PubRank

Lars M Ittner

Author PubWeight™ 62.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 2008 3.19
2 Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 2005 3.10
3 Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A 2009 2.04
4 Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell 2008 1.67
5 Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 2005 1.50
6 Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One 2011 1.45
7 Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. J Cell Biol 2005 1.44
8 Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS One 2010 1.37
9 Primary support cultures of hippocampal and substantia nigra neurons. Nat Protoc 2009 1.33
10 Design of custom-shaped vascularized tissues using microtissue spheroids as minimal building units. Tissue Eng 2006 1.29
11 Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A 2010 1.24
12 Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 2009 1.23
13 Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Dev Biol 2006 1.21
14 Divergent phosphorylation pattern of tau in P301L tau transgenic mice. Eur J Neurosci 2008 1.21
15 Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? J Neurochem 2006 1.17
16 A decade of tau transgenic animal models and beyond. Brain Pathol 2007 1.13
17 Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 2010 1.08
18 MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's disease. Exp Neurol 2011 1.08
19 Tau-targeted treatment strategies in Alzheimer's disease. Br J Pharmacol 2012 1.03
20 DiGeorge syndrome and pharyngeal apparatus development. Bioessays 2006 1.02
21 Lessons from tau-deficient mice. Int J Alzheimers Dis 2012 1.01
22 Animal models reveal role for tau phosphorylation in human disease. Biochim Biophys Acta 2009 1.01
23 The translocator protein (18 kDa): central nervous system disease and drug design. J Med Chem 2009 0.99
24 Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PLoS One 2012 0.97
25 Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats. Tissue Eng 2006 0.95
26 Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics 2006 0.95
27 Brief update on different roles of tau in neurodegeneration. IUBMB Life 2011 0.94
28 Modes of Aβ toxicity in Alzheimer's disease. Cell Mol Life Sci 2011 0.94
29 Tau aggregation and its interplay with amyloid-β. Acta Neuropathol 2014 0.93
30 Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Lett 2008 0.93
31 Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochem Biophys Res Commun 2009 0.90
32 Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. J Cereb Blood Flow Metab 2013 0.89
33 Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna) 2009 0.89
34 Slow excitotoxicity in Alzheimer's disease. J Alzheimers Dis 2013 0.89
35 Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods? J Alzheimers Dis 2008 0.88
36 Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochem Biophys Res Commun 2006 0.87
37 Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons. PLoS One 2011 0.87
38 Alzheimer's disease selective vulnerability and modeling in transgenic mice. J Alzheimers Dis 2009 0.87
39 Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem 2014 0.86
40 Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy? Med J Aust 2006 0.86
41 Self-assembly of sensory neurons into ganglia-like microtissues. J Biotechnol 2005 0.85
42 An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatr Dis Treat 2008 0.85
43 The translocator protein as a drug target in Alzheimer's disease. Expert Rev Neurother 2014 0.83
44 Dissecting toxicity of tau and beta-amyloid. Neurodegener Dis 2010 0.82
45 Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor. J Biol Chem 2004 0.82
46 Inducible, tightly regulated and non-leaky neuronal gene expression in mice. Transgenic Res 2013 0.80
47 Interaction of receptor-activity-modifying protein1 with tubulin. Biochim Biophys Acta 2007 0.80
48 Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mech Dev 2006 0.79
49 Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. Int J Dev Neurosci 2006 0.79
50 ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. J Neural Transm (Vienna) 2013 0.79
51 Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid 2010 0.79
52 The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo. Diabetologia 2014 0.79
53 ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. J Biomed Biotechnol 2011 0.78
54 Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One 2011 0.78
55 Alzheimer's disease models and functional genomics-How many needles are there in the haystack? Front Physiol 2012 0.77
56 Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegener Dis 2008 0.76
57 Tau protein: function and pathology. Int J Alzheimers Dis 2012 0.76
58 Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity. Am J Physiol Heart Circ Physiol 2007 0.76
59 Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest 2017 0.75