S. adults. Am J Prev Med (2005) 2.88

Prevention of cardiovascular risk by moderate alcohol consumption: epidemiologic evidence and plausible mechanisms. Intern Emerg Med (2010) 2.84

Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ (2011) 2.62

Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med (2000) 2.57

To drink or not to drink? That is the question. Circulation (2007) 2.55

Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol (2007) 2.52

Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study. Stroke (2005) 2.51

Alcohol consumption and the risk of morbidity and mortality for different stroke types--a systematic review and meta-analysis. BMC Public Health (2010) 2.42

Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol (2010) 2.34

Functional limitations, socioeconomic status, and all-cause mortality in moderate alcohol drinkers. J Am Geriatr Soc (2009) 2.33

Alcohol consumption and risk for coronary heart disease among men with hypertension. Ann Intern Med (2007) 2.30

Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. Circulation (2005) 2.29

Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care (2004) 2.24

Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA (2002) 2.19

Alcohol and ischaemic heart disease: probably no free lunch. Lancet (2005) 2.18

Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles. Arch Intern Med (2006) 2.10

Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol (1983) 2.10

Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J Physiol (2006) 2.07

Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. Circulation (2009) 2.03

Prospective study of alcohol consumption and risk of dementia in older adults. JAMA (2003) 1.98

Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. BMJ (2009) 1.97

Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study. Circulation (2005) 1.96

Risk of cardiovascular mortality in alcohol drinkers, ex-drinkers and nondrinkers. Am J Cardiol (1990) 1.90

Primary and secondary prevention of cardiovascular diseases: a practical evidence-based approach. Mayo Clin Proc (2009) 1.88

Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology (1998) 1.81

Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res (2006) 1.78

Alcohol consumption and risk of heart failure in the Physicians' Health Study I. Circulation (2006) 1.68

Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am J Physiol (1983) 1.68

Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. Am J Physiol Heart Circ Physiol (2007) 1.65

Alcohol consumption and plasma concentration of C-reactive protein. Circulation (2003) 1.60

Prospective study of moderate alcohol consumption and mortality in US male physicians. Arch Intern Med (1997) 1.58

Alcohol metabolism and cancer risk. Alcohol Res Health (2007) 1.55

Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies. Alcohol Clin Exp Res (2008) 1.55

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J (2010) 1.54

Alcohol consumption and mortality in patients with cardiovascular disease: a meta-analysis. J Am Coll Cardiol (2010) 1.50

Acute ethanol exposure fails to elicit preconditioning-like protection in in situ rabbit hearts because of its continued presence during ischemia. J Am Coll Cardiol (2001) 1.49

Alcohol consumption before myocardial infarction. Results from the Kaiser-Permanente epidemiologic study of myocardial infarction. Ann Intern Med (1974) 1.49

Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction. J Clin Invest (1995) 1.46

Role of calcitonin gene-related peptide in the postischemic anti-inflammatory effects of antecedent ethanol ingestion. Am J Physiol Heart Circ Physiol (2005) 1.46

Vascular basis for brain degeneration: faltering controls and risk factors for dementia. Nutr Rev (2010) 1.44

Effects of moderate alcohol consumption on platelet aggregation, fibrinolysis, and blood lipids. Metabolism (1987) 1.44

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol (2008) 1.44

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci (2007) 1.43

Dose-response relationships of the protective and antiprotective effects of acute ethanol exposure in isolated rabbit hearts. Heart Dis (2002) 1.42

Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther (2010) 1.41

Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation (1995) 1.37

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther (2009) 1.33

Exposure-dependent effects of ethanol on the innate immune system. Alcohol (2008) 1.32

Alcohol and the cardiovascular system: research challenges and opportunities. J Am Coll Cardiol (2005) 1.32

Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol (2004) 1.30

Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. Eur J Clin Nutr (2002) 1.27

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice. J Mol Cell Cardiol (2009) 1.27

Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci U S A (2009) 1.25

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival. Am J Physiol Heart Circ Physiol (2010) 1.25

Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proc Natl Acad Sci U S A (1999) 1.23

Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol (2010) 1.23

Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC study. Ann Epidemiol (2007) 1.23

Retracted Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med (2008) 1.22

Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes. Am J Physiol Heart Circ Physiol (2002) 1.20

Resveratrol: a cardioprotective substance. Ann N Y Acad Sci (2011) 1.18

Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial. Diabetologia (2008) 1.18

Ethanol and cognition: indirect effects, neurotoxicity and neuroprotection: a review. Int J Environ Res Public Health (2010) 1.18

Alcohol consumption and heart failure: a systematic review. Curr Atheroscler Rep (2008) 1.17

Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt. Am J Physiol Heart Circ Physiol (2002) 1.16

The effect of evening alcohol consumption on next-morning glucose control in type 1 diabetes. Diabetes Care (2001) 1.15

Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial. Am J Clin Nutr (2007) 1.14

Alcohol consumption, physical activity, and chronic disease risk factors: a population-based cross-sectional survey. BMC Public Health (2006) 1.14

Effects of ethanol intake on lipoproteins and atherosclerosis. Curr Opin Lipidol (2010) 1.13

The second window of preconditioning (SWOP) where are we now? Cardiovasc Drugs Ther (2010) 1.12

Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. Free Radic Biol Med (2003) 1.12

Alcohol and platelet aggregation: the Caerphilly Prospective Heart Disease Study. Am J Clin Nutr (1992) 1.11

5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol (2006) 1.08

Modulation of endogenous antioxidant system by wine polyphenols in human disease. Clin Chim Acta (2010) 1.07

Relationship of alcohol intake with blood pressure in young adults. Hypertension (1995) 1.07

Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels. Am J Physiol Heart Circ Physiol (2010) 1.06

Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica. Am J Clin Nutr (2005) 1.06

Alcoholic liver injury: influence of gender and hormones. World J Gastroenterol (2010) 1.06

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med (2007) 1.06

Articles by these authors

Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol (2012) 2.24

Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res (2006) 1.78

Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies. Alcohol Clin Exp Res (2008) 1.55

Role of calcitonin gene-related peptide in the postischemic anti-inflammatory effects of antecedent ethanol ingestion. Am J Physiol Heart Circ Physiol (2005) 1.46

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival. Am J Physiol Heart Circ Physiol (2010) 1.25

Heterogeneity in function of small artery smooth muscle BKCa: involvement of the beta1-subunit. J Physiol (2009) 1.21

Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. Free Radic Biol Med (2003) 1.12

5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol (2006) 1.08

Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of BK channels. Am J Physiol Heart Circ Physiol (2010) 1.06

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic Biol Med (2007) 1.06

Hydrogen sulfide preconditioning or neutrophil depletion attenuates ischemia-reperfusion-induced mitochondrial dysfunction in rat small intestine. Am J Physiol Gastrointest Liver Physiol (2011) 1.01

Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanism. Am J Physiol Heart Circ Physiol (2009) 1.00

AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase. Microcirculation (2009) 0.97

Preconditioning with ethanol prevents postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol (2002) 0.93

Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of heme oxygenase-1. Am J Physiol Heart Circ Physiol (2011) 0.91

Mechanisms underlying regional differences in the Ca2+ sensitivity of BK(Ca) current in arteriolar smooth muscle. J Physiol (2013) 0.89

Antecedent ethanol ingestion prevents postischemic microvascular dysfunction. Pathophysiology (2004) 0.89

Heme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation. J Pharmacol Exp Ther (2010) 0.89

Role of eNOS-derived NO in the postischemic anti-inflammatory effects of antecedent ethanol ingestion in murine small intestine. Am J Physiol Heart Circ Physiol (2006) 0.88

Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration. J Nutr Biochem (2008) 0.85

Angiotensin II mediates postischemic leukocyte-endothelial interactions: role of calcitonin gene-related peptide. Am J Physiol Heart Circ Physiol (2007) 0.84

Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol (2011) 0.84

Bradykinin-induced proinflammatory signaling mechanisms. Am J Physiol Heart Circ Physiol (2002) 0.83

Antecedent ethanol ingestion prevents postischemic P-selectin expression in murine small intestine. Microcirculation (2004) 0.82

Late preconditioning by ethanol is initiated via an oxidant-dependent signaling pathway. Free Radic Biol Med (2003) 0.82

Antecedent ethanol ingestion prevents postischemic leukocyte adhesion and P-selectin expression by a protein kinase C-dependent mechanism. Dig Dis Sci (2005) 0.81

Antecedent ethanol attenuates cerebral ischemia/reperfusion-induced leukocyte-endothelial adhesive interactions and delayed neuronal death: role of large conductance, Ca2+-activated K+ channels. Microcirculation (2010) 0.81

Mast Cell Proteases and Inflammation. Drug Discov Today Dis Models (2011) 0.80

Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice. Am J Physiol Heart Circ Physiol (2013) 0.80

β1-integrin is essential for vasoregulation and smooth muscle survival in vivo. Arterioscler Thromb Vasc Biol (2013) 0.79

Heme oxygenase-1: a pluripotent sentinel limiting the systemic inflammatory response to extremity ischemia and reperfusion. Crit Care Med (2005) 0.79

Ischemic preconditioning prevents postischemic arteriolar, capillary, and postcapillary venular dysfunction: signaling pathways mediating the adaptive metamorphosis to a protected phenotype in preconditioned endothelium. Microcirculation (2002) 0.78

Vascular receptors as new substrates for matrix metalloproteinases in hypertension and other inflammatory states. Am J Physiol Heart Circ Physiol (2010) 0.77

Introduction to the special topics issue on alcohol and cardioprotection. Pathophysiology (2004) 0.77

TRPing up reperfusion: neutrophil TRPM2 channels exacerbate necrosis and contractile dysfunction in post-ischaemic myocardium. Cardiovasc Res (2012) 0.75

Filling GAPs in the understanding of cardioprotection induced by GPCR activation: RGS proteins modulate ischaemic injury. Cardiovasc Res (2011) 0.75