Published in PLoS One on November 07, 2011
Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR rats. Diabetol Metab Syndr (2014) 1.43
PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging (Albany NY) (2013) 0.88
Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect. Hepatology (2013) 0.86
Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway. PLoS One (2013) 0.85
High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. Endocrinology (2013) 0.80
Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. Eur J Nutr (2012) 0.78
DMH1 increases glucose metabolism through activating Akt in L6 rat skeletal muscle cells. PLoS One (2014) 0.78
Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. PLoS One (2014) 0.78
Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity. Aging (Albany NY) (2015) 0.77
Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. J Biol Chem (2015) 0.76
Differential retention and expansion of the ancestral genes associated with the paleopolyploidies in modern rosid plants, as revealed by analysis of the extensins super-gene family. BMC Genomics (2014) 0.76
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
Preparation of isolated rat liver cells. Methods Cell Biol (1976) 17.96
Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol (2006) 10.67
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97
Selective versus total insulin resistance: a pathogenic paradox. Cell Metab (2008) 5.25
Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest (1994) 5.12
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab (2007) 4.74
Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res (2004) 4.54
Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes (1988) 3.67
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res (2004) 3.62
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci U S A (1996) 3.50
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol (1992) 3.26
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell (2009) 2.61
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J Biol Chem (1997) 2.46
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem (2007) 2.36
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem (2004) 2.23
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J Biol Chem (2009) 2.21
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem (2007) 2.20
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes (1999) 2.14
Cantharidin-binding protein: identification as protein phosphatase 2A. Proc Natl Acad Sci U S A (1992) 1.80
Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett (1993) 1.61
Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy. Diabetes (2010) 1.53
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res (2009) 1.40
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol (2007) 1.35
A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev (2003) 1.31
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes (2001) 1.29
Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes. Am J Physiol Endocrinol Metab (2004) 1.21
Okadaic acid, useful tool for studying cellular processes. Curr Med Chem (2002) 1.14
The structural basis for tight control of PP2A methylation and function by LCMT-1. Mol Cell (2011) 1.13
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. Circulation (2004) 1.09
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Diabetologia (2008) 1.04
In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology (1983) 1.04
Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes. Acta Diabetol (2005) 1.04
PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: a mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment. Int J Oncol (2008) 0.95
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem (2010) 0.88
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes (2002) 4.14
Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab (2009) 2.05
Cerebral carbohydrate cost of physical exertion in humans. Am J Physiol Regul Integr Comp Physiol (2004) 1.77
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. Diabetes (2004) 1.75
Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. J Physiol (2009) 1.52
A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. J Physiol (2003) 1.42
Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation. Physiol Genomics (2006) 1.42
PGC-1alpha and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype. Am J Physiol Endocrinol Metab (2006) 1.21
The intent to exercise influences the cerebral O(2)/carbohydrate uptake ratio in humans. J Physiol (2002) 1.18
Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function. Diabetes (2006) 1.10
Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609. J Clin Endocrinol Metab (2008) 1.09
FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J (2011) 1.09
Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes (2006) 1.04
High glycogen levels in the hippocampus of patients with epilepsy. J Cereb Blood Flow Metab (2006) 1.03
Bicarbonate attenuates arterial desaturation during maximal exercise in humans. J Appl Physiol (1985) (2002) 1.03
Importance of the solvent-exposed residues of the insulin B chain alpha-helix for receptor binding. Biochemistry (2008) 1.00
A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther (2007) 1.00
Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline. J Physiol (2008) 0.97
Regulation of mitochondrial respiration by inorganic phosphate; comparing permeabilized muscle fibers and isolated mitochondria prepared from type-1 and type-2 rat skeletal muscle. Eur J Appl Physiol (2008) 0.97
Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. PLoS One (2009) 0.95
Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice. Diabetes (2013) 0.93
Mitochondrial function in skeletal muscle is normal and unrelated to insulin action in young men born with low birth weight. J Clin Endocrinol Metab (2008) 0.93
31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy. J Neurol (2007) 0.92
Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass. Am J Physiol Endocrinol Metab (2009) 0.91
Partly ordered synthesis and degradation of glycogen in cultured rat myotubes. J Biol Chem (2001) 0.89
A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine. J Biomed Sci (2010) 0.89
PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging (Albany NY) (2013) 0.88
Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of taurine. Pediatr Res (2010) 0.88
Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice. Eur J Pharmacol (2009) 0.88
Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects. Am J Physiol Endocrinol Metab (2011) 0.87
Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy. Neoplasia (2002) 0.86
MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip. J Appl Physiol (1985) (2006) 0.86
High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio. Proc Natl Acad Sci U S A (2011) 0.85
Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans. J Appl Physiol (1985) (2009) 0.85
Flux control analysis of mitochondrial oxidative phosphorylation in rat skeletal muscle: pyruvate and palmitoyl-carnitine as substrates give different control patterns. Eur J Appl Physiol (2007) 0.84
Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only. Am J Physiol Endocrinol Metab (2012) 0.83
Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscle. Muscle Nerve (2002) 0.83
Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol (2013) 0.83
ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. Obesity (Silver Spring) (2013) 0.82
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties. J Med Chem (2009) 0.82
Engineering of insulin receptor isoform-selective insulin analogues. PLoS One (2011) 0.82
Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver. BMC Dev Biol (2011) 0.82
Receptor-isoform-selective insulin analogues give tissue-preferential effects. Biochem J (2011) 0.82
Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: evaluation of the arterial and jugular venous metabolome. J Cereb Blood Flow Metab (2010) 0.81
Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance. Epilepsia (2014) 0.81
Changed mitochondrial function by pre- and/or postpartum diet alterations in sheep. Am J Physiol Endocrinol Metab (2009) 0.81
Quantitative evaluation of respiration induced metabolic oscillations in erythrocytes. Biophys Chem (2008) 0.81
Reduced gluconeogenesis and lactate clearance in Huntington's disease. Neurobiol Dis (2010) 0.80
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma. Cancer Res (2002) 0.80
Pre- and postnatal nutrition in sheep affects β-cell secretion and hypothalamic control. J Endocrinol (2013) 0.80
Blockades of mitogen-activated protein kinase and calcineurin both change fibre-type markers in skeletal muscle culture. Pflugers Arch (2002) 0.80
Effect of fuels on exercise capacity in muscle phosphoglycerate mutase deficiency. Arch Neurol (2005) 0.80
Recombinant adiponectin does not lower plasma glucose in animal models of type 2 diabetes. PLoS One (2012) 0.79
Adipose weight gain during chronic insulin treatment of mice results from changes in lipid storage without affecting de novo synthesis of palmitate. PLoS One (2013) 0.78
Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem (2008) 0.78
Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. PLoS One (2012) 0.78
The effect of hepatectomy on glucose homeostasis in pig and in man. J Hepatol (2002) 0.76
The effect of long-term taurine supplementation and fructose feeding on glucose and lipid homeostasis in Wistar rats. Adv Exp Med Biol (2013) 0.76
Acute and perinatal programming effects of a fat-rich diet on rat muscle mitochondrial function and hepatic lipid accumulation. Acta Obstet Gynecol Scand (2014) 0.76
Proteasome Inhibitor Bortezomib Enhances the Activity of Multiple Mutant Forms of Lysosomal α-Glucosidase in Pompe Disease. JIMD Rep (2014) 0.75
Brain glucose and lactate uptake during exhaustive exercise. J Physiol (2005) 0.75
Glycopyrrolate prevents extreme bradycardia and cerebral deoxygenation during electroconvulsive therapy. J ECT (2007) 0.75
Fructose feeding changes taurine homeostasis in wistar rats. Adv Exp Med Biol (2015) 0.75
Metabolism of perfused pig intercostal muscles evaluated by 31P-magnetic resonance spectroscopy. Exp Physiol (2006) 0.75
Effects of a high fat diet and taurine supplementation on metabolic parameters and skeletal muscle mitochondrial function in rats. Adv Exp Med Biol (2015) 0.75
Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha. Gene (2007) 0.75
[Unexpected increase of plasma lactate levels in extremely premature and growth-retarded newborns]. Ugeskr Laeger (2004) 0.75
[The muscles work, but the brain gets tired]. Ugeskr Laeger (2006) 0.75
Effects of electrostimulation on glycogenolysis in cultured rat myotubes. Pflugers Arch (2003) 0.75