Published in Hepatology on March 20, 2012
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med (2012) 1.50
Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function. Circ Cardiovasc Genet (2015) 1.39
Intracellular trafficking and secretion of VLDL. Arterioscler Thromb Vasc Biol (2012) 1.09
Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion. J Biomed Res (2014) 1.00
Lipotoxicity in the liver. World J Hepatol (2013) 0.97
Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice. J Biol Chem (2013) 0.92
Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice. J Lipid Res (2014) 0.83
Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia. J Lipid Res (2013) 0.81
Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice. J Lipid Res (2014) 0.81
Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide. J Biol Chem (2015) 0.78
MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study. BMC Med Genet (2015) 0.77
MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice. J Biol Chem (2016) 0.76
CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation. Proc Natl Acad Sci U S A (2017) 0.75
A rapid method of total lipid extraction and purification. Can J Biochem Physiol (1959) 173.74
Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation (2004) 20.67
Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res (2003) 2.88
Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res (2005) 2.61
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest (1999) 2.50
Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology (2005) 2.25
Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science (1992) 2.24
Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution. Biochemistry (2007) 1.94
Subcellular localization of B apoprotein of plasma lipoproteins in rat liver. J Cell Biol (1976) 1.81
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75
Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms. Proc Natl Acad Sci U S A (1995) 1.67
Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase. Prog Lipid Res (1989) 1.63
A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein. J Lipid Res (2004) 1.59
Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev (2009) 1.58
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med (2005) 1.57
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol (2007) 1.44
Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouse. J Biol Chem (1999) 1.44
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) (2010) 1.43
Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol (2008) 1.40
Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency. J Lipid Res (1998) 1.34
Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis. J Lipid Res (2004) 1.30
Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem (2002) 1.25
Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein. J Lipid Res (2005) 1.24
The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells. A unified model for the assembly of very low density lipoproteins. J Biol Chem (1999) 1.16
Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim Biophys Acta (2000) 1.15
Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins. J Biol Chem (2006) 1.11
Assembly of very low density lipoprotein: a two-step process of apolipoprotein B core lipidation. J Nutr (1999) 1.09
Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport. Biochemistry (1993) 1.05
The assembly of triacylglycerol-rich lipoproteins: an essential role for the microsomal triacylglycerol transfer protein. Br J Nutr (1998) 1.04
A Drosophila microsomal triglyceride transfer protein homolog promotes the assembly and secretion of human apolipoprotein B. Implications for human and insect transport and metabolism. J Biol Chem (2003) 1.03
A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein. J Biol Chem (2000) 1.03
Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein. Biochemistry (1994) 0.99
Current biology of MTP: implications for selective inhibition. Curr Top Med Chem (2005) 0.93
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
The immunology of mucosal models of inflammation. Annu Rev Immunol (2001) 9.08
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest (2008) 6.17
Microbial exposure during early life has persistent effects on natural killer T cell function. Science (2012) 5.90
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest (2004) 5.14
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity (2002) 4.60
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity (2002) 3.46
Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A (2005) 3.32
CEACAM1: contact-dependent control of immunity. Nat Rev Immunol (2006) 2.81
Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity (2004) 2.79
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med (2012) 2.58
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest (2006) 2.55
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Intestinal lipid absorption. Am J Physiol Endocrinol Metab (2009) 2.41
HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clin Chem (2011) 2.33
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med (2002) 2.32
Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study. BMJ (2012) 2.32
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med (2002) 2.22
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest (2006) 2.16
Paneth cells as a site of origin for intestinal inflammation. Nature (2013) 2.09
Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1. Arterioscler Thromb Vasc Biol (2013) 1.95
Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution. Biochemistry (2007) 1.94
Concern Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases. Proc Natl Acad Sci U S A (2006) 1.92
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology (2003) 1.91
A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model. Mol Ther (2003) 1.86
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology (2013) 1.83
Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A (2008) 1.82
Epithelial tight junctions in intestinal inflammation. Ann N Y Acad Sci (2009) 1.81
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med (2006) 1.78
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75
Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes. Curr Biol (2011) 1.74
Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors. Cancer Res (2002) 1.74
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A (2002) 1.73
An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology (2009) 1.71
LOCSVMPSI: a web server for subcellular localization of eukaryotic proteins using SVM and profile of PSI-BLAST. Nucleic Acids Res (2005) 1.70
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med (2013) 1.70
Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci U S A (2004) 1.69
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol (2009) 1.68
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein. J Lipid Res (2004) 1.59
Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem (2002) 1.58
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med (2005) 1.57
Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor. Mol Biol Cell (2004) 1.54
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med (2012) 1.50
Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol (2010) 1.50
Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood (2004) 1.49
Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest (2009) 1.49
CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med (2004) 1.49
Multiple functions of microsomal triglyceride transfer protein. Nutr Metab (Lond) (2012) 1.47
Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology (2003) 1.45
Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab (2010) 1.44
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A (2011) 1.44
A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity. Clin Cancer Res (2004) 1.44
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology (2006) 1.44
Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus. Mol Ther (2003) 1.43
Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J Biol Chem (2008) 1.40
Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol (2008) 1.40
Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation. J Biol Chem (2006) 1.39
Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery. Sci Transl Med (2013) 1.38
Clock is important for food and circadian regulation of macronutrient absorption in mice. J Lipid Res (2009) 1.36
Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis. Inflamm Bowel Dis (2002) 1.35
Construction and characterization of adenovirus serotype 5 packaged by serotype 3 hexon. J Virol (2002) 1.35
EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J Immunol (2005) 1.35
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med (2013) 1.34
CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J Immunol (2002) 1.34
The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol (2005) 1.34
Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease. Semin Immunol (2009) 1.33
Evidence for multiple complementary pathways for efficient cholesterol absorption in mice. J Lipid Res (2005) 1.33
SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity (2006) 1.33
Microsomal triglyceride transfer protein: a multifunctional protein. Front Biosci (2003) 1.33
Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics. Crit Rev Biotechnol (2013) 1.31
CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity. J Biol Chem (2007) 1.30
Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells. J Biol Chem (2003) 1.30
F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis. Thromb Haemost (2002) 1.29
Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Semin Immunopathol (2009) 1.29
Disrupted barrier function through epithelial cell apoptosis. Ann N Y Acad Sci (2006) 1.29
Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels. J Biol Chem (2007) 1.29
Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses. Mol Ther (2002) 1.28
Eosinophils alter colonic epithelial barrier function: role for major basic protein. Am J Physiol Gastrointest Liver Physiol (2005) 1.28
Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology (2003) 1.28
Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem (2003) 1.27
Crohn's disease: NOD2, autophagy and ER stress converge. Gut (2011) 1.27