Published in Toxins (Basel) on October 20, 2011
Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A (2012) 0.99
Cytoskeleton as an emerging target of anthrax toxins. Toxins (Basel) (2012) 0.86
Targeting Rho-GTPases in immune cell migration and inflammation. Br J Pharmacol (2014) 0.85
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Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions. PLoS One (2013) 0.84
Does Bacillus anthracis Lethal Toxin Directly Depress Myocardial Function? A Review of Clinical Cases and Preclinical Studies. Toxins (Basel) (2015) 0.77
Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax. Toxins (Basel) (2015) 0.77
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Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States. Emerg Infect Dis (2001) 11.73
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (1998) 10.53
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A (1982) 10.36
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol (2001) 4.74
The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci (2008) 4.40
Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev (2004) 4.12
Raxibacumab for the treatment of inhalational anthrax. N Engl J Med (2009) 3.91
Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice. J Clin Invest (2003) 3.57
Rho kinases in cardiovascular physiology and pathophysiology. Circ Res (2006) 2.97
The roles of anthrax toxin in pathogenesis. Curr Opin Microbiol (2004) 2.89
Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state. J Biol Chem (2005) 2.59
Optimized production and purification of Bacillus anthracis lethal factor. Protein Expr Purif (2000) 2.52
Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A (2009) 2.22
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Quantitative pathology of inhalational anthrax I: quantitative microscopic findings. Mod Pathol (2001) 2.10
Bacterial cytotoxins: targeting eukaryotic switches. Nat Rev Microbiol (2005) 1.98
Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.97
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Manipulation of host signalling pathways by anthrax toxins. Biochem J (2007) 1.85
Anthrax lethal factor inhibition. Proc Natl Acad Sci U S A (2005) 1.83
Anthrax lethal toxin induces endothelial barrier dysfunction. Am J Pathol (2005) 1.81
Production, recovery and immunogenicity of the protective antigen from a recombinant strain of Bacillus anthracis. J Ind Microbiol Biotechnol (2002) 1.75
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TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia. J Biol Chem (2008) 1.55
A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor. Clin Infect Dis (2007) 1.51
The role of cytoskeleton in the regulation of vascular endothelial barrier function. Microvasc Res (2008) 1.44
Sepsis and pathophysiology of anthrax in a nonhuman primate model. Am J Pathol (2006) 1.39
Contribution of toxins to the pathogenesis of inhalational anthrax. Cell Microbiol (2007) 1.38
Interactions between anthrax toxin receptors and protective antigen. Curr Opin Microbiol (2005) 1.38
Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage. Microb Pathog (2007) 1.36
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog (2009) 1.30
Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease. Trends Pharmacol Sci (2011) 1.17
Pathology of inhalational anthrax infection in the african green monkey. Vet Pathol (2007) 1.14
Ratio of lethal and edema factors in rabbit systemic anthrax. Toxicon (2008) 1.14
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Proc Natl Acad Sci U S A (2008) 1.08
Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins. Blood (2007) 1.07
Discovery of the anthrax toxin: the beginning of studies of virulence determinants regulated in vivo. Int J Med Microbiol (2002) 0.95
Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity. Cell Microbiol (2010) 0.93
Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism. J Immunol (2008) 0.92
Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability. Infect Immun (2009) 0.92
Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy. BMC Cell Biol (2007) 0.89
Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells. J Neurosci Res (2005) 0.88
The role of RhoA/Rho kinase pathway in endothelial dysfunction. J Cardiovasc Dis Res (2010) 0.83
Quantitative analysis of the effect of cell type and cellular differentiation on protective antigen binding to human target cells. FEBS Lett (2006) 0.82
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest (2012) 2.19
Cellular prion protein is expressed on endothelial cells and is released during apoptosis on membrane microparticles found in human plasma. Transfusion (2002) 2.18
Anthrax lethal toxin induces endothelial barrier dysfunction. Am J Pathol (2005) 1.81
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest (2009) 1.77
First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opin Biol Ther (2007) 1.13
Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J Pharmacol Exp Ther (2007) 1.11
Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design. Trends Mol Med (2010) 1.09
Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectives. Antioxid Redox Signal (2010) 1.07
Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin. Antioxid Redox Signal (2010) 0.95
Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism. J Immunol (2008) 0.92
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol (2011) 0.92
Anthrax lethal toxin enhances cytokine-induced VCAM-1 expression on human endothelial cells. Biochem Biophys Res Commun (2005) 0.83
Sodium nitrite induces acute central nervous system toxicity in guinea pigs exposed to systemic cell-free hemoglobin. Biochem Biophys Res Commun (2011) 0.79
Anthrax lethal toxin enhances IkappaB kinase activation and differentially regulates pro-inflammatory genes in human endothelium. J Biol Chem (2009) 0.78
The large clostridial toxins from Clostridium sordellii and C. difficile repress glucocorticoid receptor activity. Infect Immun (2007) 0.78