Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 3294191)

Published in Genesis on January 30, 2012

Authors

Daniel Oropeza1, Marko Horb

Author Affiliations

1: Laboratory of Molecular Organogenesis, Institut de recherches cliniques de Montréal, Montreal, QC, Canada.

Articles cited by this

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21

Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development (2000) 4.71

The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47

Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell (2007) 2.68

Developmental biology of the pancreas: a comprehensive review. Dev Biol (2008) 2.59

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell (2011) 2.49

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev (2001) 2.29

Experimental conversion of liver to pancreas. Curr Biol (2003) 2.24

Rfx6 directs islet formation and insulin production in mice and humans. Nature (2010) 2.15

Pancreas and beta-cell development: from the actual to the possible. Development (2006) 2.13

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02

The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev (2006) 1.81

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation. Hepatology (2009) 1.80

Defining pancreatic endocrine precursors and their descendants. Diabetes (2007) 1.65

Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. Proc Natl Acad Sci U S A (2004) 1.58

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (2010) 1.43

Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. Genes Dev (2006) 1.43

Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration. Islets (2010) 1.36

How to make beta cells? Curr Opin Cell Biol (2009) 1.31

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development (2008) 1.30

The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20

Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol (2005) 1.16

The Xenopus tadpole gut: fate maps and morphogenetic movements. Development (2000) 1.16

Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev Biol (2007) 1.15

Gene targeting reveals a crucial role for MTG8 in the gut. Mol Cell Biol (2001) 1.14

Zebrafish pancreas development. Mol Cell Endocrinol (2009) 1.10

Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade. Differentiation (2007) 1.09

Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors. Stem Cells (2007) 1.05

Endoderm specification and differentiation in Xenopus embryos. Dev Biol (2001) 1.05

Development of the pancreas in Xenopus laevis. Dev Dyn (2000) 1.04

The MTG proteins: chromatin repression players with a passion for networking. Genomics (2004) 1.02

Development of the gut in Xenopus laevis. Dev Dyn (1998) 1.01

Xenopus pancreas development. Dev Dyn (2009) 0.99

Differentiation of embryonic stem cells conditionally expressing neurogenin 3. Stem Cells (2006) 0.98

Expression of amylase and other pancreatic genes in Xenopus. Mech Dev (2002) 0.98

The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds. Development (2009) 0.97

Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. Dev Biol (2011) 0.95

Promoting ectopic pancreatic fates: pancreas development and future diabetes therapies. Clin Genet (2008) 0.95

The expression and function of MTG/ETO family proteins during neurogenesis. Dev Biol (2005) 0.94

BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. Dev Biol (2010) 0.91

Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation. Mol Endocrinol (2010) 0.91

XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis. Mech Dev (2002) 0.89

Reprogramming into pancreatic endocrine cells based on developmental cues. Mol Cell Endocrinol (2009) 0.87

Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia. Rev Endocr Metab Disord (2010) 0.87

Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development. Dev Dyn (2009) 0.84

Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis. Mol Cell Neurosci (2009) 0.83

Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system. Neurosci Lett (2010) 0.78