Published in Immunity on November 10, 2011
Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity (2012) 2.69
Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol (2015) 1.66
RNA recognition by human TLR8 can lead to autoimmune inflammation. J Exp Med (2013) 1.64
UNC93B1 mediates differential trafficking of endosomal TLRs. Elife (2013) 1.61
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
The genome sequence of Leishmania (Leishmania) amazonensis: functional annotation and extended analysis of gene models. DNA Res (2013) 1.06
Trafficking of endosomal Toll-like receptors. Trends Cell Biol (2014) 1.03
Defining the subcellular sites of innate immune signal transduction. Trends Immunol (2012) 1.02
Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Nat Immunol (2015) 0.99
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem (2012) 0.92
TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J (2014) 0.92
Cofactors required for TLR7- and TLR9-dependent innate immune responses. Cell Host Microbe (2012) 0.91
Molecular mechanisms of regulation of Toll-like receptor signaling. J Leukoc Biol (2016) 0.89
Emerging principles governing signal transduction by pattern-recognition receptors. Cold Spring Harb Perspect Biol (2014) 0.85
The ectodomain of TLR3 receptor is required for its plasma membrane translocation. PLoS One (2014) 0.80
UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5. Proc Natl Acad Sci U S A (2014) 0.80
Spontaneous activation of RNA-sensing pathways in autoimmune disease. Curr Opin Immunol (2013) 0.78
Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance. Cell Mol Life Sci (2015) 0.78
TLR9 re-expression in cancer cells extends the S-phase and stabilizes p16(INK4a) protein expression. Oncogenesis (2016) 0.78
TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Complex Negative Regulation of TLR9 by Multiple Proteolytic Cleavage Events. J Immunol (2016) 0.75
Innate immunity: TLR9 mutations reveal a new level of self tolerance. Nat Rev Immunol (2011) 0.75
Traditional biochemical assays for studying toll-like receptor 9. J Immunoassay Immunochem (2013) 0.75
DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori. Curr Top Microbiol Immunol (2017) 0.75
Toll-like receptors. Annu Rev Immunol (2001) 26.06
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature (2002) 11.05
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88
TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol (2004) 8.06
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science (2004) 6.07
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol (2006) 6.00
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med (2008) 5.97
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 5.15
Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet (2000) 4.98
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30
A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol (2009) 4.19
Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol (2007) 4.09
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature (2008) 3.93
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J Exp Med (2005) 3.21
Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet (2001) 3.21
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol (2004) 3.18
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol (2006) 3.16
Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med (1998) 3.01
Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity (2009) 2.86
TLR9 is localized in the endoplasmic reticulum prior to stimulation. J Immunol (2004) 2.68
Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature (1986) 2.64
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. J Exp Med (2004) 2.42
Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proc Natl Acad Sci U S A (1985) 2.33
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med (2011) 1.93
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest (2011) 1.75
Impairment of T and B cell development by treatment with a type I interferon. J Exp Med (1998) 1.54
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A (2010) 1.50
Cytoplasmic targeting motifs control localization of toll-like receptor 9. J Biol Chem (2006) 1.22
Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. Proc Natl Acad Sci U S A (1991) 1.20
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Nucleic acid recognition by the innate immune system. Annu Rev Immunol (2011) 4.00
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature (2008) 3.93
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell (2011) 3.00
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med (2009) 2.92
TLR signaling is required for Salmonella typhimurium virulence. Cell (2011) 2.88
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med (2011) 1.93
The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature (2013) 1.86
UNC93B1 mediates differential trafficking of endosomal TLRs. Elife (2013) 1.61
Toll-like receptors: key players in antiviral immunity. Curr Opin Virol (2011) 1.24
Selective ligand recognition by a diversity-generating retroelement variable protein. PLoS Biol (2008) 1.17
Diversity-generating retroelement homing regenerates target sequences for repeated rounds of codon rewriting and protein diversification. Mol Cell (2008) 1.14
Methods of detection of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in periodontal microbiology, with special emphasis on advanced molecular techniques: a review. J Clin Periodontol (2004) 1.13
Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05
Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol (2004) 1.01
Nucleic acid sensing Toll-like receptors in autoimmunity. Curr Opin Immunol (2010) 0.94
Cofactors required for TLR7- and TLR9-dependent innate immune responses. Cell Host Microbe (2012) 0.91
Quantitative real-time PCR based on single copy gene sequence for detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. J Periodontal Res (2003) 0.91
Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90
Compartment-specific control of signaling from a DNA-sensing immune receptor. Sci Signal (2010) 0.90
Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus. J Immunol (2011) 0.88
Vagotomy attenuates brain cytokines and sleep induced by peripherally administered tumor necrosis factor-α and lipopolysaccharide in mice. Sleep (2013) 0.87
No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice. Nat Immunol (2013) 0.85
The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production. PLoS One (2012) 0.79
Unfolding new roles for XBP1 in immunity. Nat Immunol (2010) 0.77
The metabolic effects of low-carbohydrate diets and incorporation into a biochemistry course. Biochem Mol Biol Educ (2005) 0.77
The impact of Toll-like receptors on bacterial virulence strategies. Curr Opin Microbiol (2013) 0.77
Olfactory bulb and hypothalamic acute-phase responses to influenza virus: effects of immunization. Neuroimmunomodulation (2013) 0.76
MicroRNAs and LPS: developing a relationship in the neonatal gut. Cell Host Microbe (2010) 0.76
TLR5 stops commensals in their tracks. Cell Host Microbe (2013) 0.75