Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 3264303)

Published in Infect Immun on November 28, 2011

Authors

Marcel Wüthrich1, Karen Ersland, John C Pick-Jacobs, Benjamin H Gern, Christopher A Frye, Thomas D Sullivan, Meghan B Brennan, Hanna I Filutowicz, Kevin O'Brien, Keegan D Korthauer, Stacey Schultz-Cherry, Bruce S Klein

Author Affiliations

1: Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA. mwuethri@wisc.edu

Articles cited by this

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol (2004) 36.25

Fluorescent proteins from nonbioluminescent Anthozoa species. Nat Biotechnol (1999) 14.64

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity (2007) 9.26

Initial T cell frequency dictates memory CD8+ T cell lineage commitment. Nat Immunol (2005) 5.83

Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity (2003) 5.52

The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity (1998) 5.20

Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity (2007) 4.92

Naive and memory CD4+ T cell survival controlled by clonal abundance. Science (2006) 4.67

Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J Mol Biol (1992) 4.13

Mouse model of pulmonary blastomycosis: utility, simplicity, and quantitative parameters. Am Rev Respir Dis (1978) 3.75

Immunity to fungal infections. Nat Rev Immunol (2004) 3.58

Global control of dimorphism and virulence in fungi. Science (2006) 3.50

On the complexity of self. Nature (1991) 3.43

An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A (1999) 3.15

Conjugative Transfer by the Virulence System of Agrobacterium tumefaciens. Science (1992) 3.07

Tracking epitope-specific T cells. Nat Protoc (2009) 2.96

Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest (2011) 2.66

Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity (1997) 2.46

Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol (2003) 2.03

CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells. J Exp Med (2006) 1.97

Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation. J Immunol (2000) 1.92

Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency. Immunity (2000) 1.83

Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells. Proc Natl Acad Sci U S A (2007) 1.71

Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis. J Exp Med (1999) 1.67

Advances in combating fungal diseases: vaccines on the threshold. Nat Rev Microbiol (2006) 1.58

Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. J Exp Med (2003) 1.58

T cell responses to Listeria monocytogenes. Curr Opin Microbiol (2004) 1.47

CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A (2006) 1.46

Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection. J Immunol (2009) 1.39

Improvement of the gene splicing overlap (SOE) method. Biotechniques (1995) 1.32

Agrobacterium tumefaciens integrates transfer DNA into single chromosomal sites of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast. Eukaryot Cell (2002) 1.29

Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance. J Clin Invest (2000) 1.27

Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol (2002) 1.22

Electroporation of Agrobacterium tumefaciens. Methods Mol Biol (1995) 1.21

Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes. Immunity (2012) 1.17

Cutting edge: regulation of CD8+ T cell effector population size. J Immunol (2004) 1.09

Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice. J Autoimmun (1995) 1.05

A TCR transgenic mouse reactive with multiple systemic dimorphic fungi. J Immunol (2011) 1.03

IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. J Immunol (2005) 0.97

Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis. J Immunol (2006) 0.92

Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis. J Biol Chem (2005) 0.90

Indirect regulation of CD4 T-cell responses by tumor necrosis factor receptors in an acute viral infection. J Virol (2007) 0.89

Investigation of anti-WI-1 adhesin antibody-mediated protection in experimental pulmonary blastomycosis. J Infect Dis (2000) 0.86

Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ T cells. Immunology (2002) 0.83

Articles by these authors

A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med (2011) 8.26

Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J Virol (2005) 4.72

Global control of dimorphism and virulence in fungi. Science (2006) 3.50

Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response. J Virol (2004) 2.71

Orthodontic speciality training in the UK. J Orthod (2002) 2.67

Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest (2011) 2.66

In the land of no evidence, is the salesman king? Am J Orthod Dentofacial Orthop (2010) 2.64

The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci U S A (2004) 2.39

Pause on avian flu transmission research. Science (2012) 2.24

Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization. Ann Surg Oncol (2003) 2.06

Pathogenesis of astrovirus infection. Viral Immunol (2005) 2.01

Phase mismatch-free nonlinear propagation in optical zero-index materials. Science (2013) 1.90

Astrovirus infections in humans and animals - molecular biology, genetic diversity, and interspecies transmissions. Infect Genet Evol (2011) 1.87

Edge nonlinear optics on a MoS₂ atomic monolayer. Science (2014) 1.83

Homozygosity mapping and whole-exome sequencing to detect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albinism and neutropenia. J Invest Dermatol (2011) 1.82

Use of nitisinone in patients with alkaptonuria. Metabolism (2005) 1.70

Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin. J Virol (2011) 1.69

Advances in combating fungal diseases: vaccines on the threshold. Nat Rev Microbiol (2006) 1.58

Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. J Exp Med (2003) 1.58

Unexplained nephrotic-range proteinuria in a 38-year-old man: a case of "no change disease". Am J Kidney Dis (2004) 1.54

Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. J Virol (2006) 1.54

Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome. N Engl J Med (2014) 1.53

Relationship of aortic valve calcification with coronary artery calcium severity: the Multi-Ethnic Study of Atherosclerosis (MESA). J Cardiovasc Comput Tomogr (2009) 1.52

Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. Nat Genet (2011) 1.48

Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication. J Virol (2005) 1.47

Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis. PLoS Pathog (2010) 1.44

Avian astroviruses. Avian Pathol (2002) 1.43

Ethnic differences between extra-coronary measures on cardiac computed tomography: multi-ethnic study of atherosclerosis (MESA). Atherosclerosis (2007) 1.38

Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe (2012) 1.35

Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages. J Immunol (2003) 1.34

Agrobacterium tumefaciens integrates transfer DNA into single chromosomal sites of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast. Eukaryot Cell (2002) 1.29

T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity (2015) 1.29

MOMENT--Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Trials (2013) 1.28

Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol (2002) 1.22

Astrovirus increases epithelial barrier permeability independently of viral replication. J Virol (2007) 1.18

Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes. Immunity (2012) 1.17

Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus. Obesity (Silver Spring) (2013) 1.17

Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection. J Immunol (2004) 1.16

Linking fungal morphogenesis with virulence. Cell Microbiol (2002) 1.15

Astrovirus induces diarrhea in the absence of inflammation and cell death. J Virol (2003) 1.15

Alveolar macrophage dysregulation in Hermansky-Pudlak syndrome type 1. Am J Respir Crit Care Med (2009) 1.15

Fungal adaptation to the mammalian host: it is a new world, after all. Curr Opin Microbiol (2008) 1.15

Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi. Cell Host Microbe (2010) 1.13

GLP-1 response to a mixed meal: what happens 10 years after Roux-en-Y gastric bypass (RYGB)? Obes Surg (2012) 1.13

Impaired wound healing predisposes obese mice to severe influenza virus infection. J Infect Dis (2011) 1.12

Mutation spectrum of homogentisic acid oxidase (HGD) in alkaptonuria. Hum Mutat (2009) 1.11

Inflammation and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis (2008) 1.11

Seroprevalence of seasonal and pandemic influenza A viruses in domestic cats. Arch Virol (2010) 1.09

Barriers and facilitators of hepatitis C screening among people who inject drugs: a multi-city, mixed-methods study. Harm Reduct J (2014) 1.09

Transmission studies resume for avian flu. Science (2013) 1.07

A TCR transgenic mouse reactive with multiple systemic dimorphic fungi. J Immunol (2011) 1.03

Interactome-wide prediction of short, disordered protein interaction motifs in humans. Mol Biosyst (2011) 1.03

Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17). Infect Immun (2011) 1.03

The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunogenic structure. J Virol (2010) 1.03

Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation. Mycopathologia (2002) 1.02

BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms. J Immunol (2002) 1.01

Symmetry breaking and optical negative index of closed nanorings. Nat Commun (2012) 1.01

Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog (2012) 1.01

Prevalence of obesity in International Special Olympic athletes as determined by body mass index. J Am Diet Assoc (2003) 0.99

A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem (2011) 0.98

A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection. J Infect Dis (2012) 0.98

IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. J Immunol (2005) 0.97

An influenza A/H1N1/2009 hemagglutinin vaccine produced in Escherichia coli. PLoS One (2010) 0.97

Review on the impact of pregnancy and obesity on influenza virus infection. Influenza Other Respir Viruses (2012) 0.97

Crystal structure of the avian astrovirus capsid spike. J Virol (2013) 0.96

Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. Environ Microbiol Rep (2009) 0.95

Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia. J Infect Dis (2003) 0.95

Genetic diversity in Blastomyces dermatitidis: implications for PCR detection in clinical and environmental samples. Med Mycol (2010) 0.95

SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog (2010) 0.94

The hemagglutinin protein of highly pathogenic H5N1 influenza viruses overcomes an early block in the replication cycle to promote productive replication in macrophages. J Virol (2012) 0.94

Diet-induced obese mice exhibit altered heterologous immunity during a secondary 2009 pandemic H1N1 infection. J Immunol (2013) 0.94

Seroprevalence of antibodies to influenza A/H1N1/2009 among transmission risk groups after the second wave in Mexico, by a virus-free ELISA method. Int J Infect Dis (2011) 0.94

Specific recognition of influenza A/H1N1/2009 antibodies in human serum: a simple virus-free ELISA method. PLoS One (2010) 0.94

Childhood posttraumatic stress disorder and efforts to cope after Hurricane Floyd. Behav Med (2002) 0.94

Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One (2012) 0.94

Development of a highly sensitive and specific blastomycosis antibody enzyme immunoassay using Blastomyces dermatitidis surface protein BAD-1. Clin Vaccine Immunol (2013) 0.93

Do attending physicians, nurses, residents, and medical students agree on what constitutes medical student abuse? Acad Med (2005) 0.93

Immunotherapy for fungal infections. Clin Infect Dis (2006) 0.93

Comparison of the self-administered and interviewer-administered modes of the child-OIDP. Health Qual Life Outcomes (2008) 0.93

Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis. J Immunol (2006) 0.92

Genomic analysis of closely related astroviruses. J Virol (2008) 0.92

A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS One (2011) 0.91

Viral gastroenteritis in children in Colorado 2006-2009. J Med Virol (2015) 0.91

Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy. Am J Reprod Immunol (2013) 0.90

Neoadjuvant radiotherapy for rectal cancer: adherence to evidence-based guidelines in clinical practice. World J Surg (2013) 0.90

Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis. J Biol Chem (2005) 0.90

Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity. Med Mycol (2005) 0.90

Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J Immunol (2012) 0.89

V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis. Infect Immun (2006) 0.89

Influenza virus infection in nonhuman primates. Emerg Infect Dis (2012) 0.88